Method of treating delayed healing of a wound associated with diabetes

a diabetes and wound technology, applied in the field of wound treatment, can solve the problems of affecting the healing process of wounds, affecting the regeneration of injured tissue, and none of these therapies, however, are completely effective, so as to promote the healing of delayed wounds, prevent and/or reverse premature cellular senescence, and promote wound healing.
US20150352064A1Inactive Publication Date: 2015-12-10KUWAIT UNIV
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
KUWAIT UNIV
Publication Date
2015-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The method of treating delayed healing of a wound associated with diabetes includes administering to the wound a composition comprising an anti-senescence compound and a pharmaceutically acceptable carrier. The anti-senescence compound may be 18α-Glycyrrhetinic acid, a Caveolin-1 (Cav-1) inhibitory compound, or a Polymerase I Transcript Release Factor (PTRF-1) inhibitory compound. The anti-senescence compound may be effective in preventing and / or reversing premature cellular senescence. The anti-senescence compound may be effective in promoting healing of a wound, e.g., delayed or incompletely healed wound. The anti-senescence compound may be effective in promoting healing of a delayed healing wound or chronic wound of a diabetic patient, such as a diabetic ulcer or venous ulcer.
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Description

BACKGROUND OF THE INVENTION

[0001] 1. Field of the Invention

[0002] The present invention relates to the treatment of wounds, and particularly to a method of treating delayed healing of a wound associated with diabetes, and particularly premature cellular senescence induced by diabetes.

[0003] 2. Description of the Related Art

[0004] Diabetic ulcers, such as diabetic foot ulcers, are a major complication of diabetes mellitus. Diabetic foot ulcers, in particular, occur in 15% of all patients with diabetes and precede 84% of all lower leg amputations. Major increases in mortality among diabetic patients, observed over the past 20 years, is considered to be due to the development of macro- and micro-vascular complications, including failure of the wound healing process.

[0005] Wound healing is an innate mechanism of action that works reliably most of the time. A key feature of wound healing is stepwise repair of lost extracellular matrix (ECM), which forms the largest component of the dermal ski...

Claims

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