Water dispersible magnetic polymer microsphere, preparing method and application of the same

A technology of polymer microspheres and magnetism, which is used in medical preparations with non-active ingredients, magnetism of organic materials/organic magnetic materials, pharmaceutical formulations, etc. Separation limitations and other issues, to achieve good re-dispersion characteristics, good water dispersibility and biocompatibility, and a wide range of applications

Inactive Publication Date: 2008-02-27
GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The above method prepares magnetic microspheres, the method is simple, but the particle size or distribution of the obtained particles is irregular, the particle size is not easy to control, or the magnetic content is not high or mixed with some impurities such as emulsifiers, which are used for immunoassay, cell Separation and other areas will be greatly restricted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] (1) Preparation of template initiator (activation of template)

[0042] Take 5g SiO 2 (particle diameter 20nm) powder, add it to 200mL containing 0.1Wt% N, N-dimethylformamide (DMF) in anhydrous tetrahydrofuran (THF) solution, dropwise add 10mL thionyl chloride (SOCl 2 ), stirred overnight; the lower solid was taken out by filtration, washed 5 times with anhydrous tetrahydrofuran, and dried in vacuum at room temperature to obtain SiO 2 template initiator.

[0043] (2) template initiator grafted diblock polymer with step (1) preparation

[0044] A. Take 1mLME 6 TREN passes nitrogen for half an hour to remove oxygen; take 0.1g SiO prepared in step (1) 2 Template initiator, 20mgCuBr, 4g tert-butyl acrylate (t-BA), 1g 2-trimethylsilyl ether ethyl methacrylate (HEMA-tms), 7mL DMF were mixed, evacuated with liquid nitrogen to remove oxygen; then added 48mg pre-deoxygenated ME 6 TREN stirred and reacted at 110°C for 12 hours. After the reaction, the reaction solution was...

Embodiment 2

[0053] (1) Preparation of template initiator (activation of template)

[0054] Take 5g SiO 2 (particle size 20nm) powder, it was added to 200mL containing 1.0Wt% N, N-dimethylformamide (DMF) in anhydrous tetrahydrofuran (THF) solution, 10mL thionyl chloride (SOCl 2 ), stirred overnight; centrifuged at 2000-4000 rpm, took out the solid, washed 4 times with anhydrous tetrahydrofuran, and dried under vacuum at room temperature to obtain SiO 2 template initiator.

[0055] (2) template initiator grafted diblock polymer with step (1) preparation

[0056] A. Take 1mLME 6 TREN passes nitrogen for half an hour to remove oxygen; take the 0.15g SiO prepared in step (1) 2 Template initiator, 3.4g tert-butyl acrylate (t-BA), 1.1g 2-trimethylsilyl ether ethyl methacrylate (HEMA-tms), 6mL toluene, 18mgCuCl were mixed, and the oxygen was removed by vacuuming with liquid nitrogen ; then add 43 mg of deoxygenated ME to the reaction vial 6 TREN stirred the reaction at 110°C for 12 hours. ...

Embodiment 3

[0065] (1) Preparation of template initiator (activation of template)

[0066] Get 5g nano-titanium dioxide (TiO 2 ) (particle diameter 100nm) powder, it was added to 200mL containing 0.5Wt% N, in the anhydrous tetrahydrofuran (THF) solution of N-dimethylformamide (DMF), was added dropwise 10mL2-bromoisobutyryl bromide, stirred Overnight; take out the lower solid by filtration, wash 5 times with anhydrous tetrahydrofuran, and dry under vacuum at room temperature to obtain TiO 2 template initiator.

[0067] (2) template initiator grafted diblock polymer with step (1) preparation

[0068] A. Take 1mL PMDETA and pass argon gas for half an hour to remove oxygen; take 0.1g TiO prepared in step (1) 2 Template initiator, 24mgCuCl, 4.5g tert-butyl acrylate (t-BA), 1.5g ethyl trimethylsilyl acrylate, 8mL anisole were mixed, argon was passed through to remove oxygen; then 57.6mg of pre-deoxygenated PMDETA was stirred and reacted at 85°C for 24 hours. After the reaction, the reaction...

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Abstract

The invention discloses a water-dispersible magnetic macromolecular microball and making method and application, which is the compound of superparamagnetism center and macromolecular polymer through mould method and two-step active polymeric method, wherein the grain size of the magnetic macromolecular microball is 70-5000nm with magnetic content at 5-40% and saturated magnetified strength at 1. 0-15. 0emu / g; the magnetic macromolecular microball is nuclear shell structure with nuclear made of the composition of superparamagnetism material in the center and high molecular polymer to be ultraviolet crosslinking; the case is made of a layer of hydrophilic polymer with superparamagnetism particle distributed in the macromolecular microball, which dispersed evenly without baring and has strong response of magnetic field; the monodispersity of the macromolecular microball is good, which can be dispersed in the water; the water-dispersible magnetic macromolecular microball can be applied in the additive of compound plastic and targeting drug carrier.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a water-dispersed magnetic polymer microsphere and its preparation method and application. Background technique [0002] Magnetic polymer microspheres have both the characteristics of polymers and the magnetic responsiveness of magnetic substances. On the one hand, they can bind biologically active substances such as enzymes, cells, and antibodies through intermolecular forces, and the magnetic materials are externally wrapped with biopolymers, thereby enhancing the Biocompatibility, on the other hand, can show a strong magnetic response to an external magnetic field. Therefore, it is used as a carrier of enzymes, cells, drugs, etc. and is widely used in the fields of biomedicine, cytology, and bioengineering. In addition, it is also widely used in industrial processes such as separation and purification. [0003] For cell separation, magnetic microspheres ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/12C08L53/00C08F287/00C08K3/22H01F1/42C08K13/02C12N11/08A61K47/32
CPCY02P20/50
Inventor 胡继文赵发宝刘志雷孙建平
Owner GUANGZHOU CHEM CO LTD CHINESE ACADEMY OF SCI
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