Synthesis process of polyene taxol

A technology of docetaxel and its synthetic method, which is applied in the direction of organic chemistry, can solve the problems of reduced yield, high product cost, difficult separation, etc., and achieve the effect of less impurities, low cost and simple synthesis
CN1931849AActive Publication Date: 2007-03-21SHANGHAI JINHE BIO TECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI JINHE BIO TECH
Publication Date
2007-03-21

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Abstract

The present invention provides synthesis of polyene taxol, and the polyene taxol synthesizing path consists of three steps, including protection, condensation and hydrolysis, mainly. The material 10-deacetyl Baccatin III first has its 7th and 10th positions hydroxyl groups protected, then optical side chain introduced to its 13th position to obtain intermediate, and finally hydrolyzed to obtain the target product polyene taxol. The preparation process of the present invention has less steps, no isomer impurity, less side reactions, high utilization of material 10-deacetyl Baccatin III, high yield, low cost and other advantages. The product is for treating tumor clinically.
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Description

technical field

[0001] The present invention relates to the synthesis method of drug docetaxel for treating cancer. Background technique

[0002] Paclitaxel is a natural product with a complex structure extracted from the bark of perennial yew, and Docetaxel is a semi-synthetic derivative of paclitaxel, which is a taxol derivative synthesized during the structural modification of natural paclitaxel. Anti-tumor drugs that promote microtubule polymerization in cancer cells are currently one of the most widely used and most important anti-tumor drugs in clinical practice. Docetaxel, also known as docetaxel, docetaxel (English name transliteration), chemical name: [2aR-[2aα, 4β, 4aβ, 6β, 9α, (αR * , βS * ), 11α, 12α, 12aα, 12bα]]-β-[[(1,1-dimethylethoxyl)carbonyl]amino]-α-hydroxybenzonepropanoic-acid (12b-acetyloxy-12-benzoyloxy)-2a, 3, 4, 4a , 5, 6, 9, 10, 12, 12a, 12b-dodecahydro-4, 6, 11-trihydroxy-4a, 8, 13, 13-tetramethyl-5-oxo-7, 11-methano-1H-cyclodcca[ 3,4]benz[1,2-b...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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