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Beta-TCP porous material and preparation method thereof

A porous material and slurry technology, applied in the field of β-TCP porous material and its preparation, can solve the problems of reducing the degradation performance of β-TCP material, bioglass cannot be completely degraded, and the strength will not be greatly improved, achieving superiority Degradability and mechanical properties, improvement of bone defect repair and reconstruction materials, the effect of improving mechanical properties and degradation properties

Inactive Publication Date: 2009-10-21
CENT SOUTH UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

This method alleviates the contradiction between the strength and activity of β-TCP porous materials to a certain extent, but it does not solve the problem fundamentally. One is because 5-20wt% bioglass cannot be completely degraded, which reduces the β-TCP The degradation performance of the material; the second is because the porous β-TCP material requires a certain porosity to meet its degradation ability, so that its strength will not be greatly improved

Method used

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  • Beta-TCP porous material and preparation method thereof
  • Beta-TCP porous material and preparation method thereof
  • Beta-TCP porous material and preparation method thereof

Examples

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Embodiment 1

[0040] according tofigure 1 The wet chemical preparation of Zn-doped β-TCP porous material was carried out. Dissolve ammonium phosphate, zinc nitrate, and calcium nitrate in the dissolving tank completely and fully with deionized water respectively. The solution should be clear and transparent. The corresponding stoichiometric ingredients. Inject the ammonium phosphate solution into the reaction kettle, slowly drop the calcium nitrate and zinc nitrate solutions into the ammonium phosphate solution under room temperature and stirring conditions, at the same time, slowly drip ammonia water into the reaction kettle, and continue stirring for 4 hours after the reaction is complete. Aging for 24h. The aged sol was white, and the supernatant liquid was removed, and an equal amount of deionized water was added under stirring conditions, and after repeated washing for 3 times, it was filtered through a filter funnel with a filter cloth to obtain a Zn-doped β-TCP precursor. The Zn-do...

Embodiment 2

[0042] Dissolve ammonium phosphate, zinc nitrate, and calcium nitrate in the dissolving tank completely and fully with deionized water respectively. The solution should be clear and transparent. The corresponding stoichiometric ingredients. Inject the ammonium phosphate solution into the reaction kettle, slowly drop the calcium nitrate and zinc nitrate solutions into the ammonium phosphate solution under room temperature and stirring conditions, at the same time, slowly drip ammonia water into the reaction kettle, and continue stirring for 8 hours after the reaction is complete. Aging 48h. The aged sol was white, and the supernatant liquid was removed, and an equal amount of deionized water was added under the condition of stirring. After repeated washing for 4 times, the sol was filtered through a filter funnel and a filter cloth to obtain a Zn-doped β-TCP precursor. The Zn-doped β-TCP precursor was dried under vacuum at 90°C to remove moisture. The agglomerated powder is d...

Embodiment 3

[0044] Dissolve ammonium phosphate, zinc nitrate, and calcium nitrate in the dissolving tank completely and fully with deionized water respectively. The corresponding stoichiometric ingredients. Inject the ammonium phosphate solution into the reaction kettle, slowly drop the calcium nitrate and zinc nitrate solutions into the ammonium phosphate solution under room temperature and stirring conditions, at the same time, slowly drip ammonia water into the reaction kettle, and continue stirring for 10 hours after the reaction is complete. After aging for 36 hours, remove the supernatant, add an equal amount of deionized water, wash repeatedly for 5 times, and then filter through a filter bucket with a filter cloth to obtain a Zn-doped β-TCP precursor. The Zn-doped β-TCP precursor was dried under vacuum at 80°C to remove moisture. The agglomerated powder is dry-milled and crushed in the crusher, and then passed through a 100-mesh sieve, and the sieved material is returned to conti...

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Abstract

The invention relates to a Beta-TCP porous material and a preparation method thereof. Natural plant fiber or polyurethane sponge is used as a pore creating material. A three-dimensional-net-shaped skeleton green body is prepared by immersing the pore creating material into a slurry made from Beta-TCP which is doped with a trace element Zn. The Beta-TCP porous material is obtained by drying and sintering the three-dimensional-net-shaped skeleton green body. The Beta-TCP material which is doped with the Zn better satisfies the need for material degradation and osseous tissue creeping growth. In the invention, the addition of the trace element Zn into the Beta-TCP porous material improves the ALP activity and promotes the degrading of the Beta-TCP porous material in the case of low porosity, thereby greatly improving the pressive strength and the degrading capability of the Beta-TCP porous material and solving the problem that the mechanical property and the biodegradation property of a Beta-TCP porous biological ceramics embedded material are not matched. The Beta-TCP porous material has good degradation property and good mechanical property, is expectable to improve the defects of bone defect repairing and rebuilding materials, and can be widely and clinically used.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a β-TCP porous material and a preparation method thereof. Background technique [0002] Bioactive ceramic materials are mainly composed of calcium and phosphorus elements, showing good biocompatibility, and have a certain degree of osteogenic guidance and can effectively promote the adhesion, migration, proliferation and matrix secretion of osteoblasts. Calcium phosphate bioceramics has been paid attention to in bone repair. In addition to the calcium component, it also lies in the status of phosphorus in life chemistry. Inorganic phosphate is directly involved in the life process through biological activation in living cells, which is unmatched by other acid radicals. . [0003] At present, the calcium-phosphorus system ceramic materials mainly include hydroxyapatite (HA), α-calcium phosphate (α-TCP), β-calcium phosphate (β-TCP), etc., and hydroxyapatite starts to dissolve a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B38/00A61L27/10A61L27/56
Inventor 邹俭鹏
Owner CENT SOUTH UNIV
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