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Allicin microcapsule and its preparation method

A technology of allicin and microcapsules, applied in the directions of microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of unsatisfactory allicin packaging effect, poor dispersibility and absorption, volatile allicin, etc. Effects of odor, broad applicability, good biocompatibility

Inactive Publication Date: 2008-02-13
OCEAN UNIV OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage of this technology is that the packaging effect of volatile, extremely unpleasant and unstable substances such as allicin is not ideal
However, allicin has a strong irritating and unpleasant smell, and is unstable when exposed to the air, and is easily oxidized and decomposed to lose efficacy
The traditional packaging methods of allicin are in the form of powder adsorption method and drop pill preparation. The disadvantages of powder adsorption are that allicin is volatile, unstable, and heavy in garlic taste; the disadvantages of drop pill preparation are large volume, poor dispersibility and absorption. good

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Pass the granular starch through a 60-mesh sieve with a moisture content of 0.3%, take 40 grams of it, add 41 grams of allicin, stir well, dissolve polymethyl methacrylate in ether solution, the concentration is 10%, take 100 ml of it and spray it on On the above dry product under agitation, dry at 50°C, configure shellac into a 12% aqueous solution, heat to 70°C to dissolve evenly, cool to room temperature, take 85 ml of the solution, and disperse the starch evenly in the solution under stirring, 60°C Airflow drying forms granular powder to obtain allicin microcapsule product with an allicin content of 50%.

Embodiment 2

[0022] Pass the water-soluble starch through a 150-mesh sieve, dry it to a moisture content of 1%, take 65 grams of it, add 20 grams of garlic oil, stir well, prepare the gum arabic into a 40% aqueous solution, heat it to 30°C, and take 100 ml of the solution , uniformly disperse the starch in the solution under stirring, and then blow it away with hot air at 100°C to form a dry granular powder; then dissolve the acetyl fiber in ethanol with a concentration of 10%, and spray it on the above dry product under stirring, 50 °C and dried, the allicin microcapsule product is obtained, and the allicin content is 14.2%.

Embodiment 3

[0024] Pass dextrin through a 200-mesh sieve with a water content of 12%, take 95 grams of it, add 120 grams of garlic juice, stir evenly, heat up to 82°C, keep warm for 1 hour, dissolve corn protein in acetone solution, concentration 4%, 50 Spray on the above-mentioned dry product under agitation, and dry at 50°C. The carboxymethyl chitosan derivative is configured into a 2% aqueous solution, heated to 30°C to dissolve evenly, cooled to room temperature, and 200 ml of the solution is taken, and the starch is dissolved under stirring. Uniformly dispersed in the solution, and then freeze-dried to form granular powder to obtain the allicin microcapsule product, the allicin content is 0.11%.

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Abstract

Disclosed is an allicin microcapsule and its preparation method, wherein garlicin and starch are used as the core, hydrosol is used as the inner layer membrane, the grease collosol is an outer layer membrane structure, the garlicin, starch, hydrosol and grease collosol accmounts to 0.1-50%, 10-90% and 0.5-10% of the total product weight. The preparing process consists of attaching the garlicin onto the starch carrier, coating a layer of hydrosol solution onto the granule surface, forming an inner layer hydrosol covering film through drying and dehydration, than coating a layer of grease collosol solution, drying and removing organic solvent to form the outer layer collosol covering film.

Description

technical field [0001] The invention relates to an allicin microcapsule and a preparation method thereof. Background technique [0002] Microcapsule technology is one of the key high-tech developments in the 21st century. It is a rapidly developing and widely used technology in the world today. The process of preparing microcapsules is called microencapsulation, which is to wrap solid, liquid or gas In a tiny capsule, the shape of the microcapsule can be spherical, kidney-shaped, grain-shaped, block-shaped, etc. The substances forming microcapsules are isolated from the external environment and can be protected from environmental influences, thereby maintaining stability, and under appropriate conditions, the encapsulated substances can be released. After entering the 1970s, the process of microcapsule technology has become increasingly mature, and the scope of application has gradually expanded. It has expanded from the initial drug coverage and carbonless copy paper to va...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/105A61K9/50A61P1/04A61P1/02A61P13/12A61P35/00A61P9/12A61P9/10
Inventor 陈西广于建刘成圣孟祥红于乐军贺君
Owner OCEAN UNIV OF CHINA
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