Disclosed is a sealing cover, which is suitable for sealing an opening of a container, comprising an extrusion lid and a flexible sealing ring, wherein the container has an opening, the extrusion lid comprises an outer cover, an inner shield cover, a screw rod and a knob, the outer cover covers the opening, and the inner shield cover is arranged in the opening and is located under the outer cover; the screw rod movably penetrates the outer cover, the lower end of the screw rod is fixedly connected to the inner shield cover, and the upper end of the screw rod is connected in a threaded manner to the knob; and the flexible sealing ring is sheathed on the screw rod and is located between the outer cover and the inner shield cover, and when the knob is rotated, the screw rod drives the inner shield cover to move upwards and squeezes the flexible sealing ring to force the flexible sealing ring to be attached to an inner circumferential wall of the opening after expansion to form a seal. The sealing cover provided by the present invention can seal the opening of a container, and the sealing cover has a simple structure, is convenient to use, and has a good sealing effect.