Porous integral medium, preparation and use thereof

A medium and overall technology, applied in chemical instruments and methods, other chemical processes, alkali metal oxides/hydroxides, etc., can solve the problem of uneven distribution of surface functional groups, inaccurate control of pore size distribution, and reduced mechanical properties of materials and other problems, to achieve the effect of excellent permeability, excellent mechanical stability and high porosity

Inactive Publication Date: 2009-01-21
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of the preparation methods of organic polymer monolithic media are solution polymerization (Anal.Chem.78(2006)5729-5735; Journal of Chromatography A.728(1996)139-147) based on free radical polymerization reaction mechanism. The limitations lead to the fact that the internal structure of the material is a microsphere stacking structure and the porosity is not high. For example, the porosity of the traditional polymethacrylate monolithic column can only reach 65%. After this value, the mechanical properties of the material will decrease. reduce or even cause the column to collapse
In addition, the inhomogeneous internal structure of the material leads to the inaccurate control of the pore size distribution and the uneven distribution of surface functional groups, resulting in low efficiency of the separation column.
These defects limit the application of this material as a substrate for bioreactors and for the separation and purification of biomacromolecules.

Method used

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  • Porous integral medium, preparation and use thereof
  • Porous integral medium, preparation and use thereof
  • Porous integral medium, preparation and use thereof

Examples

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Effect test

preparation example Construction

[0025] Preparation of the first part of porous monolithic media

[0026] The invention adopts the super-concentrated emulsion polymerization method to control the composition of the super-concentrated emulsion in the reaction system and the phase separation process, thereby preparing a porous monolithic medium with a nanowire network skeleton structure. The porous monolithic medium has a regular nanowire network skeleton and a micron-scale through-hole structure, the skeleton size is between 50-500nm, the porosity is between 60%-95%, and the through-pore diameter is between 1-100μm, which can be continuously adjusted . The porous monolithic medium has an internal pore structure arranged in an orderly manner, and the pores communicate with each other, and the form can be a continuous rod or a continuous integral film. The specific surface area of ​​the porous monolithic medium of the present invention is large, between 100-350m 2 g -1 , with excellent permeability and excell...

Embodiment 1

[0037] Embodiment 1: Preparation of glycidyl methacrylate monolithic separation medium

[0038] At room temperature, 14.5g glycidyl methacrylate (GMA), 6.70g ethylene glycol methacrylate (EDMA) and 2.68g Synperonic PEL 121 were placed in a dry three-necked flask equipped with mechanical stirring at 550rpm Stir, and then 95ml containing 0.2% potassium persulfate (quality) and 2% CaCl 2 ·6H 2 O (mass) deionized aqueous solution was added dropwise into a three-necked flask by dropping while stirring, and the dropping speed was controlled to prevent phase separation, and the ultra-concentrated emulsion could be obtained by continuing for 20-30 minutes.

[0039] Transfer the ultra-concentrated emulsion into a centrifuge test tube, centrifuge at 300r / min for 2min to remove oxygen, and then pass in nitrogen gas to seal for 15min. Then, put the mixed solution into a dry mold, seal it and place it in a water bath at 55°C for 48 hours, then use excess deionized water and ethanol to wa...

Embodiment 2

[0041] Embodiment 2: Preparation of glycidyl methacrylate monolithic separation medium

[0042] At room temperature, 13.2g of glycidyl methacrylate (GMA), 7.20g of ethylene glycol methacrylate (EDMA) and 3.68g of Pluronic F127 were placed in a dry three-necked flask equipped with mechanical stirring at a speed of 550rpm. Stir, and then 80ml containing 0.2% ammonium persulfate (mass) and 1.2% K 2 SO 4 (mass) of deionized aqueous solution is added dropwise into a three-necked flask by dropping while stirring, and the dropping speed is controlled to prevent phase separation, and the ultra-concentrated emulsion can be obtained by continuing for 20 to 30 minutes.

[0043] Transfer the ultra-concentrated emulsion into a centrifuge test tube, centrifuge at 300r / min for 2min to remove oxygen, and then pass in nitrogen gas to seal for 15min. Then, put the mixture into a dry mold, seal it and place it in a water bath at 60°C for 36 hours, then use excess deionized water and methanol t...

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Abstract

The invention discloses a porous integral medium and a preparation method and application thereof. The invention provides the porous integral medium with a nanometer line cage construction, wherein the porous integral medium consists of a nanometer line network framework and micron-order through holes, the size of the network framework is between 50 and 500nm, and the aperture of each micron-order through hole is between 1 and 100mu m. The porosity of the porous integral medium is between 60 and 95 percent. The porous integral medium which has the very regular nanometer line network framework and internal pores arranged orderly has excellent properties of high porosity, larger specific surface area, controllable aperture size, etc. The excellent properties enable the medium to be characterized by low resistance, high efficiency, high flux, etc. while the characteristics of excellent biocompatibility, wide pH accommodation range, etc. brought by the draw material enlarge the application range of the medium.

Description

technical field [0001] The invention relates to a porous integral medium and its preparation method and application. Background technique [0002] The advent of porous separation materials has brought vitality to the unprecedented development of the fields of life, medicine, materials, environment and information science. The integral separation medium with a porous structure is a new type of chromatographic medium developed to meet the needs of fast, efficient, and high-throughput analysis of complex sample systems. As a branch of integral separation media, organic polymer monolithic media has the advantages of simple preparation and easy modification, and has been widely used in the matrix of bioreactors and the separation and purification of biomacromolecules. [0003] Although the technology has made some progress internationally, it is currently facing severe challenges. At present, most of the preparation methods of organic polymer monolithic media are solution polym...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J9/00C08F2/22B29C67/08B01J20/26B01J20/28
Inventor 姚春荷杨更亮辛培勇贾宏瑛
Owner INST OF CHEM CHINESE ACAD OF SCI
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