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Preparation method of carbon-nano tube-phosphorylcholine polymer composite material for blood environment

A phosphorylcholine-based, carbon nanotube technology, applied in the interdisciplinary field of disciplines, can solve the problems that limit the practical application of carbon nanotubes, stability, dispersion and biocompatibility, and achieve good biophase Capacitance, excellent dispersibility and stability, effects of chemical structure stabilization

Inactive Publication Date: 2008-05-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been a series of reports on polymer modification of carbon nanotubes by atom transfer radical polymerization, and the polymers used include N, N-dimethylacrylamide, N-isopropylacrylamide, (meth)acrylic acid tert-butyl ester, poly-p-chloromethylstyrene, polyvinylpyrrolidone, (methyl), styrene, methyl acrylate, and hydroxyethyl (meth)acrylate, the strategy of these grafted hydrophobic polymers to enhance The stability of carbon nanotubes in organic solvents has been improved, but the stability, dispersion and biocompatibility in aqueous solution and physiological environment have not been resolved. All these unfavorable factors have greatly limited the application of carbon nanotubes in biomedicine. practical applications in the field

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The multi-walled carbon nanotubes prepared by catalytic pyrolysis method are used as the initial raw material, after acidification and acylation, ethylene glycol is connected, and then reacted with bromoisobutyryl bromide, and poly-2-(methyl ) acryloyloxyethyl phosphorylcholine (MPC), then obtain highly biocompatible water-soluble carbon nanotubes.

[0022] 1) In a 100mL single-necked round-bottom flask equipped with a magnetic stirring rotor, add 2g of dry carbon nanotube raw material and 20mL of 60% concentrated nitric acid by weight, treat with 40kHz ultrasonic waves for 30min, heat to 120°C, stir and reflux React at low temperature for 24 hours, filter with 0.22 μm polytetrafluoroethylene microporous membrane, wash repeatedly with deionized water until neutral, and vacuum dry at 80°C for 24 hours to obtain acidified carbon nanotubes;

[0023] 2) Add 1.5 g of acidified carbon nanotubes and 8 g of thionyl chloride obtained in step 1) into a 100 mL single-necked round-...

Embodiment 2

[0031] The multi-walled carbon nanotubes prepared by catalytic pyrolysis method are used as the initial raw material, after acidification and acylation, ethylene glycol is connected, and then reacted with bromoisobutyryl bromide, and poly-2-(methyl ) acryloyloxyethyl phosphorylcholine (MPC), then obtain highly biocompatible water-soluble carbon nanotubes.

[0032] 1) with embodiment 1;

[0033] 2) Add 1.5 g of acidified carbon nanotubes and 40 g of phosphorus trichloride obtained in step 1) into a 100 mL single-necked round-bottomed flask equipped with a magnetic stirring rotor. After 180 min of ultrasonic treatment at 80 kHz, heat to 120 ° C, stir and Reaction under reflux for 2hr, suction filtration and repeated washing to remove phosphorus trichloride, to obtain acylated carbon nanotubes;

[0034] 3) with embodiment 1;

[0035] 4) In a 100mL single-necked round-bottomed flask equipped with a magnetic stirring rotor, add 1.1g of carbon nanotubes with hydroxyl groups on the...

Embodiment 3

[0039] The multi-walled carbon nanotubes prepared by catalytic pyrolysis method are used as the initial raw material, after acidification and acylation, ethylene glycol is connected, and then reacted with bromoisobutyryl bromide, and poly-2-(methyl ) acryloyloxyethyl phosphorylcholine (MPC), then obtain highly biocompatible water-soluble carbon nanotubes.

[0040] 1) with embodiment 1;

[0041] 2) Add 1.5 g of acidified carbon nanotubes and 6 g of phosphorus pentachloride obtained in step 1) into a 100 mL single-necked round-bottomed flask equipped with a magnetic stirring rotor. After 180 min of ultrasonic treatment at 120 kHz, heat to 120 ° C, stir and Reaction under reflux for 80 hr, suction filtration and repeated washing to remove phosphorus pentachloride to obtain acylated carbon nanotubes;

[0042] 3) with embodiment 1;

[0043] 4) In a 100mL single-necked round-bottomed flask equipped with a magnetic stirring rotor, add 1.1 g of carbon nanotubes with hydroxyl groups ...

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PUM

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Abstract

The invention discloses a method used for preparing a composite material of carbon nano-tube and phosphorylcholine base polymer used in blood environment. The method leads the surface of the carbon nano-tube to have a specified evocating group after treatment, and then atom is used for transferring radical polymerization to cause 2-(methyl) propylene acyloxy ethyl choline phosphate monomer polymerization, which obtains grafting 2-(methyl) propylene acyloxy ethyl choline phosphate carbon nano-tube. The method is simple and easy and has strong controllability, and the obtained carbon nano-tube protected by the phosphorylcholine polymer has good dissolubility, stability and high biocompatibility in water physiological environment. As nano-biomaterials, the carbon nano-tube protected by the phosphorylcholine polymer provided by the invention has considerable application prospect in the field of drug delivery, gene transmission, molecular diagnosis and detection, separation of biomolecules, and biosensor, etc.

Description

technical field [0001] The invention relates to a method for preparing a carbon nanotube-phosphorylcholine-based polymer composite material used in a blood environment, and belongs to the interdisciplinary field of materials, biology, physics, chemistry and other disciplines. Background technique [0002] Carbon nanotubes, discovered in 1991, are a type of tubular carbon material with a perfect graphite structure, with diameters generally ranging from a few nanometers to tens of nanometers. Carbon nanotubes have excellent electrical conductivity, electromagnetic properties and excellent mechanical properties, and their excellent comprehensive properties have aroused great research interest in the field of biomedicine. However, industrially large-scale synthesized carbon nanotubes often contain various impurities including catalysts and various amorphous carbons, which make carbon nanotubes potentially cytotoxic in the biomedical field. Moreover, due to the huge specific sur...

Claims

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Application Information

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IPC IPC(8): C01B31/02
Inventor 计剑徐建平竺磊泽金桥沈家骢
Owner ZHEJIANG UNIV
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