Devices, systems and methods for the production of humanized gut commensal microbiota

a technology of gut microbiota and production method, which is applied in the field of ex vivo production of gut microbiota, can solve the problems of obesity, other conditions, and difficulty in understanding the exact mechanism of microbial influence in disease pathogenesis
US20180030403A1Inactive Publication Date: 2018-02-01SUBHADRA BOBBAN
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Patent Information

Authority / Receiving Office
US Β· United States
Current Assignee / Owner
SUBHADRA BOBBAN
Publication Date
2018-02-01
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

One embodiment provides a commensal gut production platform for ex vivo production of human gut commensal microbiota. Another embodiment provides devices, systems and methods for ex vivo culturing of gut microflora in a system that mimics the human gut environment. The culturing of the commensal microbiota in the disclosed systems produces gut microbiota having defined characteristics and properties that can be exploited to treat various conditions in a subject.
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Description

FIELD OF THE INVENTION

[0001] The present invention generally relates to the ex vivo production of gut microbiota and more particularly in a humanized commensal form that can be used for a variety of purposes such as therapeutics, diagnostics, and a research tool.BACKGROUND OF THE INVENTION

[0002] The human microbiota is the aggregate of microorganisms that resides on the surface and in deep layers of skin, in the saliva and oral mucosa, in the conjunctiva, and in the gastrointestinal tracts, and the human microbiome refers to their genomes. The human body consisting of about 100 trillion cells and carries about ten times as many microorganisms in the intestines. It is estimated that these gut flora have around 100 times as many genes in aggregate as there are in the human genome. Indeed, by cell count, humans are 10% human and 90% bacterial flora. The microbiome is reckoned to have around 3 million functional genes compared to 23,000 genes in human beings. The far larger genome of the ...

Claims

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