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Nano-hydroxyapatite glycerin cement, preparation method and application in toothpaste thereof

A technology of nano-hydroxyapatite and glycerin, which is applied in the fields of chemical instruments and methods, dentistry, phosphorus compounds, etc., can solve the problems of increasing product cost, complex preparation and dispersion technology, and affecting popularization and application, and achieves high utilization rate and low cost of raw materials. Inexpensive and easy to obtain, the effect of simple process

Inactive Publication Date: 2009-01-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although toothpaste containing nano-hydroxyapatite can be prepared according to the above-mentioned technologies, they cannot simultaneously meet the requirements of cheap raw materials, simple preparation, small particle size (maximum size less than 50nm), good dispersion, and convenient addition.
Toothpaste is a mass consumer product with low price, complicated preparation and dispersion technology, and unnecessary additives in toothpaste will increase product cost and affect its popularization and application

Method used

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  • Nano-hydroxyapatite glycerin cement, preparation method and application in toothpaste thereof
  • Nano-hydroxyapatite glycerin cement, preparation method and application in toothpaste thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]In the first step, 0.9 kg of calcium hydroxide is pulverized and passed through a 300-mesh sieve to obtain calcium hydroxide powder; a mass ratio of 0.6: 1 is mixed with ethanol and glycerin to make 12 kg of ethanol-glycerin mixture; the powder Add to ethanol-glycerin mixture, stir evenly at room temperature to make component A;

[0034] In the second step, add the concentrated phosphoric acid solution into ethanol, stir evenly to make component B, wherein the mass ratio of phosphoric acid to ethanol is 1:10;

[0035] The third step is to put component A into a 25L reaction kettle with a reflux device, stir and heat up to a slight boil, and after 30 minutes, add component B into the reaction kettle at a speed of 2-20ml / min first and then slowly, and wait for the reaction Stop adding when the pH value of the mixed solution in the still is stable at 8.5, continue to react for 4 hours, and keep a little boiling and stirring in the reaction process;

[0036] In the fourth s...

Embodiment 2

[0041] The first step, after mixing calcium hydroxide 0.85kg and strontium hydroxide octahydrate 0.15kg, pulverize, cross 300 mesh sieves, obtain the powder of calcium hydroxide and strontium hydroxide octahydrate mixture; Be 1: 1 by mass ratio Proportionally mix ethanol and glycerin to make 12kg of ethanol-glycerin mixture; add the powder into the ethanol-glycerin mixture, stir evenly at room temperature to make component A;

[0042] In the second step, the concentrated phosphoric acid solution is added to ethanol, and stirred evenly to make component B, wherein the mass ratio of phosphoric acid to ethanol is 1:5;

[0043] The third step is to put component A into a 25L reaction kettle with a reflux device, stir and heat up to a slight boil, and after 30 minutes, add component B into the reaction kettle at 2-10ml / min first and then slowly, and wait for the reaction Stop adding when the pH value of the mixed solution in the still is stable at 8.0, continue to react for 4 hours...

Embodiment 3

[0047] In the first step, 0.7 kg of calcium oxide is pulverized and passed through a 300-mesh sieve to obtain calcium oxide powder; the mass ratio is 1:1 by mixing ethanol and glycerin to make 12 kg of ethanol-glycerin mixture; adding the powder to ethanol In the glycerin mixture, stir evenly at room temperature to make component A;

[0048] In the second step, glycerin and ethanol are mixed in a ratio of 0.5:1 by mass to obtain a glycerol-ethanol mixture; the concentrated phosphoric acid solution is added to glycerol-ethanol, and stirred evenly to make component B, wherein the mass of phosphoric acid and glycerol-ethanol mixture The ratio is 1:10;

[0049] The third step is to put component A into a 25L reaction kettle with a reflux device, stir and heat up to a slight boil, and after 30 minutes, add component B into the reaction kettle at 2-10ml / min first and then slowly, and wait for the reaction Stop adding when the pH value of the mixed solution in the still is stable at...

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Abstract

The invention relates to a preparation method for a nanometer hydroxyapatite glycerin cement, which comprises: step one, calcium agents are grinded and screened by a screen with 300 meshes to obtain calcium powders, ethanol and glycerol are mixed by the mass ratio of 0.1 to 1.5: 1, and are added with the calcium powders to stir evenly to obtain A component; wherein, the calcium content is 1 to 20wt percent; step two, the ethanol and the glycerol are mixed by the mass ratio of 0 to 1:1, and are added with concentrated phosphoric acid solution with 85 percent of mass percent concentration by the mass ratio of 1:2 to 10 to stir evenly to obtain B component; step three, the A component is loaded in a reaction kettle to be stirred and heated up to slightly boil for 20 to 30 minutes, is added with the B component into the reaction kettle to stop the adding when the PH value of the mixture reaches 8 to 8.5, the reaction continues for 3 to 6 hours under the slight boiling; step four, the mixture solution in the reaction kettle is distilled to the mixture solution with ethanol content less than 0.5 wt percent to obtain the nanometer hydroxyapatite glycerin cement. The method has simple process, the nanometer hydroxyapatite in the product has small particle diameter and can be used for preparing toothpaste.

Description

technical field [0001] The invention relates to a nano-hydroxyapatite glycerin glue, a preparation method thereof and an application in toothpaste. Background technique [0002] Caries and periodontal disease are two frequently occurring oral diseases that seriously endanger human health. Using toothpaste to prevent and treat oral diseases is a convenient and effective way. However, most of the anti-caries toothpastes on the market are fluoride-containing toothpastes. Fluorine can reduce the solubility of tooth enamel, promote the remineralization of enamel, affect the growth of oral bacteria and the metabolism of sugar, and have obvious effects on the prevention and treatment of caries and periodontal disease. But fluorine is also a trace element that the human body is very sensitive to. There is not much difference between the amount that meets the needs and the amount that causes poisoning. Excessive intake of fluorine can lead to yellow-brown dental fluorosis, and in se...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61Q11/00C01B25/32
Inventor 王迎军喻新平魏坤陈晓峰
Owner SOUTH CHINA UNIV OF TECH
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