Oral preparation containing gentamicin and its making method

A technology of gentamicin and preparation, applied in the field of therapeutic drugs and preparation thereof, can solve the problems of slow absorption, low blood drug concentration, affecting effective antibacterial efficacy and the like, and achieves the effect of eliminating the time limit of absorption and distribution and having fast onset of effect.

Inactive Publication Date: 2007-04-04
刘凤鸣
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the inconvenient use of injections and the tendency to cause local pain reactions when administered
Oral absorption of tablets, etc. is slow, and the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood drug concentration of the drug in the lesion is lower, and the time to reach the effective blood drug concentration in the lesion is also longer, affecting Its effective antibacterial potency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1-gentamicin candy

[0054] Prescription: 125g of gentamicin sulfate, 853g of sucrose, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, 2g of carbomer 934P, 1000 tablets.

[0055] Method: Prepare a mixture of 125g of gentamicin sulfate, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind it, and pass it through a 20-mesh sieve. Take 853 grams of sucrose, heat to 140°C to melt, cool to 85°C, add the sieved mixture, stir rapidly for 10 minutes, put it on a product forming machine and extrude, each lozenge weighs 1 gram. Then measure the disintegration time limit of gentamicin sulfate candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0056] Results: The disintegration time limit is 8-12 minutes, and the dissolution rate when completely disintegrated is 95%-99%.

Embodiment 2

[0057] Embodiment 2-low sugar gentamicin candy (1)

[0058] Prescription: gentamicin sulfate 125g, sucrose 203g, fructooligosaccharide 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, carbomer 934P 2g, preparation amount 1000 piece.

[0059] Method: Prepare a mixture of 125g of gentamicin sulfate, 10g of citric acid, 0.1g of food coloring-40, 10g of mannitol, and 2g of carbomer 934P, grind it, and pass it through a 20-mesh sieve. Take 203g of sucrose, 300g of fructooligosaccharide, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, cool to 85°C, add 125g of sieved gentamicin sulfate, stir rapidly for 10 minutes, and place in The product is extruded on a forming machine, and each lozenge weighs 1 gram. Then measure the disintegration time limit of gentamicin sulfate candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0060] Results: The disintegration time limit is 6-10 minutes, and the d...

Embodiment 3

[0061] Embodiment 3-low sugar gentamicin buccal tablet (1)

[0062] Prescription: gentamicin sulfate 125g, gelatin 240g, glycerin 60g, water 60g, fructooligosaccharides 133g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-40 0.1g, mannitol 10g, stearic acid Magnesium 10g, Carbomer 934P 2g, the dosage is 1000 tablets.

[0063] Method: prepare 240g of gelatin, 60g of glycerin, and 60g of water, dry it, add 125g of gentamicin sulfate, 133g of fructooligosaccharide, 300g of xylitol, 50g of inulin, 10g of citric acid, and 0.1g of food coloring-40, Mannitol 10g, Carbomer 934P 2g mixture, ground, passed through a 20-mesh sieve, granulated with ethanol and water, dried at 60°C, then added with 10 grams of magnesium stearate, mixed evenly, placed on a tablet machine for extrusion molding, Each lozenge weighs 1 gram. Then measure the disintegration time limit of gentamicin sulfate buccal tablet in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[...

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PUM

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Abstract

An orally absorbed medicine in the form of buccal lozenge, sweets, or dripping pill dissolved by saliva features that it contains gentamycin. Its preparing process is also disclosed.

Description

[0001] [Technical field] The present invention relates to a kind of therapeutic medicine and its preparation method, especially the buccal preparation containing gentamicin and its preparation method. [Background technique] [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Among them, those caused by group A strept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K9/20A61K9/48A61K31/7036A61P31/04
Inventor 刘凤鸣
Owner 刘凤鸣
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