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Rumen bypass becholine microcapsule and preparation technique

A choline chloride, preparation technology, applied in the direction of microcapsules, capsule delivery, molding or processing of animal feed, etc., can solve the problems of pressure deformed capsule core exposure, affecting product absorption, deformation and rupture, etc., to achieve coating Uniform thickness, increased absorption rate, and rounded particles

Inactive Publication Date: 2010-06-16
WUHAN POLYTECHNIC UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Considering the problems of choline chloride moisture absorption and vitamin destructiveness, the application uses silicon dioxide as a carrier to solve the problem of moisture absorption; considering the characteristics of the rumen of ruminants, it is hoped that hydrogenated vegetable oil will be used to coat the capsule core to achieve Reduce the absorption of choline chloride in the rumen, but there is a problem of poor solidity when using hydrogenated vegetable oil as a coating. The final product of this application is a cylindrical solid particle with a certain length and diameter, and hydrogenated vegetable oil is used as a coating. Poor solidity, it will be deformed and broken under a little external pressure
Considering the cost and other reasons, the packaging of animal feed additives is usually relatively simple, such as directly using a large amount of packaging such as sacks or plastic bags, which is not as fine as the packaging of human medicines. Therefore, it is required to ensure the shape of such products during packaging, transportation and storage. Stability, no pressure deformation, coating damage, capsule core exposure, etc., otherwise it will seriously affect the digestion of the product in the rumen and the absorption in the small intestine, and the product coated with hydrogenated vegetable oil alone is difficult to withstand packaging and transportation , The pressure generated during storage, most of the products will be deformed and damaged to varying degrees, seriously affecting their rumen passing effect, the above reasons directly lead to the inability to realize actual production and sales

Method used

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  • Rumen bypass becholine microcapsule and preparation technique

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Core material preparation:

[0026] Choline chloride 40kg, starch 10kg, microcrystalline cellulose 5kg, footstone 45kg and 1.5% sodium carboxymethylcellulose aqueous solution 30000ml are mixed in proportion, then granulated by a swing granulator, and then shot blasted by a shot blasting machine. Dry (equipment: FLP type fluidized granulation coating dryer), sieve, the particle size of the sieve is between 16-40 mesh, set aside.

[0027] 2. Preparation of coating solution:

[0028] Add 12g acrylic resin IV to every 100ml95% alcohol solution, stir to make it dissolve to make acrylic resin IV solution; add 3g chitosan to every 100ml4% acetic acid solution, stir to make it dissolve to make chitosan solution; Add 2.5g of ethyl cellulose to it, and stir to dissolve it to make an ethyl cellulose solution.

[0029] 3. Preparation of microcapsules:

[0030] The above-mentioned granular core material is sent into the coating chamber of the fluidized bed,

[0031] (1) Adjus...

Embodiment 2

[0035] 1. Core material preparation:

[0036] Choline chloride 35kg, starch 5kg, microcrystalline cellulose 10kg, footstone 50kg, 1.5% sodium carboxymethylcellulose aqueous solution 30000ml are mixed in proportion, and all the other are with embodiment 1.

[0037] 2. Preparation of coating solution:

[0038] With embodiment 1.

[0039] 3. Preparation of microcapsules:

[0040] Send the above-mentioned granular core material into the coating chamber of the fluidized bed, and spray acrylic resin IV solution, ethyl cellulose solution, chitosan in sequence in the order of inner layer coating, additional layer coating, and outer layer coating. solution, wherein, the spraying amount of the inner layer coating is 3% of the mass of the core material as the acrylic resin IV after drying as the inner layer coating, and the spraying amount of the additional layer coating is that of ethyl cellulose after drying as the additional layer coating Clothing is 3% of core material quality, an...

Embodiment 3

[0042] 1. Core material preparation:

[0043] Choline chloride 45kg, starch 8kg, microcrystalline cellulose 7kg, footstone 40kg, 1.5% sodium carboxymethylcellulose aqueous solution 30000ml are mixed in proportion, and all the other are with embodiment 1.

[0044] 2. Preparation of coating solution:

[0045] With embodiment 1.

[0046] 3. Preparation of microcapsules:

[0047] Send the above-mentioned granular core material into the coating chamber of the fluidized bed, and spray acrylic resin IV solution, ethyl cellulose solution, chitosan in sequence in the order of inner layer coating, additional layer coating and outer layer coating Solution, wherein, the spraying amount of the inner layer coating is the dried acrylic resin IV as the inner layer coating is 5% of the core material quality, and the spraying amount of the outer layer coating is the dried chitosan as the outer layer coating 3% of the mass of the core material, the spraying amount of the additional layer coat...

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Abstract

The invention relates to a through-rumen choline chloride microcapsule and the preparation technique thereof, and solves the problems that choline chloride has a poor effect through the rumen, ruminants have a low intestinal absorption rate and packing, storage and transportation are not easy. The technical proposal is as follows: choline chloride with a mass percentage of 35 to 40 percent is adopted as the main active ingredient and used as the core material, acrylics IV is used as the internal coating of the core material, chitosan is used as the external coating, and the mass of the internal and external coatings is both 3 to 5 percent of the mass of the core material. The through-rumen choline chloride microcapsule can guarantee that a good moisture resistance is ensured during packing, storage and transportation, deformation and damage fail to occur due to compression, the goal of a slow release can be achieved in the rumen and the intestinal absorption rate of choline chloride isimproved.

Description

technical field [0001] The invention relates to a rumen-passed choline chloride microcapsule and a preparation process thereof. Background technique [0002] Choline is one of the B vitamins. In the growth and metabolism of livestock and poultry, choline is the donor of methyl, and is the important bioactive substance in biological tissues - acetylcholine, phospholipids, ceramide, etc. Important component; it can not only improve the utilization rate of amino acids in livestock and poultry, promote fat metabolism, prevent fat accumulation in liver and kidney and tissue deterioration, but also enhance the physical fitness and disease resistance of livestock and poultry, and promote the growth of livestock and poultry . [0003] As an animal feed additive, choline chloride has been widely used in the feeding of various monogastric animals. For example, as a full-price compound feed for chickens in different physiological stages, it can increase the egg production rate of bree...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/38A61K31/14A61K9/50A23K1/16A61P3/02A61K47/32A23K20/10A23K20/163A23K40/10
Inventor 王春维赵胜军侯永清陈东东李建文刘昌杜
Owner WUHAN POLYTECHNIC UNIVERSITY