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Preparation method of ecdysterone cream capable of promoting wound healing

A technology of ecdysterone and wound healing, which is applied in the field of preparation of ecdysterone cream, and can solve the problems of weak effect and the like

Inactive Publication Date: 2009-04-29
吴旭 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it mainly focuses on the hemostatic effect of early wounds, and the effects of other aspects are relatively weak

Method used

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  • Preparation method of ecdysterone cream capable of promoting wound healing
  • Preparation method of ecdysterone cream capable of promoting wound healing
  • Preparation method of ecdysterone cream capable of promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The formulation includes the following components:

[0026] Oil phase: 35g of glyceryl monostearate, 130-150g of stearic acid, 70g of white petrolatum, 20ml of azone, 1g of ethylparaben.

[0027] Water phase: 560-580ml of purified water, 4g of borax, 4g of sodium lauryl sulfate, 10-20ml of triethanolamine, 160ml of glycerin, 3g of allantoin.

[0028] Pharmaceutical phase: 6.25g of ecdysterone is dissolved in 10ml of 75% ethanol to make ecdysterone solution.

[0029] The method proceeds as follows:

[0030] ①. Heat the oil phase and the water phase in a water bath to 90°C respectively, and keep them warm in the water bath;

[0031] ②. Dissolve 6.25g of ecdysterone in 10ml of 75% ethanol to make a drug phase;

[0032] ③, in the high shear emulsifier at 2000-6000r.min -1 Under stirring at a certain speed, the oil phase dissolved in the water bath is added to the water phase;

[0033] ④. After stirring for 3-10 minutes, wait until it is completely emulsified, remove fr...

Embodiment 2

[0038] The formulation includes the following components:

[0039] Oil phase: 35g of glyceryl monostearate, 130-150g of stearic acid, 70g of white petrolatum, 20ml of azone, 1g of ethylparaben.

[0040] Water phase: 560-580ml of purified water, 4g of borax, 4g of sodium lauryl sulfate, 10-20ml of triethanolamine, 160ml of glycerin, 3g of allantoin.

[0041] Pharmaceutical phase: 12.5g of ecdysterone is dissolved in 10ml of 75% ethanol to make ecdysterone solution.

[0042] The method proceeds as follows:

[0043] ①. Heat the oil phase and the water phase in a water bath to 90°C respectively, and keep them warm in the water bath;

[0044] ②. Dissolve 12.5g of ecdysterone in 10ml of 75% ethanol to make a drug phase;

[0045] ③, in the high shear emulsifier at 2000-6000r.min -1 Under stirring at a certain speed, the oil phase dissolved in the water bath is added to the water phase;

[0046] ④. After stirring for 3-10 minutes, wait until it is completely emulsified, remove fr...

Embodiment 3

[0051] The formulation includes the following components:

[0052] Oil phase: 35g of glyceryl monostearate, 130-150g of stearic acid, 70g of white petrolatum, 20ml of azone, 1g of ethylparaben.

[0053] Water phase: 560-580ml of purified water, 4g of borax, 4g of sodium lauryl sulfate, 10-20ml of triethanolamine, 160ml of glycerin, 3g of allantoin.

[0054] Pharmaceutical phase: 25g of ecdysterone is dissolved in 10ml of 75% ethanol to make ecdysterone solution.

[0055] The method proceeds as follows:

[0056] ①. Heat the oil phase and the water phase in a water bath to 90°C respectively, and keep them warm in the water bath;

[0057] ②. Dissolve 25g of ecdysterone in 10ml of 75% ethanol to make a drug phase;

[0058] ③, in the high shear emulsifier at 2000-6000r.min -1 Under stirring at a certain speed, the oil phase dissolved in the water bath is added to the water phase;

[0059] ④. After stirring for 3-10 minutes, wait until it is completely emulsified, remove from the...

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Abstract

The invention provides a preparation method of a cream preparation which can quicken wound healing. The components of the cream preparation comprise: glycerol monostearate, stearic acid, white Vaseline, azone, ethylparaben, purified water, borax, lauryl sodium sulfate, triethanolamine, glycerin, allantoin, ecdysterone and ethanol, wherein, the primary active ingredient is the ecdysterone which can significantly promote the proliferation of endothelial cells, epithelial cells and fibroblasts, and the mechanism thereof is that the ecdysterone can promote the synthesis of proteins and trigger the synthesis of DNA of cells. The cream preparation has the advantages of no anaphylaxis, no irritation, easy absorption, obvious therapeutic effect, low price, convenient carrying and the like. In addition, experiments validates that the cream preparation does have the efficiency of healing wounds. The cream preparation is similar to Yunnan white drug powder and also varies from the Yunnan white drug powder in the therapeutic effect.

Description

1. Technical field [0001] The invention relates to the research and development of new uses and new dosage forms of medicines, in particular to the research on the effect of ecdysterone on promoting wound healing, the preparation method, dose-effect analysis and curative effect observation of ecdysterone cream. 2. Background technology [0002] Ecdysterone (B-ecdysone) belongs to insect growth and metabolism regulation hormone, and this compound can be extracted from plants such as Cynotis arachnoidea C.B.Clarke of Commelinaceae. It is also the main extraction route of medicinal ecdysterone at present. [0003] Ecdysterone can be used for: (1) skin regeneration; (2) cosmetics; (3) anti-diabetes; (4) treatment of asthma; (5) treatment of dementia and other cerebral ischemic diseases; (6) improvement of brain dysfunction memory damage. [0004] The pharmacological mechanisms of ecdysterone include: (1) protein assimilation; (2) antioxidant effect; (3) adaptogen effect. [0...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K9/06A61P17/02A61P43/00
Inventor 吴旭郑高云张军花
Owner 吴旭
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