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Dripping pills of schefflera arboricola, and its preparing method

A technology of Aescinus chinensis and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of affecting the full effect of the medicine, low bioavailability, unstable quality, etc., and achieves benefits Labor protection and environmental protection, high bioavailability, good drug stability

Inactive Publication Date: 2007-07-25
陈茜
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the characteristics of conventional tablet preparation technology, such oral preparations have long disintegration time, poor absorption, slow onset of action, and low bioavailability, which affect the full play of drug efficacy.
At the same time, it is easy to split, change color, absorb moisture, etc. during storage, and the quality is unstable

Method used

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  • Dripping pills of schefflera arboricola, and its preparing method
  • Dripping pills of schefflera arboricola, and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Take 3000g of horse chestnut leaves, add water and decoct twice. The amount of water added is 8 times the amount for the first time and 6 times the amount for the second time. The decoction time is 3 hours for the first time and 2 hours for the second time. Combine the decoction, let it stand for 12 hours, filter, and concentrate the filtrate to an extract with a relative density of 1.12~1.22 (60℃). Add ethanol to make the alcohol content 60%. Stir evenly, let stand for 12 hours, and take the supernatant Recover ethanol and concentrate it to an extract with a relative density of 1.15~1.25 (60℃). Add ethanol to make the alcohol content 70%. Stir it evenly. Let it stand for 12 hours. Take the supernatant to recover the ethanol and concentrate it into the extract. The extract is vacuum dried to obtain an extract. Take the extract, crush, and pass through a 100-mesh sieve. The weight ratio is horse chestnut extract: polyethylene glycol 6000 =1:2 ratio, add it to the ...

Embodiment 2

[0017] Example 2: Take the extract of Example 1, pulverize, and pass through a 100-mesh sieve. According to the weight ratio, the ratio of horse chestnut extract: mixed matrix = 1:1.5 (the mixed matrix is ​​polyethylene glycol 6000 :Poloxamer according to the formula of 1:0.3), add it to the molten mixed matrix (82℃), stir evenly, drop into the simethicone coolant (3℃), separate the dripping pills, absorb and cool Agent, dry, ready.

Embodiment 3

[0018] Example 3: In this example, through the formulas of horse chestnut extract and different substrates, indicators such as roundness, pill weight difference, hardness, and dissolution time were investigated to determine the weight ratio of the extract to the single or mixed substrate.

[0019] Horse chestnut extract and different matrix formula test (extracts are 1 copies)

[0020] Note: 1. The coolant is dimethyl silicone oil or liquid paraffin, and the cooling temperature is 1~5℃; the temperature of the medicine material and dripper is 80~85℃; the dripping speed is 30~50 particles / min.

[0021] 2. The above results show that all the indexes of test No. 4-11 are good, that is, when the ratio of extract to substrate is 1:1 to 1:5, it can be dripped smoothly. However, considering the dosage and other factors, the preferred ratio is Test No. 4, 6, 8, and 10, that is, the ratio of extract to matrix is ​​1:1 to 1:2.

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PUM

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Abstract

A dripping pill of scandent schefflera for treating pain, rheumatalgia, neuralgia, stomach-ache, bone fracture, injury, etc is prepared from scandent schefflera root. Its preparing process is also disclosed.

Description

Technical field [0001] The invention belongs to the technical field of Chinese medicine pharmacy, and particularly relates to a horse chestnut dripping pill and a preparation process thereof. Background technique [0002] Horse chestnut is also known as Evergreen, five-clawed leaves. It is the root or stem and leaf of Schefflera arboricola Hagata, an Araliaceae plant, mainly produced in Yunnan. Horse chestnut has the effects of activating blood circulation and removing blood stasis, relieving pain and swelling, relaxing muscles and collaterals, and expelling wind and dampness. The leaves of horse chestnut are commonly used in the folks to smash and contract to treat fractures, pain, and traumatic bleeding. Modern pharmacological studies have confirmed that horse chestnut has strong analgesic, sedative, and anticonvulsant effects, and it also has a pain relief effect by significantly inhibiting smooth muscle contraction. It is suitable for the treatment of various pains, rheumatic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/25A61K9/20A61P25/00A61P19/00A61P7/04A61K125/00A61K127/00
Inventor 陈茜滕慧丽
Owner 陈茜
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