Bone repair material containing nano hydroxylapatite/collagen particle and preparation thereof

A nano-hydroxyapatite and bone repair technology, applied in medical science, prosthesis and other directions, can solve the problems of inconvenient application, no observation of long-term effect, etc., and achieves easy processing, no cytotoxicity, and a wide range of sources. Effect
CN101297980AActive Publication Date: 2008-11-05BEIJING ALLGENS MEDICAL SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING ALLGENS MEDICAL SCI & TECH
Publication Date
2008-11-05

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Abstract

The invention relates to a bone repair material containing nano hydroxyapatite / collagen particles, and a preparation method thereof. The invention provides a bone repair material which comprises: 1 to 2 parts by weight of the nano hydroxyapatite / collagen particles, 1 part by weight of chitosan and 2 to 3 parts by weight of Beta-sodium glycerophosphate (which is supplemented by the weight proportion of the components). The invention also provides a preparation method of the bone repair material; the bone repair material is placed at 37 DEG C or injected into human body, thus forming in-situ gelatin. The bone repair material provided by the invention not only can retain the characteristics of modeled natural bone structure, but also ensures the new performance of syringeability of the material and has temperature sensitivity, thus being applicable to minimal invasive surgery and convenient for clinical application.
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Description

technical field

[0001] The invention relates to an injectable bone repair material containing nano-hydroxyapatite / collagen particles and a preparation method thereof. Background technique

[0002] Chitosan is a natural biological polysaccharide with a wide range of sources, no cytotoxicity, good biocompatibility and no antigenicity, absorbable and easy to process. It has been used in artificial skin, absorbable sutures, hemostatic sea Cotton, anti-adhesion agent and drug sustained-release capsules, etc.

[0003] According to the interaction force between chitosan solution ions, in 2000, Chenite et al. (AChenite, C Chaput, D Wang, et al.Novel injectable neutral solutions of chitosan from biodegradable gels in situ. 2161) developed a thermosensitive chitosan hydrogel. The specific method is to add polyalcohol salts such as β-glycerophosphate sodium (GP) to the chitosan aqueous solution. Under the synergy of hydrogen bonds, electrostatic interactions and hydrophobic interacti...

Claims

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