Method for preparing medical knee joint semilunar cartilage

A meniscus, knee joint technology, applied in knee joints, elbow joints, joint implants, etc., can solve problems such as insufficient source, material aging, wear and tear, and achieve good patient tolerance, good mechanical properties, immunogenicity small effect

Inactive Publication Date: 2008-07-02
THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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Problems solved by technology

[0003] At present, the tissue engineering materials used for meniscus transplantation include natural biomaterials and synthetic biomaterials mainly include: ① polyvinyl alcohol-hydrogel (PVA-H); ② gelatin sponge; ③ collagen; ④ alginate; ⑤ Polyglycolic acid (PGA); ⑥ polylactic acid (PLA); ⑦ small intestinal submucosa; ⑧ polyglycolic acid and polylactic acid copolymer; ⑨ fibrin gel, etc.; The fixation of the prosthesis in the joint, the problems of material aging, wear, and degradation of biomechan

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  • Method for preparing medical knee joint semilunar cartilage

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Embodiment Construction

[0018] The following structural drawings further illustrate the present invention.

[0019] Referring to accompanying drawing 1, 1 among the figure is the outer edge of silk meniscus, and 2 is the inner edge of silk meniscus, and 3 is the fixing cord of silk meniscus. When making, first select high-quality silk, and crochet the silk in the middle part into a taper-shaped silk meniscus whose outer edge 1 is thicker than the inner edge 2, and the silk reserved at both ends is the fixing cable 3. Then the silk meniscus was placed in 0.5% sodium carbonate (Na 2 CO 3 ) solution heated to 100°C for half an hour, taken out and rinsed with water, and then placed in reconstituted 0.5% sodium carbonate (Na 2 CO 3 ) solution, heated to 100°C for half an hour, taken out, rinsed with water, and dried, so that the silk was degummed into a silk protein fiber meniscus. Then place the fibroin fiber meniscus in a mold with the same shape as the knee joint meniscus and inject type I collagen...

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Abstract

The invention relates to a preparation method of a medical knee joint meniscus, the steps mainly include that: silk with the high quality is firstly selected to be crocheted into a silk meniscus which takes a shape of wedge, the outer edge of the silk meniscus is thicker than the inner edge, and the medical knee joint meniscus can be prepared by degumming, drying, silk protein fiber-collagen compound shaping and other steps. The invention has the advantages of convenient production, low cost and so on, when in use, the transplantation operation is simple, convenient, safe and reliable, the tolerance of patients is good and the immunogenicity is small. As the silk protein fiber after the removal of sericin has good mechanical properties and biocompatibility, the invention can bear the functions of knee joint stabilization, load conduction, articular cartilage protection and lubrication of the natural meniscus at the early stage of the transplantation, at the same time, the invention has the function of a tissue engineering scaffold, and can support the cell growth and blood vessel growth at the advanced stage of the transplantation and be gradually degraded and absorbed along with the regeneration of the real natural meniscus, so the invention provides a new choosing path for the treatment of the patients with the seriously damaged and apraxia knee joint meniscus.

Description

technical field [0001] The invention relates to a preparation method of a medical meniscus, in particular to a preparation method of a medical degradable and absorbable knee joint meniscus, belonging to the field of prosthesis materials. Background technique [0002] The meniscus is a fibrous cartilage located in the knee joint, which has important functions such as absorbing shock, transmitting load, nourishing articular cartilage, lubricating and increasing joint contact area, and maintaining joint stability. The outer edge of the meniscus is thick and the inner edge is sharp and thin. The peripheral part has sufficient blood supply, while the rest part has poor blood supply and lacks the ability to repair and regenerate. The follow-up survey found that the size of the meniscectomy was closely related to the risk of knee osteoarthritis. After the meniscus is severely damaged and resected, the protective effect of the meniscus on the articular cartilage is lost, and the de...

Claims

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Application Information

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IPC IPC(8): A61L27/26A61L27/24A61L27/58A61F2/38
Inventor 蒋青刘和风王骏飞陈东阳王锋
Owner THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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