Diabetes-treating pharmaceutical compositions and its preparing method and uses

A technology of composition and diabetes, which is applied in the direction of drug combination, medical formula, drug delivery, etc., can solve the problems of different content results, low yield, unreported yield, etc., and achieve stable quality, obvious drug effect, and low cost Effect

Inactive Publication Date: 2006-10-04
SICHUAN INST OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biggest disadvantage of this method is: because the suspension is very thick, the resin will not fully absorb the saponin in it, which will result in a very low yield, and the process is quite cumbersome, so it is not suitable for large-scale industrial production (only feasible in the laboratory) , the method does not report the yield
That is to say, different reference substances have different measured content results. If the reference substance is not used, the purpose of quality control cannot be effectively achieved.

Method used

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  • Diabetes-treating pharmaceutical compositions and its preparing method and uses
  • Diabetes-treating pharmaceutical compositions and its preparing method and uses
  • Diabetes-treating pharmaceutical compositions and its preparing method and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1 Preparation of raw materials of the present invention

[0034](1) Crushing the crude drug into a coarse powder and passing through a 20-mesh sieve, placing it in an extraction tank, adding 2.5 times the amount of 80% ethanol (W / W) and heating under reflux for extraction for 2 hours. Collect the extract. Then add ethanol to the dregs and heat and reflux to extract twice, add 80% ethanol of 1.5 times the amount (W / W) each time, extract for 1.5 hours, combine three extractions, filter, and recover ethanol under reduced pressure at 60°C until there is no alcohol smell , to obtain a specific gravity of 1.2g / ml (thermal measurement) syrupy substance (brown yellow extract), its yield is 20 ~ 24% (W / W) of the charging amount. Dissolve the extract in 30 times the amount (W / W) of normal water, stir fully to make it dissolve completely. Filter through gauze, pass the filtrate through the treated WLD type macroporous adsorption resin tank (resin amount: crude drug am...

Embodiment 2

[0037] Embodiment 2 Pharmaceutical capsules of the present invention

[0038] 1, raw material: about 350g of fenugreek total saponins (prepared in embodiment 1), make 1000 pharmaceutical capsules of the present invention;

[0039] 2. Preparation: Grind total fenugreek saponins through a 60-mesh sieve, and fill No. 1 capsule shells manually or with a capsule machine under the condition of relative humidity below 68%, and control the contents to about 0.35g per capsule to prepare 1000 capsules.

[0040] The capsule can cover the bitter taste of the total fenugreek saponins; it has high drug availability, quick dispersion and good absorption in the gastrointestinal tract; and improves the stability of the drug.

[0041] 3, the preparation of pharmaceutical capsule of the present invention

[0042] Total fenugreek saponins 35kg, crushed and passed through a 60-mesh sieve, and mixed evenly. Get fine powder to measure total saponin content and trigonelside B content and water cont...

Embodiment 3

[0043] Embodiment 3 Identification of total fenugreek saponins in pharmaceutical capsules of the present invention

[0044] (1) Get about 1 mg of the extract prepared in Example 1, put it in a 10ml volumetric flask, add an appropriate amount of perchloric acid, dissolve and dilute to the mark, shake up, and within 30 minutes, according to the spectrophotometric method (Pharmacopoeia of the People's Republic of China 2000 Version one appendix VB) measured at 405 ± 2nm wavelength at the maximum absorption.

[0045] (2) Get 10 mg of the extract prepared in Example 1, add 2 ml of methanol to dissolve, test according to thin-layer chromatography (Appendix VIB of the Pharmacopoeia of the People's Republic of China 2000 Edition), draw 10 μl of the above solution, and spot on carboxymethyl cellulose On the silica gel H thin-layer board with sodium as the adhesive, use chloroform-methanol-acetic acid-water (volume ratio 25:12:2:2) as the developer, develop, take out, dry in the air, an...

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Abstract

The invention discloses a pharmaceutical composition for treating diabetes, which comprises trigonella foenum graecum saponin as the active portion, and pharmaceutically acceptable adjuvant or supplementary constituents, wherein the trigonella foenum graecum saponin is the extract of Trigonella foenum-graecum L., the content of the trigonella foenum graecum saponin is greater than 65% calculated by weight percent of trigonella foenum graecum saponin B. The effective ingredients of trigonella foenum graecum saponin A, B, C and D are determined in the specification.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating diabetes, in particular to a composition prepared from fenugreek as a raw material and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Diabetes mellitus (diabetes mellitus.) is a group of clinical syndromes caused by the interaction of genetic and environmental factors. Absolute or relative insufficiency of insulin secretion and decreased sensitivity of target tissue cells to islets lead to a series of disturbances in sugar, protein, fat, water and electrolytes. Clinically, hyperglycemia is the main sign, and prolonged illness can cause damage to multiple systems. Acute metabolic disorders such as ketoacidosis can occur in severe illness or stress. Severe complications such as coronary heart disease, ischemic or hemorrhagic cerebrovascular disease, blindness, and gangrene of the extremities were significantly higher in diabetics than in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/48A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P3/10
Inventor 徐学民杨红黄卫平齐尚斌李利民王笳袁崇均陈帅舒光明
Owner SICHUAN INST OF CHINESE MATERIA MEDICA
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