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Preparation method of degradable polymer material for stent in shape memory pipe cavity

A technology of polymer materials and memory tubes, applied in medical science, prostheses, etc., to achieve good biocompatibility and good shape memory

Inactive Publication Date: 2007-02-14
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, with lactide (LA), glycolide (GL), caprolactone (CL) copolymer or homopolymer and linear polyester (LPE) as raw materials, diisocyanate (DI) as the Preparation of biodegradable shape memory polymers (BSMPs) by bulk melt polymerization and applying them to endoluminal stents to treat various stenotic diseases has not yet been reported.

Method used

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  • Preparation method of degradable polymer material for stent in shape memory pipe cavity
  • Preparation method of degradable polymer material for stent in shape memory pipe cavity
  • Preparation method of degradable polymer material for stent in shape memory pipe cavity

Examples

Experimental program
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Embodiment 1

[0028] L-lactide (LLA), glycolide (GL) refined by ethanol recrystallization method, ethylene glycol, stannous octoate as raw materials, L-lactide (LLA), glycolide (GL) Molar ratio is 1: 6, and the ratio of ethylene glycol and L-lactide (LLA) and glycolide (GL) molar weight sum is 1: 20, add catalyst stannous octoate (0.05wt%, with LLA and GL total mass) at 140°C and N 2 Under protection, the pressure was reduced to 50 Pa, and the melt polymerization was carried out for 12 hours. After the reaction, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for future use; Polyester polybutylene succinate (PBS), hexamethylene diisocyanate (HDI) as raw materials, the molar ratio of PLGA and polybutylene succinate (PBS) is 1:3, hexamethylene The molar ratio of HDI to PLGA and PBS is 1:2, at 150°C and N 2 Under protection, the pressure was reduced to 50 Pa, and the melting rea...

Embodiment 2

[0031] D, L-lactide (DLLA), glycolide (GL), 1,3-propanediol and stannous chloride refined by ethanol recrystallization method are used as raw materials, D, L-lactide (DLLA), The molar ratio of glycolide (GL) is 1:1, the ratio of ethylene glycol to D, L-lactide (DLLA) and glycolide (GL) molar weight sum is 1:25, add catalyst chlorinated Tin (0.1wt%, based on the total mass of DLLA and GL) at 160 ° C and N 2 Under protection, the pressure was reduced to 65 Pa, and the melt polymerization was carried out for 18 hours. After the reaction, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for future use; Polyester polybutylene adipate (PBA), hexamethylene diisocyanate (HDI) as raw material, the molar ratio of PLGA, polybutylene adipate (PBA) is 1:1, hexamethylene The molar ratio of HDI to PLGA and PBA is 1:1, at 160°C and N 2 Under protection, the pressure was reduced ...

Embodiment 3

[0034] D, L-lactide (DLLA), glycolide (GL), 1,4-butanediol, stannous octoate refined by ethanol recrystallization method as raw materials, D, L-lactide (DLLA) , The molar ratio of glycolide (GL) is 6: 1, the ratio of ethylene glycol and D, L-lactide (DLLA) and glycolide (GL) molar weight sum is 1: 30, add catalyst octanoic acid sulfide Tin (0.1wt%, based on the total mass of DLLA and GL) at 180 ° C and N 2 Under protection, the pressure was reduced to 70 Pa, and the melt polymerization was carried out for 20 hours. After the reaction, add tetrahydrofuran to dissolve, then add methanol to precipitate and purify the product, and dry it in vacuum to obtain a white powdery hydroxyl-terminated PLGA for future use; Polyester adipate (PHA), lysine diisocyanate (LDI) as raw material, PLGA, polyhexamethylene adipate (PHA) molar ratio is 3:1, lysine diisocyanate (LDI) The molar ratio of isocyanate (LDI) to PLGA and PHA is 2:1, at 180°C and N 2 Under protection, the pressure was reduc...

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Abstract

The present invention belongs to the field of polymer technology, and is especially preparation process of degradable polymer for rack inside shape memory tube. Lactide, glycolide or caprolactone, biodegradable polyester and diisocyanate as materials are first bulk melt polymerized to prepare the degradable polymer with thermal deformation transforming temperature (Ttrns) of about 37 deg.c. The obtained material is processed at temperature over melting temperature (Tm) so as to shape into spiral rack, applied with stress at temperature higher than Ttrans to form shape easily operational handling and frozen to eliminate stress into the product. The rack inside shape memory tube has excellent biocompatibility, can provide temporary support on the stenotic lumen and is degradable without need of post-operational taking out. In addition, the rack may be also used as medicine carrier.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a preparation method of a biodegradable shape-memory endoluminal stent (Biodegradable Shape-Memory Endoluminal Stent, BSMES) used for the treatment of lumen stenosis diseases. Background technique [0002] Lumen stenosis is a common clinical disease, and endoluminal stent (ES) implantation is currently one of the most rapid and effective methods for the treatment of luminal stenosis. Leakage around the ES caused by small fissures is a common complication. The shape-memory alloys (SMAs) stents developed in recent years have effectively alleviated this problem. There are still certain limitations in its application due to the permanence of the drug, the limitation of the attached drug, restenosis, and the formation of aneurysm or perforation of the vessel wall due to medial atrophy caused by long-term compression. Considering the potential complications of me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G63/91C08G63/80C08G63/08C08G63/18A61L27/18
Inventor 任杰赵鹏任天斌顾书英
Owner TONGJI UNIV
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