Preparation method of carbon-nano tube-phosphorylcholine polymer composite material for blood environment
A phosphorylcholine-based, carbon nanotube technology, applied in the interdisciplinary field of disciplines, can solve the problems that limit the practical application of carbon nanotubes, stability, dispersion and biocompatibility, and achieve good biophase Capacitance, excellent dispersibility and stability, effects of chemical structure stabilization
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[0020] Example 1:
[0021] Using the multi-walled carbon nanotubes prepared by catalytic pyrolysis as the initial raw material, after acidification, acylation, and then connecting ethylene glycol, and then reacting with bromoisobutyryl bromide, grafting poly-2-(methyl bromide by ATRP method) ) acryloyloxyethylphosphorylcholine (MPC), then the water-soluble carbon nanotubes with high biocompatibility are obtained.
[0022] 1) In a 100mL single-neck round-bottomed flask equipped with a magnetic stirring rotor, add 2g of dry carbon nanotube raw materials and 20mL of 60% concentrated nitric acid by weight, heat to 120°C after 40kHz ultrasonic treatment for 30min, stir and reflux The reaction was carried out for 24hrs, filtered with 0.22μm polytetrafluoroethylene microporous membrane, washed repeatedly with deionized water until neutral, and vacuum-dried at 80°C for 24hrs to obtain acidified carbon nanotubes;
[0023] 2) In a 100 mL single-neck round-bottomed flask equipped with a...
Example Embodiment
[0030] Example 2:
[0031] Using the multi-walled carbon nanotubes prepared by catalytic pyrolysis as the initial raw material, after acidification, acylation, and then connecting ethylene glycol, and then reacting with bromoisobutyryl bromide, grafting poly-2-(methyl bromide by ATRP method) ) acryloyloxyethylphosphorylcholine (MPC), then the water-soluble carbon nanotubes with high biocompatibility are obtained.
[0032] 1) with embodiment 1;
[0033] 2) In a 100 mL single-neck round-bottomed flask equipped with a magnetic stirring rotor, add 1.5 g of acidified carbon nanotubes obtained in step 1) and 40 g of phosphorus trichloride, and after ultrasonic treatment at 80 kHz for 180 min, heat to 120° C. Reaction under reflux for 2hr, suction filtration and repeated washing to remove phosphorus trichloride to obtain acylated carbon nanotubes;
[0034] 3) with embodiment 1;
[0035] 4) In a 100 mL single-neck round-bottomed flask equipped with a magnetic stirring rotor, add 1....
Example Embodiment
[0038] Example 3:
[0039] Using the multi-walled carbon nanotubes prepared by catalytic pyrolysis as the initial raw material, after acidification, acylation, and then connecting ethylene glycol, and then reacting with bromoisobutyryl bromide, grafting poly-2-(methyl bromide by ATRP method) ) acryloyloxyethylphosphorylcholine (MPC), then the water-soluble carbon nanotubes with high biocompatibility are obtained.
[0040] 1) with embodiment 1;
[0041] 2) In a 100 mL single-neck round-bottomed flask equipped with a magnetic stirring rotor, add 1.5 g of acidified carbon nanotubes obtained in step 1) and 6 g of phosphorus pentachloride, and after ultrasonic treatment at 120 kHz for 180 min, heat to 120° C. Reaction under reflux for 80hr, suction filtration and repeated washing to remove phosphorus pentachloride to obtain acylated carbon nanotubes;
[0042] 3) with embodiment 1;
[0043] 4) In a 100 mL single-neck round-bottomed flask equipped with a magnetic stirring rotor, a...
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