3 results about "Dermodesis" patented technology

The present application belongs to the technical field of detection reagents, and particularly relates to a dermatophyte detection kit based on a recombinant LGBP-FITC fluorescent probe and application thereof. The present application obtains LGBP-Cys protein by performing C-terminal cysteine site-directed mutation on LGBP protein from Procambarus clarkii; then, the LGBP-Cys protein is directionally coupled with maleimide-activated FITC under mild neutral conditions, so that the problem of protein activity damage caused by traditional random coupling is solved; finally, the coupling product is placed in a composite stabilizing solution containing an anti-quenching agent, so that the stability of the probe and the detection signal-to-noise ratio are significantly improved. The kit is simple to operate, and detection can be completed within 15 minutes. The kit has high sensitivity, high specificity and visualization advantages for common clinical dermatophytes, and is suitable for rapid bedside diagnosis.

The application discloses a traditional Chinese medicine composition for treating skin tinea, which is made of the following components in parts by weight: 20-40 parts of Sophora flavescens, 10-20 parts of Stachys robusta, 10-20 parts of Kochia scoparia, 10-40 parts of Solpugid, 20-40 parts of Sphaeropsidipus, 20-40 parts of Phellodendron, 20-40 parts of Dictamnus dasycarpus, 20-40 parts of Cnidium monnieri, 10-20 parts of Melioidzine, 10-20 parts of Zanthoxylum bungeanum and 10-20 parts of Scophularia ningpoensis. In the traditional Chinese medicine composition, Sophora flavescens, Phellodendron and Dictamnus dasycarpus can clear heat and dry dampness, Stachys robusta, Kochia scoparia, Solpugid, Sphaeropsidipus, Cnidium monnieri and Scophularia ningpoensis have the effect of killing insects and stopping itching; in addition, Melioidzine can invigorate the spleen and dispel wind, and Zanthoxylum bungeanum can increase the transdermal effect of the composition, so that the whole composition can better play the treatment role of clearing heat and dry dampness, killing insects and stopping itching.

Compositions and methods for treatment of onychomycosis and dermatophytoma are presented. In particularly contemplated aspects, high treatment efficacy is achieved in an atraumatic manner. Moreover, due to the high retention of the antifungal agent in the treatment space and advancement of a newly formed healthy nail plate, onycholysis can be reduced or even entirely reversed, thereby preventing recurrence of infection. Still further, contemplated compositions and methods substantially avoid systemic exposure while achieving high local drug concentration in the treatment space.