Hyaluronic acid modified polycaprolactone/polylactic acid three-dimensional stephanoporate compound stent and preparation
A technology of polycaprolactone and hyaluronic acid, which is applied in the direction of conjugated synthetic polymer rayon, fiber processing, filament/thread forming, etc., can solve the problems such as no similar or similar patent reports.
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[0030] Example 1
[0031] Using chloroform as a co-solvent, polymer PCL with a molecular weight of 50,000 and a melting point of 58-60℃, and a polymer PLA with an average molecular weight of 100,000 and a melting point of 150-170℃ are dissolved in a ratio of 60:40 Stir evenly in a co-solvent to make a transparent and uniform solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, remove the residual solvent, take it out, layer it, and fill it in a mold with a specific shape. The temperature of the vacuum oven is set to 63°C, the mold is placed in the vacuum oven at a constant temperature for 20 minutes, and then taken out. After cooling, the mold is demolded, and then subjected to plasma modification, then soaked in a hyaluronic acid solution, and then freeze-dried to obtain Tissue engineering scaffold material with specific shape and good performance. The diameter of the fiber felt measured by scanning electron microscope and Photoshop software is 2000±30...
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[0032] Example 2
[0033]Using a mixed solvent of chloroform and DMF as a co-solvent, the polymer PCL with a molecular weight of 100,000 and a melting point of 58-60°C, and a polymer PLA with an average molecular weight of 10,000 and a melting point of 150-170°C at 40:60 Dissolve it in a co-solvent, stir it evenly, make a transparent solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, take it out, layer it and fill it in a mold with a specific shape, put it in a vacuum oven The temperature is set to 63°C, the mold is placed in a vacuum oven at a constant temperature for 35 minutes and then taken out. After cooling, it is demolded, and then subjected to plasma modification, and then immersed in a hyaluronic acid solution, and then freeze-dried to obtain a specific Tissue engineering scaffold material with shape and good performance. The diameter of the fiber felt measured by scanning electron microscope and Photoshop software is 2000±300nm. The contact ...
Example Embodiment
[0034] Example 3
[0035] Using a mixed solvent of tetrahydrofuran and acetone as a co-solvent, polymer PCL with a molecular weight of 100,000 and a melting point of 58-60°C and a polymer PLA with a molecular weight of 10,000 and a melting point of 150-170°C in a ratio of 80:20 Dissolve in a co-solvent, stir evenly, make a transparent solution, electrospun to make an electrospun fiber mat, dry it in a vacuum oven, remove the residual solvent, take it out, layer it, and fill it in a mold with a specific shape. The temperature of the vacuum oven is set to 60°C, the mold is placed in a vacuum oven at a constant temperature for 40 minutes and then taken out, cooled and demolded, and then subjected to plasma modification, then immersed in a hyaluronic acid solution, and then freeze-dried to obtain Tissue engineering scaffold material with specific shape and good performance. The diameter of the fiber felt measured by scanning electron microscope and Photoshop software is 3500±200nm. Th...
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