55 results about "Dermodesis" patented technology

The invention discloses a polyrotaxane-structured NO donor material and a preparation method and application thereof. The polyrotaxane-structured NO donor material is an internal lock supramolecule formed by sleeving a dumbbell-shaped PEG-PPG-PEG linear molecule with a cationized beta-cyclodextrin molecule, wherein the beta-cyclodextrin molecule can freely slide on the PEG-PPG-PEG linear molecule.The internal lock supramolecule serving as an NO donor material can effectively inhibit growth and reproduction of bacteria and fungi, has a remarkable inhibiting effect on common pathogenic bacteria, dermatophytes, wound infection bacteria and the like, has functions of promoting wound healing, diminishing inflammation and the like, and can be applied to preparation of biomedical engineering materials.

The invention relates to primers and kit for fluorescent PCR detection of nine dermatophytes, and belongs to the technical field of in-vitro molecular detection of pathogenic microorganisms. The primers include an upstream primer with a nucleotide sequence which is shown in SEQ ID No: 1 and a downstream primer with a nucleotide sequence which is shown in SEQ ID No: 2, wherein the nine dermatophytes include Trichophyton rubrum, Trichophyton mentagrophyte, Trichophyton violaceum, Trichophyton schoenleinii, Epidermophyton floccosum, Trichophyta verruca, Microsporum canis and Microsporum gypsum. The detection is fast, sensitive, specific and repeatable through the primers, and the primers can be applied to early, non-invasive and accurate detection of clinical patients, so that assistance of clinical and effective antifungal therapy is achieved.

The invention belongs to the field of natural medicine and cosmetics, and provides application of Chinese torreya essential oil to preparation of anti-dermatophytes medicine, or application of Chinese torreya essential oil as efficiency ingredients in cosmetics for inhibiting the dermatophytes. In-vitro antibacterial activity study on the Chinese torreya essential oil shows that the Chinese torreya essential oil has better antibacterial activity on common pathogenic dermatophytes capable of causing tinea capitis, tinea corporis and little onychomycosis. The Chinese torreya essential oil is essential oil prepared from Chinese torreya aril by a distillation method, a cold squeezing method, a solvent extracting method or a carbon dioxide supercritical extraction method and the like. The Chinese torreya essential oil has the quality requirements that the Chinese torreya essential oil is colourless to yellowish Green liquid, and has the characteristic flavor of Chinese torreya fruit; the relative density (20 DEG C / 20 DEG C) is 0.850 to 0.860; the content sum of characteristic components of Alpha-pinene and limonene is greater than or equal to 30 percent. The invention discloses a new purpose of the Chinese torreya essential oil to prepare anti-dermatophytes medicine or cosmetics. In addition, an optimized preparation method of the Chinese torreya essential oil is provided by comparing the advantages and disadvantages of different extraction methods of the Chinese torreya essential oil.

The invention relates to methods assessing nucleic acids encoding a dermatophyte extracellular serine / threonine-rich protein (ESTRP gene) in identifying and preferably differentiating between dermatophytes. The invention relates further to corresponding detection kits, in addition to isolated probes and oligonucleotides.

The invention provides a medicine for treating skin itch dermatophytosis. The medicine is prepared from the following traditional Chinese medicinal materials in parts by weight: 1.5-2.0 parts of huechys, 1.5-2.0 parts of mylabris, 3.0-4.0 parts of brucea javanica kernel, 0.5-1.0 part of gamboge, and 300 parts of white vinegar. The medicine is simple in components for treating itching syndrome dermatophyte, low in price and good in curative effect, can be used for radically treating dermatophyte, is mainly used for treating psoriasis, tinea manuum, tinea pedis and the like, and solves the problems of complicated prescription, high cost, radical treatment unavailability and repeated attack and the like for current dermatophyte treatment.

The present invention provides an improved preparation based on the synergistic action of garlic extract and essential oil of M. spicata var. Ganga or cinnamon oil against dermatophytic fungus. More particularly, the present invention relates to the synergistic enhancement of activity of a combination by menthyl acetate or Geraniol. The invention also provides a method of preparation of the synergistic combination and the shelf life observed to be more than one year. The cream based preparation is a potent anti-dermatophytic as described and illustrated by in vitro and in vivo evaluations.

The invention discloses a compound clobetasol propionate nano-medicament of which the particle size is 1-100 nanometers. The medicament consists of the following components in percentage by weight: 10.0-50 percent of surfactant, 0-8 percent of cosurfactant, 0.5-20 percent of oil, 0.001-4.0 percent of amitraz, 0.001-4.0 percent of clobetasol propionate, 0.001-10 percent of terbinafine and the balance of distilled water, wherein the total percentage by weight of the components is 100 percent. The medicament has the effects of resisting bacteria, diminishing inflammation, relieving itching and pain, killing mites and treating fungal diseases, eczema and various types of dermatitis caused by fungi such as dermatophyte, microsporosis capitis, acrothesium floccosum, microzyme of monilia and chaff ringworm fungus, and the like. The medicament is a yellow or colorless clear transparent liquid and has the advantages of high stability, high wetting property, good transdermal effect, nontoxicity, non-irritation, high safety, easiness for preparing, low cost and convenience for popularizing.

Dermatophytes which belong to one of the three genera Epidermophyton, Trichophyton and Microsporum are the main cause of fungal infections of skin, hair and nails. Traditional diagnostic procedures consist of microscopy and culture, but due to the slow growth rate of dermatophytes typically two to four weeks are needed before a final diagnosis is obtained. The present invention is a rapid DNA extraction method extracting nucleic acids from fungi (e.g. dermatophytes and other pathogenic fungi) which can be performed from directly on hair, nail or skin specimens from humans, from naturally or experimentally infected animals or from cultured fungal colonies for the use in PCR amplification and detection assays. The present invention also includes specific primer sets for detection of any dermatophyte and for species specific detection of Trichophyton rubrum and Epidermophyton floccosum by PCR and a kit for diagnosing fungal infections.

The invention relates to the technical field of microbial antibiosis, and provides application of polyphyllin in preparation of a product for resisting a candida albicans fluconazole drug-resistant strain and a product for resisting dermatophyte. The polyphyllin has a definite inhibition effect on a candida albicans fluconazole drug-resistant strain, epidermophyton flocculent, microsporum gypsum and trichophyton rubrum, is steroidal saponin, and is greatly different from the currently common azole antifungal drugs such as ketoconazole, fluconazole, itraconazole and the like in structure. The mechanism of the polyphyllin for resisting a candida albicans fluconazole-resistant strain, epidermophyton flocculent, microsporum gypsum or trichophyton rubrum is different from that of azole antifungal drugs, and the polyphyllin is added into the antibacterial product, so that the common antifungal drug-resistant bacteria can be inhibited, the drug resistance and irritation of the preparation are reduced, and the safety of the preparation is improved.