System and method for delivering protease inhibitors
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example 1
[0084]A preparation of TA in PLGA at 5 percent loading for sustained release was prepared having the ingredients listed in the Table 1 below:
TABLE 1(1)TA with an average particle diameter of 3.3 micron where the particlediameter does not exceed 13 micron(2)PLGA with an intrinsic viscosity of 0.44 dl / gm inhexafluoroisopropanol (hereinafter “HFIP”) at 25° C. and a glasstransition temperature of 37° C. to 44° C. as established bydifferential scanning calorimetry(3)Dichloromethane (“DCM”) where a suspension of TA in DCMmay be dried and run by thermogravimetric analysis (“TGA”) andx-ray powder diffraction (“XRPD”) to demonstrate that DCM hasnot altered the structure of TA(4)Polydimethylsiloxane (“PDMS”) with a viscosity of 350 cSt(5)Cyclomethicone, for example D-5 cyclic siloxane,decamethylcyclopentasiloxane, also known as Mirasil ® CM-5 fromBluestar Silicones
[0085]The formulation of Example 1 was prepared as follows:[0086]1. Make a 2.5 wt. percent solution of PLGA in DCM by dissolving 0...
example 2
[0094]A preparation of TA in PLGA at 30 percent loading for sustained release was prepared according to method set forth in Example 1 above with the following alterations.
[0095]The formulation of Example 2 was prepared as follows:[0096]1. Use a proportionately higher amount of TA, e.g. 0.166 g TA, to prepare a loading of 30 wt. percent TA in PLGA.[0097]2. Also, penta-cyclomethicone, the cyclic pentamer, may be replaced with a cyclic tetramer, D-4, for example from Bluestar Silicones.
example 3
[0098]The formulation of Example 2 (i.e. 30 wt. percent TA in TA / PLGA microspheres) was characterized as follows:[0099]1. Use an optical or a Scanning Electron Microscope (“SEM”) to characterize as shown in FIG. 1A or 1B. The average diameter of the TA / PLGA microsphere was observed to be approximate 40 micron.[0100]2. Use Confocal-Raman Spectroscopy to characterize the 30 wt. percent TA in TA / PLGA microspheres as shown in FIGS. 2A, 2B and 2C. As shown in FIGS. 2A, 2B and 2C, it was observed that TA was distributed towards the center of the PLGA microsphere, which was desirable for sustained release.
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