Method for preparing polymer nano micelle by water solution polymerization self-emulsification method

An aqueous solution polymerization and nano-micelle technology, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of drug or human injury, low concentration, etc., and achieve good results, easy operation, and low cost.

Inactive Publication Date: 2008-07-09
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The presence of organic solvents may cause harm to drugs or the human body
The second problem is that the concentration is too low
However, the above-mentioned methods all use organic solvents, and the residual organic solvents will cause harm to medicine or human body

Method used

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  • Method for preparing polymer nano micelle by water solution polymerization self-emulsification method
  • Method for preparing polymer nano micelle by water solution polymerization self-emulsification method

Examples

Experimental program
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Effect test

Embodiment 1

[0023] Embodiment 1. styrene / maleic anhydride mol ratio is 1.5: 1, and adding butyl acrylate (accounting for 5% of all monomer molar consumptions) is the 3rd monomer, with potassium persulfate as initiator (consumption is unit 2% of the total moles of the monomer), with deionized water as the reaction solvent, and the weight percentage of the monomer in the aqueous solution was 15%, and reacted at 60° C. for 20 hours to ensure that all the monomers were completely reacted. Its polymer micelle solution is shown in accompanying drawing 1-A.

Embodiment 2

[0024] Embodiment 2. styrene / maleic anhydride mol ratio is 1.5: 1, and add hydroxyethyl acrylate (accounting for 10% of all monomer molar consumption), butyl acrylate (accounting for all monomer molar consumption 10%), P-divinylbenzene (accounting for 1.5% of the molar amount of all monomers) is a crosslinking agent, potassium persulfate is used as an initiator (the amount is 1.5% of the total molar amount of monomers), and deionized water is used as a reaction solvent, and The weight percent of the monomers in the aqueous solution was 30%, and the reaction was carried out at 60° C. for 20 hours to ensure that all the monomers were completely reacted. Its polymer micelle solution is shown in accompanying drawing 1-B.

Embodiment 3

[0025] Embodiment 3. styrene / maleic anhydride mol ratio is 1.5: 1, and adding hydroxyethyl acrylate (accounting for 10% of all monomer molar consumption) is the third monomer, with potassium persulfate as initiator (consumption is 1% of the total moles of the monomers), with deionized water as the reaction solvent, and the weight percentage of the monomers in the aqueous solution was 25%, and reacted at 60° C. for 20 hours to ensure that all the monomers were completely reacted. Its polymer micelle solution is shown in accompanying drawing 1-C.

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Abstract

The invention relates to a process for preparing polymers nano-micelles with a method of water solution polymerization self-emulsifying method, which belongs to the technical field of high molecule polymerization. The invention utilizes strong alternating polymerization tendency of styrene monomer / maleic anhydride monomer, and / or the participation of (metyl group) 2-hydroxyethyl acrylate and / or the other (metyl group) alkyl acrylate, and / or p-divinyl benzene bifunctional monomer, any emulsifying agent, inorganic salt and organic solvent are not added, crosslinking type or non crosslinking type green and clean polymeric compound namely nano-micelle whose particle diameter can be adjusted and controlled, and distribution is even is directly prepared in water solution through radical polymerization by utilizing potassium peroxodisulfate to be initiating agent, which is directly applied in the loading and releasing of medicament, catalysis, load and the other aspects. The steps of purification and micellization of polymers are omitted by the invention, organic solvent is not brought in, and pollution can not be brought, the operation is simple and convenient, and the production cost is low, polymers nano-micelles which has various sizes, structures and performances can be obtained through adjusting the species, proportion and dosage of initiating agent of hydrophilic / hydrophobic monomer.

Description

technical field [0001] The invention discloses a method for preparing polymer nano micelles by an aqueous solution polymerization self-emulsification method, which belongs to the technical field of polymer polymerization. The invention relates to a "green and clean" polymer nanomicelle, the preparation process is simple and pollution-free, and its application includes the existing and potential applications of the nanomicelle such as drug load release, polymer material modification and chemical reaction loading. Background technique [0002] Polymer nanomicelle is a new type of multifunctional nanomaterial with nanometer or submicron size. It is a type of microphase separation of amphiphilic polymers in selective solvents, which has a solvate core and a solvation shell. self-assembled structure. The driving forces leading to the formation of solvophobic domains include hydrophobic interaction, electrostatic interaction, hydrogen bonding or metal complexation. Compared with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F212/08C08F2/22A61K47/32C08F222/08C08F220/10C08F212/36
Inventor 江金强冯艳刘晓亚张胜文陈明清倪忠斌
Owner JIANGNAN UNIV
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