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Traditional Chinese medicine Ningxintong preparation for treating unstable angina in the coronary heart disease and preparation method thereof

A traditional Chinese medicine preparation and unstable technology, which is applied in the direction of medical formula, cardiovascular system diseases, medical preparations containing active ingredients, etc., can solve the problems of lack of dosage form reform, weak research and development of new traditional Chinese medicine, lack of scientific research design, etc.

Active Publication Date: 2010-07-28
NANJING HOSPITAL OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Another example: Some clinical research lacks reasonable scientific research design, such as lack of rigorous randomization, control, double-blind, small sample size, poor repeatability, and clinical efficacy needs to be further confirmed and improved; some clinical detection indicators are too simple
Another example: Some clinical treatments only stay in the dosage form of traditional Chinese medicine decoction, lack of necessary dosage form reform, and the research and development of new Chinese medicine is a relatively weak link

Method used

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  • Traditional Chinese medicine Ningxintong preparation for treating unstable angina in the coronary heart disease and preparation method thereof
  • Traditional Chinese medicine Ningxintong preparation for treating unstable angina in the coronary heart disease and preparation method thereof
  • Traditional Chinese medicine Ningxintong preparation for treating unstable angina in the coronary heart disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0042] Embodiment 2. Ningxintong preparation (capsule) is made of the crude drug of following weight ratio

[0043] [Prescription] Astragalus 15g Asarum 8g

[0044] Chuanxiong 15g Pueraria 10g

[0045] Holly hair 10g

[0046] [preparation method]

[0047] 1. Take 8 times the amount of Rhizoma Chuanxiong and Asarum in the prescription, add water, soak for 1.5 hours, refer to the "Chinese Pharmacopoeia" 2000 edition 1 appendix volatile oil determination method to extract volatile oil for 8 hours, release the oil layer after cooling to collect volatile oil and medicinal residues for later use;

[0048] 2. Dilute the volatile oil with absolute ethanol (1:1) for later use;

[0049] 3. Take astragalus and kudzu root and add 70% ethanol, which is 8 times that of the medicinal materials, and reflux extraction twice, each time for 2 hours, combine the ethanol extract, recover ethanol, extract and dregs for later use;

[0050] 4. Mix the medicinal residues (Chuanxiong, A...

Embodiment 3

[0055] Embodiment 3. Ningxintong preparation (oral liquid) is made of the crude drug of following weight ratio

[0056] [Prescription] Astragalus 20g Asarum 10g

[0057] Chuanxiong 20g Pueraria 15g

[0058] Holly hair 15g

[0059] [preparation method]

[0060] 1. Take 10 times the amount of Rhizoma Chuanxiong and Asarum in the prescription, add water, soak for 2 hours, refer to the "Chinese Pharmacopoeia" 2000 edition, an appendix volatile oil determination method to extract volatile oil for 10 hours, release the oil layer after cooling, and set aside;

[0061] 2. Take Radix Astragali and Radix Puerariae and add 70% ethanol, which is 10 times that of medicinal materials, reflux extraction 3 times, each time for 3 hours, combine ethanol extracts, recover ethanol, and set aside;

[0062] 3. Medicinal residues (Chuanxiong, Asarum, Astragalus, Pueraria radicis) are mixed with Ilex pubescens and extracted with water for 3 times, each time for 2 hours, and filtered. T...

Embodiment 4

[0067] Embodiment 4. clinical trial (Ning Xintong Granule)

[0068] A randomized, controlled clinical research method was adopted. The 61 patients who met the inclusion criteria were randomly divided into a treatment group of 31 cases and a control group of 30 cases, and the course of treatment for both groups was 28 days. In the treatment group, 31 cases of unstable angina pectoris (UA) were treated with Ningxintong Granules on the basis of the intensive treatment of western medicine standard. There are different degrees of improvement, and the total clinical effective rate is 90.3%, compared with the total effective rate of 63.4% in the control group (adding 30 cases of Danshen Tablets), through the chi-square test, X 2 =4.055 a , P<0.05, the difference was statistically significant. Clinically observed the improvement of various TCM syndrome scores and total scores, electrocardiogram ST segment and T wave before and after treatment, and changes in blood hs-CRP, Apo-A1, A...

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Abstract

The invention discloses a Chinese medicinal preparation for treating unstable angina pectoris and its preparation method. The preparation is prepared from Astragalus membranaceus, Ligusticum chuanxiong, Radix Puerariae, Ilex pubescens, and Herba Asari. Preparation method comprises extracting volatile oil from Ligusticum chuanxiong and Herba Asari, and collecting medicinal residue; diluting the volatile oil in anhydrous ethanol, dropping tobeta-cyclodextrin solution, stirring, and drying to obtain clathrate; extracting Astragalus membranaceus and Radix Puerariae with ethanol under reflux to obtain extractive liquid and collecting residue; mixing the above medicinal residues with Ilex pubescens, extracting with water, and concentrating the extractive liquid; mixing the above extractive liquids, concentrating to give soft extract, and making granule, pill, capsule or oral liquid with different adjuvants through conventional method. The inventive preparation is effective in dilating coronary artery, increasing coronary flow, improving blood supply to cardiac muscle, and reducing myocardial oxygen consumption.

Description

1. Technical field [0001] The invention relates to a traditional Chinese medicine preparation (named Ningxintong) and a preparation method, in particular to a Chinese medicinal preparation for treating unstable angina pectoris of coronary heart disease (chest pain and heart pain in traditional Chinese medicine) made from Chinese herbal medicines and a method for preparing the preparation method. 2. Background technology [0002] Unstable angina (UA) is a complex clinical syndrome between coronary heart disease between stable angina (SA) and acute myocardial infarction (AMI). According to the report "Nomenclature and Diagnostic Criteria of Ischemic Heart Disease" by the International Society of Cardiology and Associations and the World Health Organization (ISFC / WHO) Joint Task Force on Clinical Nomenclature Standardization, at present, initial exertional angina pectoris, worsening angina pectoris, spontaneous Chronic angina is collectively referred to as unstable angina. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P9/10
Inventor 顾宁高运军陈红锦黄霞汪静黄燕李丽李俊松
Owner NANJING HOSPITAL OF T C M
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