Compound spray for treating rhinitis and preparation method thereof

A technology for spray and rhinitis, applied in the field of traditional Chinese medicine preparations, can solve the problems of large loss of effective components in the water extraction process, dull market response, and difficulty in storing clothes, etc., and achieves good storage stability, enhanced immune function, and fine droplets.

Active Publication Date: 2010-01-13
GUANGXI JIAJIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because it is an ointment, it has many disadvantages in the dosage form, such as slow onset of action, difficulty in quantification, carrying easily polluted clothes and difficult storage, etc., all of which limit its use.
Therefore, the market response is flat, and currently only Guangzhou Hejigong Pharmaceutical Co., Ltd. produces
In addition, this variety also has many shortcomings in terms of technology and quality control: first, the Andrographis paniculata concentrate in the prescription is the water-extracted concentrate of Andrographis paniculata medicinal material, and according to literature reports, andrographolide and dehydroandrographolide, the effective antibacterial and anti-inflammatory components of Andrographis paniculata They are all insoluble in water. Obviously, the loss of active ingredients in the water extraction process is not advisable; secondly, the prescription of this variety contains adrenergic receptor agonist ephedrine hydrochloride and antihistamine diphenhydramine hydrochloride, which should be strictly controlled. However, the quality standard of this variety does not control the content of the two, resulting in poor product safety

Method used

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  • Compound spray for treating rhinitis and preparation method thereof
  • Compound spray for treating rhinitis and preparation method thereof
  • Compound spray for treating rhinitis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1 compound rhinitis spray

[0023] Concrete technological process schematic diagram refers to shown in 1, and preparation method is:

[0024] (1) Take by weighing 3000g Andrographis paniculata L. and cut into small sections less than 5cm, add 85% ethanol to reflux and extract twice, add 9 times of ethanol for the first time, add 8 times of ethanol for the second time, reflux for 1.5 hours each time, combine Medicinal solution, filtered, ethanol recovered from the filtrate, concentrated under reduced pressure to 2 times the amount of the crude drug, added activated carbon with 4% of the crude drug amount and refluxed for 30 minutes, filtered, the filter residue was washed with an appropriate amount of 50-65% ethanol, filtered, and the above filtrates were combined, Recover ethanol, concentrate under reduced pressure into a thick paste with a relative density of 1.15-1.25 (60°C), and set aside;

[0025] (2) Weigh 1000g goose not eating grass, add water and dec...

experiment example 1

[0027] Experimental Example 1 Extraction verification test of Andrographis paniculata

[0028] Experimental method: 100g of Andrographis paniculata, cut into sections, add 85% ethanol to reflux twice, add 9 times for the first time, add 8 times for the second time, reflux for 1.5 hours each time, combine the medicinal liquid, filter, weigh, and measure Andrographis paniculata Lactone and dehydroandrographolide content, calculate the total transfer rate, the results are shown in Table 1.

[0029] Table 1 The results of the verification test for the extraction of effective components from Andrographis paniculata

[0030]

[0031] The verification test results are basically consistent, the three tests RSD = 1.75%, indicating that the extraction method has good stability.

experiment example 2

[0032] Experimental example 2 Purification process verification experiment of the extract of Andrographis paniculata

[0033]Experimental method: Three batches of verification were carried out according to the process conditions. Each batch took 1 kg of Andrographis paniculata, cut into small pieces <5 cm, and added 85% ethanol to reflux for extraction twice, adding 9 times for the first time and 8 times for the second time, and refluxed each time Extract for 1.5 hours, combine the decoction, filter, recover the ethanol from the filtrate to 2 times the crude drug amount, add activated carbon with 4% crude drug amount and reflux for 30 minutes, filter while hot, wash the filter residue with an appropriate amount of dilute ethanol, filter, combine the filtrate, and recover Ethanol, measure the total amount of andrographolide and dehydroandrographolide in the liquid medicine, and calculate the transfer rate. The results are shown in Table 2:

[0034] Table 2 Andrographis panicul...

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Abstract

Disclosed is a compound mist for treating rhinitis and its preparation method, wherein each 1000ml of the water solution contains 300g of ethanol extract of green chiretta, 100g aqueous extract of centipede, 5g d-pesudoephedrine hydrochloride, 1.5g of diphenhydramine hydrochloride, 10ml of peppermint oil, 10ml of eucalyptus oil, 30g of polyvidon K3O, 40g of polysorbate-80, 5.7g of sodium chloride and 2g of potassium sorbate.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, especially a compound rhinitis spray for treating rhinitis, and also relates to a preparation method of the compound rhinitis spray. Background technique [0002] The nasal cavity is located at the forefront of the respiratory tract. It has the functions of humidifying, warming and filtering the inhaled air. It is the first line of defense of the respiratory system and one of the organs most susceptible to infection. When inflammation enters the human body, the lower respiratory tract and related The only way for the spread of adjacent organs. In recent years, due to reasons such as air pollution, global warming, sudden temperature changes, bacterial virus infection, exposure to allergens, and decreased body resistance, the incidence of various nasal inflammations is on the rise. According to statistics, the prevalence of various rhinitis is about 10% to 40% in the west, and accordin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61K36/61A61K9/12A61P11/02A61K31/138A61K31/137
Inventor 彭桂华黄轩清
Owner GUANGXI JIAJIN PHARMA
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