Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition

A hydroxyapatite and composite coating technology is applied in the field of surface modification of medical biological materials, which can solve the problems of single constant current or constant voltage mode, uneven distribution of chitosan, and can not solve the problem of uneven coating. , to achieve the effect of uniform distribution, tight bonding and no agglomeration

Inactive Publication Date: 2009-03-11
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, reports in the literature use a single constant current or constant voltage mode
This method cannot solve the shortcomings of the prepared coating such as inhomogeneity and uneven distribution of chitosan.

Method used

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  • Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition
  • Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition
  • Method for preparing hydroxylapatite/chitosan composite coating by pulse electrochemical deposition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Take the titanium plate as the working electrode.

[0020] (2) obtain the chitosan homogeneous solution that concentration is 1% with 2% acetic acid dissolving, get its 10ml;

[0021] (3) Get analytically pure calcium nitrate tetrahydrate 0.1416g, diammonium hydrogen phosphate 0.0792g, dissolve with ethanol and distilled water respectively, mix with (2), be configured into 200ml of calcium-phosphorus solution of pH=6.0 (adjusted with ammonia water), and The beaker is placed on a magnetic stirrer to stir, and finally a uniform electrolyte is obtained;

[0022] (4) With the uniform electrolyte in (3), the saturated calomel electrode is used as the reference electrode, the platinum sheet is used as the counter electrode, and the biomedical metal to be coated is used as the working electrode. deposition. The relevant parameters are: pulse high potential: -1.2V, pulse low potential: -2.0V, pulse width: 100s, deposition time: 25min.

[0023] The XRD collection of illus...

Embodiment 2

[0027] The diammonium hydrogen phosphate of embodiment 1 is changed into the Na of equimolar concentration 2 HPO 4 , for electrochemical deposition, other conditions remain unchanged.

Embodiment 3

[0029] The diammonium hydrogen phosphate of embodiment 1 is changed into the K of equimolar concentration 2 HPO 4 , for electrochemical deposition, other conditions remain unchanged.

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Abstract

The invention discloses a method for preparing hydroxylapatite/chitosan composite coat by electrochemical deposition. The method comprises the following steps: preparing electrolytic solution with certain concentration and pH value from calcium salt, phosphate and chitosan; carrying out electrodeposition in an electrolysis bath with a three-electrode system; using a saturated calomel electrode as a reference electrode, a platinum plate as a counter electrode, and biomedical metal to be coated as a working electrode; depositing compositions in the coat on a base material in ion mode for 25 minutes, with minus 1.2 volts of high pulsing electric potential, minus 2.0 volts of low pulsing electric potential, 100s of pulse width, and evenly dispersing the chitosan in a composite coat, so as to finally produce the evenly hybridized hydroxylapatite/chitosan composite coat.

Description

Technical field [0001] The invention relates to a method for modifying the surface of a medical biomaterial, in particular to the preparation of a biometal material surface coating suitable for repairing human bone damage. Background technique [0002] Calcium phosphate series ceramics have good biocompatibility and bioactivity, and have been successfully used clinically. Especially hydroxyapatite (HA) has attracted much attention. Coating bioactive calcium phosphate ceramics on the surface of medical metals can endow hard tissue biomaterials with good mechanical properties and suitable biological properties. been extensively studied in recent years. Existing coating methods include plasma spraying method, laser cladding method, powder slurry coating sintering method, sol-gel method, electrophoresis method, electrochemical deposition method and so on. Among them, the electrochemical deposition method has the advantages of simple equipment, good uniformity, and simple proc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/04C25D5/18A61L27/32
Inventor 鲁雄王英波翁杰汪建新冯波屈树新姜丽丽
Owner SOUTHWEST JIAOTONG UNIV
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