Use of a magnetic material in removal of stones

a magnetic material and stone technology, applied in the field of use of magnetic materials in the removal of stones, can solve the problems of affecting the removal effect, and reducing the removal effect of urinary stones, so as to achieve the effect of safe and efficient removal of urinary stones

Inactive Publication Date: 2018-09-27
SHANGHAI CLINICAL ENGINE TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Benefits of technology

[0006]The present invention is aimed to solve the problem of residual stone debris and difficult removal thereof in the conventional soft / hard ureteroscopic lithotripsy. Therefore, a first object of the present invention is to provide a use of a magnetic material in removal of stones; a second object of the present invention is to provide a magnetic material capable of safely and efficiently removing urinary stones located in the kidney, ureter, etc., wherein the magnetic material is a magnetic nano-material; a third object of the present invention is to provide a method for preparing the magnetic material in different morphological structures, wherein the magnetic material is a magnetic nano-material; a fourth object of the present invention is to provide a use of the magnetic material in combination with a self-made magnetic probe rod system in a urinary stones surgery, wherein the magnetic material is a magnetic nano-material; a fifth object of the present invention is to provide a use of the magnetic material in manufacture of an article for removal of stones in urinary system, wherein the magnetic material is a magnetic nano-material.
[0077]Specifically, the stone-removal magnetic probe rod system comprises a handle, a flexible rod, a magnetic field source, a magnetically permeable material section, etc., in which the handle may be provided with an AC or DC power supply, a power switch, a DC battery compartment and an AC plug; the flexible rod is made of a polymer material including, for example, PU, TPU, PE, PVC, NYLON, PEBAX and silicone rubber and the modified materials of the above materials, the magnetic field source made of a permanent magnet or electromagnet can be embedded in the flexible rod, and optionally a high performance magnetically permeable material is connected to the magnetic field source to form the flexible probe rod with different configurations, for example, the permanent magnet is placed in the middle or back end of the flexible rod, and the magnetically permeable material is placed in the distal end of the flexible rod, so that such configuration is more conducive to the treatment of renal stones under ureteroscope to avoid the situation that the distal end of the flexible rod becomes rigid due to the rigid structure of the permanent magnet or the electromagnet, so that such magnetic probe rod can be successfully inserted into the working channel of ureteroscope, and inserted into upper, middle and lower kidney calices to carry out stone removal operation when driven by the ureteroscope.
[0079]The invention provides a novel preparation process for synthesizing hydrophilic, hydrophobic, thermosensitive and pH-sensitive as well as photosensitive magnetic nanoparticles, which has the advantages of simple preparation process, good repeatability and convenient application. By the hydrophobic interaction between the prepared hydrophobic nanoparticles and stones, the chemical bond interaction between hydrophilic nanoparticles and stones, and the polymerization of the photosensitive nanoparticles under illumination, the stones are surrounded; and the thermosensitive and pH-sensitive nanoparticles can surround stones through physically surrounding action in ureter; thereby, small stone remaining in body can be removed quickly without damage from the body under the action of an externally applied magnetic field, that is, the stone can be drawn and moved without injuring ureteral wall, and meanwhile the nanoparticles are placed conveniently without shift.

Problems solved by technology

However, the current soft / hard ureteroscopic lithotripsy also has some deficiencies: 1) upper ureteral stones and fragments of stones in ureter may be easily brought back to kidney by the infused water or the recoil force of lithotripsy tools; 2) there is lack of a fast, safe and effective method to take out residual debris of stones in ureteral lumen and kidney calices.
However, the amount of stone removed by the stone basket every time is limited, so that multiple feeds of ureteroscope are needed, while repeated injection of water and feeds of ureteroscope would increase the risk of residual debris drift; in addition, the stone basket cannot completely seal the ureteral lumen, and there are still a chance that stones escape from the net; moreover, the edges of stones in stone basket may be easily squeezed out from basket holes, and thus may easily scratch the ureter wall when the stones are dragged and removed, thereby causing complications in severe cases.
However, when a gel-containing magnetic reagent (mock) is added to an aqueous solution containing stones, the cationic polymer is dispersed substantially in the form of dissolving in a solvent rather than aggregates to the periphery of stones due to the principle of similar compatibility, which is not sufficient to magnetize stones and remove stones.
In summary, there is an urgent need for a material and method for removal of stone in urinary system that can collect stones, facilitate the stone taking, do not damage the ureteral wall when the stones are dragged, can be conveniently placed and are not easy to cause shift of stone.

Method used

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Examples

Experimental program
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Effect test

example 2

Hydrophobic Polystyrene Surface Modification

[0152](Modification on the Magnetic Nanoparticle Core (MnFe2O4) Obtained in Example 1)

[0153]MnFe2O4 nanoparticles with an average particle size of 9 nm were added to an aqueous solution / 3-chloropropionic acid solution with a concentration of 1.0 mol / L initiator, the solution was adjusted to pH of 4 with hydrochloric acid, and stirred overnight. The nanoparticles were collected with a magnet, washed with water for several times to remove excess 3-chloropropionic acid. 0.22 g of dried nanoparticles were added to 8 mL of polystyrene solution under continuous feeding of nitrogen gas, followed by the addition of 4 mL of an xylene solution of 0.3 mmol of CuCl and 1.1 mmol of 4,4′-dinonyl-2.2-dipyridine. The above mixture reacted at 130° C. for 24 h under continuous agitation. The nanoparticles were collected with a magnet and washed repeatedly with toluene to obtain polystyrene-coated magnetic iron oxide nanoparticles.

example 3

Hydrophilic Polyacrylic Acid Modification

[0154]1 g of Fe3O4 obtained in Example 1 (for example, 10 nm Fe3O4 obtained by co-precipitation method) and 5 ml of a silane coupling agent (methacryloxypropyltrimethoxysilane, KH570) were mixed with 50 ml of xylene in a reaction flask. Under nitrogen protection, the reaction was carried out under stirring at 80° C. for 3 hours. After the reaction, the mixture was centrifuged and washed with ethanol three times to remove the silane coupling agent adsorbed on the surface of the Fe3O4 and vacuum-dried for 12 hours. The above-mentioned silane coupling agent-activated Fe3O4, 40 mg of potassium persulfate and 30 ml of deionized water were added in a flask, reacted under nitrogen protection and stirring at 40 for 10 minutes. Then, 4 ml of acrylic acid was slowly dropped into the flask, and reacted under nitrogen protection and stirring at 40° C. for 1 hour. The nanoparticles were magnetically separated, washed three times with deionized water and f...

example 4

Photosensitive Functional Modification of Nanoparticles

[0155]1. Synthesis of Photosensitive Functional Monomer

[0156]The synthesis method of photosensitive monomer with photo-crosslinking characteristics comprised: 4-vinylbenzophenone (4 VBP) and styrene monomer were directly polymerized by atom transfer radical polymerization (ATRP) to obtain a photosensitive polystyrene-polyvinylbenzophenone copolymer (PS-PVBP), wherein the specific steps were as follows: in a dry Schlenk tube connected with a reflux condenser, Cu(I)Br (0.695 mg, 4.8 umol), 4 VBP (1.0 g, 4.8 mmol), styrene (2 u, 20 umol) and 4-vinylbenzophenone (1 μL, 4.8 umol) were added, and the mixture was degassed for three times by means of freeze-pump-thaw circulation. Methyl bromopropionate (5.35 μL, 48 umol) was added to the above mixture at −78° C. under condition of nitrogen with positive pressure, and the mixture was degassed again for three more times by means of freeze-pump-thaw circulation. Polymerization was carried ...

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Abstract

The invention relates to a method of a magnetic material in stone removal, nanoparticles, a preparation method thereof and a stone removing device. Wherein, the magnetic material constitutes a nanoparticle core and a surface modifier monomer is attached to the nanoparticle core by an initiator and / or a crosslinking agent to form a nanoparticle shell. The prepared nanoparticles can surround stones in ureter, thereby, small stones remaining in body can be removed quickly without damage from the body under action of external magnetic field, that is, the stone can be drawn and moved without injuring ureteral wall, and the nanoparticles are placed conveniently without shift.

Description

TECHNICAL FIELD[0001]The present invention relates to a use of a magnetic material in removal of stones, nano-particles, a method for preparing the same, includes a device comprising nano-particles for removal of stones.BACKGROUND ART[0002]Urinary calculi / stone (urolithiasis) have an incidence as high as 5% -10%, and can be found in any part of kidney, bladder, ureter and urethra, in which stones in kidney and ureter are common. It is found in clinical observation that calcium-containing stones are the most common types of urinary stones, that is, about 70% to 80% of all urinary stones. At present, there are only a few cases of calcium-containing stones which pathological causes have been clearly revealed, while the causes for most of calcium-containing stones are not yet clear. According to chemical composition, stones can be divided into four categories: calcium-containing stones, infection induced stones, uric acid stones and cystine stones. Calcium-containing stones can be divid...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61B34/00A61B17/22A61L31/02A61L31/04
CPCA61B34/73A61B17/22A61L31/022A61L31/04A61B2017/00526A61B2017/00876A61L31/02A61L31/14A61P13/04A61B17/52A61L31/10B22F1/102B22F1/07A61L2400/12B82Y5/00A61B17/00A61K33/26A61B1/00165A61B1/00195A61B1/051A61B17/225A61B2017/00477A61B2017/00734A61B2017/22082A61L31/048A61B2017/22087A61L31/028
Inventor SUN, YINGHAO
Owner SHANGHAI CLINICAL ENGINE TECH DEV CO LTD
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