The embodiment of the utility model provides a kind of applicator, smearing device and smearing set, it is related to medical instrument field.The applicator includes shell and pressing structure, the inside of shell is formed with container accommodating cavity, container accommodating cavity can accommodate at least two containers, shell is penetrated with pressing hole, pressing hole and container accommodating cavity are communicated, pressing structure includes the pressing piece and the press broken piece of connection, pressing piece and shell movably connect, pressing piece is used to drive press broken piece to pass through pressing hole and directly act on the surface of container under external force, so that press broken piece breaks container, the liquid of container flows out and reaches smearing cotton, to carry out subsequent smearing work.In use, pressing structure can directly act on the surface of container, can realize smaller force to break container, and it is more labor-saving to use.