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Technique for separating and purifying L-lactic acid

A technology of separation and purification, a new process, applied in the field of separation and preparation of high-purity L-lactic acid, can solve the problems of large water consumption, easy decomposition, large amount of acid and alkali, etc., to reduce the discharge of acid and alkali, the technology is simple and easy, Good cleaning effect

Inactive Publication Date: 2008-08-06
江苏道森生物化学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Invention ideas: The present invention intends to use continuous separation technology to overcome the large amount of resin used in fixed bed exchange technology, low utilization rate, large amount of acid and alkali used in detergent, eluent and resin regeneration, environmental pollution, and discharge concentration. Low water consumption, only intermittent operation, not suitable for industrial production; the membrane separation technology is proposed to use the microfiltration membrane to remove macromolecules such as bacteria and protein, and then use the nanofiltration membrane to achieve the purpose of concentration; it is proposed to adopt Molecular distillation technology overcomes the shortcomings of poor heat resistance and easy decomposition of lactic acid distilled by traditional vacuum distillation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The lactic acid fermentation liquid (lactate concentration: 30g / L) pretreated by centrifugation and decolorization is pumped into the ultrafiltration equipment to remove protein and other macromolecular substances in the fermentation liquid. The molecular weight cut-off of the ultrafiltration membrane is 10000Dalton. After diluting the supernatant to 7g / L, adjust the pH value to 2.5, and pump it into the continuous ion exchange system equipped with anion exchange resin 301 type. The continuous ion exchange system is composed of 18 ion exchange columns, and the adsorption section is 6. There are 3 cleaning sections, 3 elution sections, and 6 regeneration sections. Each ion exchange column was filled with 100 g weakly basic anion resin, and the adsorption flow rate was 15 mL / min. The washing liquid is a sodium chloride solution with a pH of 2 and 0.05 mol / L, and the washing flow rate is 20 mL / min. The eluent is 0.5M hydrochloric acid solution, the elution flow rate is 10...

Embodiment 2

[0020] The lactic acid fermentation liquid (lactate concentration: 100g / L) pretreated by centrifugation and decolorization is pumped into the ultrafiltration equipment to remove protein and other macromolecular substances in the fermentation liquid. The molecular weight cut-off of the ultrafiltration membrane is 5000Dalton. After diluting the supernatant to 50g / L, adjust the pH value to 2.5, and pump it into a continuous ion exchange system equipped with anion exchange resin 302. The continuous ion exchange system is composed of 30 ion exchange columns, and the adsorption section is 10. There are 5 cleaning sections, 5 elution sections, and 10 regeneration sections. Each ion exchange column was filled with 100 g weakly basic anion resin, and the adsorption flow rate was 12 mL / min. The cleaning liquid is a sodium chloride solution with a pH of 4 and 0.2 mol / L, and the cleaning flow rate is 10 mL / min. The eluent is 0.1M sulfuric acid solution, the elution flow rate is 5mL / min, ...

Embodiment 3

[0022] The lactic acid fermentation liquid (lactate concentration: 20g / L) pretreated by centrifugation and decolorization is pumped into the ultrafiltration equipment to remove protein and other macromolecular substances in the fermentation liquid. The molecular weight cut-off of the ultrafiltration membrane is 8000Dalton. After diluting the supernatant to 5g / L, adjust the pH value to 2.5, and pump it into the continuous ion exchange system equipped with anion exchange resin 311 type. The continuous ion exchange system is composed of 6 ion exchange columns, and the adsorption section is 2. There is 1 cleaning section, 1 elution section, and 2 regeneration sections. Each ion exchange column is filled with 100 g weakly basic anion resin, and the adsorption flow rate is 10 mL / min. The washing liquid is ammonium chloride solution with pH 10 and 0.01mol / L, and the washing flow rate is 8mL / min. The eluent is 2M sulfuric acid solution, the elution flow rate is 4mL / min, and the separ...

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Abstract

The invention discloses a new technology for separating and purifying L-lactic acid with continuous ion exchange, membrane separation and molecular distillation. Centrifuged and decolorated lactic acid fermentation liquid is pumped into an ultrafiltration apparatus to remove proteins; clear liquid with a lactate concentration of 10-50g / L is then pumped into a continuous ion exchange system filled with anion exchange resin for adsorption; an inorganic salt solution with a concentration of 0.001-0.2M is used for impurity washing and an acid solution with a concentration of 0.1-2M is used for elution; nano-filtration technology is employed for synchronous concentration and desalination of the ion exchange eluent; high-purity and high-quality L-lactic acid can be obtained after treatment with molecular distillation means in the end. The technology has the advantages of low equipment investment, strong continuous operability, low production cost, high product purity, easy scale production, etc.

Description

technical field [0001] The invention relates to the separation and preparation technology of high-purity L-lactic acid, belonging to the field of biological product processing. Background technique [0002] Lactic acid is an important organic acid, which has many uses in food, medicine, chemical industry, etc., especially as a monomer for the synthesis of degradable material polylactic acid, which has attracted widespread attention. Lactic acid used in the food and pharmaceutical industries is mainly produced by fermentation. When lactic acid is produced by fermentation, the traditional lactic acid separation method is: first convert the lactic acid produced by fermentation into calcium lactate, and then react with calcium lactate and sulfuric acid to obtain lactic acid , and refined by decolorization and ion exchange. In this process, the process flow is long, the operating conditions are poor, and solid waste treatment is difficult. More importantly, due to the high solubi...

Claims

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Application Information

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IPC IPC(8): C07C59/08C07C51/42C12P7/56
Inventor 白涵许兵孙扬
Owner 江苏道森生物化学有限公司
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