Rsv f protein compositions and methods for making same

a protein composition and protein technology, applied in the field of rsv f protein compositions and methods for making same, can solve the problems of purification, homogeneous, structure and refolding, and difficult to obtain immunogenic preparations
US20110305727A1Inactive Publication Date: 2011-12-15GLAXOSMITHKLINE BIOLOGICALS SA +1
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Patent Information

Authority / Receiving Office
US ยท United States
Current Assignee / Owner
GLAXOSMITHKLINE BIOLOGICALS SA
Publication Date
2011-12-15
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
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Description

RELATED APPLICATIONS

[0001] This application claims the benefit of U.S. Patent Application No. 61 / 225,805, filed on Jul. 15, 2009, and U.S. Patent Application No. 61 / 294,426, filed on Jan. 12, 2010. The entire teachings of the above applications are incorporated herein by reference.BACKGROUND OF THE INVENTION

[0002] Respiratory syncytial virus (RSV) is an enveloped non-segmented negative-strand RNA virus in the family Paramyxoviridae, genus Pneumovirus. It is the most common cause of bronchiolitis and pneumonia among children in their first year of life. RSV also causes repeated infections including severe lower respiratory tract disease, which may occur at any age, especially among the elderly or those with compromised cardiac, pulmonary, or immune systems.

[0003] To infect a host cell, paramyxoviruses such as RSV, like other enveloped viruses such as influenza virus and HIV, require fusion of the viral membrane with a host cell's membrane. For RSV the conserved fusion protein (RSV F) fu...

Claims

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