Medicinal composition, food or drink having effect of enhancing sympathetic nervous activity

a technology of sympathetic nervous activity and composition, applied in the field of medicinal composition, can solve the problems of affecting the function of the body, and affecting the effect of the body, so as to achieve the effect of enhancing sympathetic nervous activity, and not causing a rise in blood pressur

Inactive Publication Date: 2010-06-17
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0079]As discussed above in detail, the present invention provides a medicinal composition, a food or a drink for controlling autonomic nervous activity per se (in particular, enhancing the sympathetic nervous activity) that are the fundamental factors causative of a disease or condition relating to the autonomic nervous activity. In particular, it provides a medicinal composition, a food or a drink having an effect of enhancing the sympathetic nervous activity of the white adipose tissue and the brown adipose tissue without causing a rise in blood pressure. Further, it provides a medicinal composition, a food or a drink having an effect of promoting energy metabolism. Thus, it provides a medicinal composition, a food or a drink which is efficacious and highly safe in treating obesity and / or related complications with little side effect (no rise in blood pressure) and can be conveniently produced.

Problems solved by technology

On the other hand, obesity has become a serious health problem not only in developed countries but also in developing countries, so that antiobesity measures are required worldwide.
Although antiobesity drugs have been developed and used around the world under these circumstances, it is also known that these drugs exert side effects.
As a typical example thereof, sibutramine (Meridia manufactured by Knoll, etc.) has a possible risk of inducing an increase in heart rate or a rise in blood pressure, which makes it difficult to administer this drug to patients with symptoms frequently occurring in obese persons such as hypertension, cardiac angina, congestive heart failure or cerebral stroke.
It is reported that these drugs exert side effects too.
However, no specific action on the white adipose tissue and the brown adipose tissue has been verified so far.

Method used

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  • Medicinal composition, food or drink having effect of enhancing sympathetic nervous activity
  • Medicinal composition, food or drink having effect of enhancing sympathetic nervous activity
  • Medicinal composition, food or drink having effect of enhancing sympathetic nervous activity

Examples

Experimental program
Comparison scheme
Effect test

example 1

Preparation of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (Purification from Lactic Acid Bacterium Culture Supernatant)

[0092]As the lactic acid bacterium culture supernatant, use was made of a freeze-dried culture supernatant obtained by culturing Lactobacillus plantarum SAM 2446 strain (FERM ABP-10438) in MRS medium. A sterilized MRS medium was inoculated with Lactobacillus plantarum SAM 2446 strain (FERM ABP-10438) which was then statically cultured therein at 37° C. for 1 day. Next, the cells were removed by centrifugation to give a culture supernatant. By use of the culture supernatant thus obtained, a freeze dried product was prepared by a conventional method and employed as the starting material. First, the lactic acid bacterium culture supernatant was ultra-filtered using Ultrafiltration Membranes YM10 (manufactured by Millipore) to give a low molecular fraction passing through the membranes. Next, the obtained fraction was chromatographically fractionated through Deve...

example 2

Evaluation of the effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on Rat Kidney Sympathetic Nervous Activity, Blood Pressure and Stomach Vagal (Parasympathetic) Nervous Activity

[0093]In these experiments, use was made of male Mister rats weighing about 300 g which had been fed in a thermostatic chamber (24° C.) with a light-dark cycle of 12-hour intervals (under illumination from 8:00 to 20:00) for 1 week or longer. A single rat was employed for each nervous experiment. The animals were fed with a feed (Oriental Yeast, MF) and water ad libitum. The autonomic nervous activity were examined by fasting the rats for 3 hours on the day of the experiment and then subjecting to an abdominal surgery under urethane-anesthesia at the intermediate point of the light period. Then, the effects of the transduodenal administration of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one obtained in Example 1 on the kidney sympathetic nervous activity, stomach vagal (parasympathetic) nervo...

example 3

Evaluation of the Effects of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on Rat Interscapular Brown Adipose Tissue Sympathetic Nervous Activity and Epididymal White Adipose Tissue Sympathetic Nervous Activity

[0095]The procedure of Example 2 was followed and thus the effects of the transduodenal administration (10 μg) of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one obtained in Example 1 on the rat epididymal white adipose tissue sympathetic nervous activity and the interscapular brown adipose tissue sympathetic nervous activity were examined in accordance with the methods reported in the documents cited in Example 2. A single rat was employed for each nervous experiment.

[0096]As a result, both of the interscapular brown adipose tissue sympathetic nervous activity (FIG. 6) and the epididymal white adipose tissue sympathetic nervous activity (FIG. 7) were enhanced.

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Abstract

It is intended to provide a safe composition for preventing or treating obesity or related complications which has an autonomic nervous control effect, in particular, an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism. Thus, a medicinal composition, a food or a drink containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and having an autonomic nervous control effect and an effect of promoting energy metabolism is provided.

Description

TECHNICAL FIELD[0001]The present invention relates to a medicinal composition, a food or a drink which contains 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and has an autonomic nervous control effect. Further, it relates to the medicinal composition, food or drink as described above which has an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism and is to be used for treating a disease or condition relating to the autonomic nervous activity or energy metabolism, in particular, obesity and / or related complications.BACKGROUND ART[0002]To maintain the homeostasis, a living body has the autonomic nervous system, the endocrine system and the immune system. Among these systems, the autonomic nervous system is relatively free from the cerebral control and acts automatically without being consciously controlled, which is the origin of the name. It mainly controls visceral functions. The autonomic nervous system comprises the sympathetic nervo...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K35/74A61K31/35A61K35/66A23F5/02A23F5/04A23F5/24C12N1/14C12N15/09
CPCC12N1/14A23F5/02
Inventor BEPPU, YOSHINORITSURUOKA, NOBUOROGI, TOMOHIROKOMURA, HAJIMENAGAI, KATSUYA
Owner SUNTORY HLDG LTD
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