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Preparation method of cohesive composite microsphere porous scaffolds

A technology of composite microspheres and porous scaffolds, which is applied in the fields of microsphere preparation, microcapsule preparation, medical science, etc., can solve the problems of difficult popularization and high technical equipment, achieve good three-dimensional connected pores, ensure mechanical strength, and facilitate the formation of scaffolds. Effect

Inactive Publication Date: 2013-05-08
CHONGQING UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it requires high technical equipment and is not easy to promote and use

Method used

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  • Preparation method of cohesive composite microsphere porous scaffolds
  • Preparation method of cohesive composite microsphere porous scaffolds
  • Preparation method of cohesive composite microsphere porous scaffolds

Examples

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Effect test

Embodiment 1

[0027] 1) Weigh 7.8001g of polylactic acid and add it to an iodine measuring bottle filled with 100ml of ethyl acetate, shake and dissolve in an ultrasonic cleaner, then add 0.3900g (mass ratio 5:100) of nano-hydroxyapatite, and continue ultrasonication Shake for 3 hours, and keep the ultrasonic water temperature not exceeding 35°C, shake the iodine bottle several times by hand; stir the ethanol aqueous solution with a mass concentration of 0.5% polyvinyl alcohol, ethanol and water ratio of 2:1 at a speed of 500r / min. , and then use a dropper to be 1cm away from the liquid surface, and add the nano-hydroxyapatite / polylactic acid / ethyl acetate mixture dropwise; after adding the liquid, filter under reduced pressure at a vacuum degree of 0.01MPa for 30min; filter the solution after refrigerated for 24h, and use Wash with deionized water for 3 times; dry in a freeze-drying oven at -10°C and a vacuum of 5.0KPa for 6 hours to obtain nano-hydroxyapatite / polylactic acid composite micr...

Embodiment 2

[0030] 1) Weigh 6.5002g of polylactic acid and add it to an iodine measuring bottle containing 100ml of ethyl acetate, shake and dissolve it in an ultrasonic cleaner, then add 0.5201g (mass ratio 8:100) of nano-hydroxyapatite, and continue ultrasonication Shake for 3 hours, keep the ultrasonic water temperature not exceeding 35°C, shake the iodine bottle several times by hand during the period; put the ethanol aqueous solution with a mass concentration of 0.8% polyvinyl alcohol, ethanol and water ratio of 5:4 at a speed of 800r / min. Stir, then add nano-hydroxyapatite / polylactic acid / ethyl acetate mixture dropwise with a dropper at a distance of 2cm from the liquid surface; after adding the liquid, filter under reduced pressure at 0.02MPa for 25 minutes; refrigerate the solution for 24 hours and then filter, Wash 3 times with deionized water; dry in a freeze-drying oven at -10°C and a vacuum of 3.0KPa for 5 hours to obtain nano-hydroxyapatite / polylactic acid composite microspher...

Embodiment 3

[0033] 1) Weigh 5.9601g of polylactic acid and add it to an iodine measuring bottle containing 100ml of ethyl acetate, shake and dissolve it in an ultrasonic cleaner, then add 0.5960g (mass ratio 10:100) of nano-hydroxyapatite, and continue ultrasonication Shake for 3 hours, keep the temperature of the ultrasonic water not exceeding 35°C, shake the iodine bottle several times by hand during the period; put the ethanol aqueous solution with a mass concentration of 1.0% polyvinyl alcohol, ethanol and water ratio of 5:3 into the magnetic field at a speed of 1000r / min Stir, then add nano-hydroxyapatite / polylactic acid / ethyl acetate mixture dropwise with a dropper at a distance of 3cm from the liquid surface; after adding the liquid, filter under reduced pressure at 0.02MPa for 20min; refrigerate the solution for 24h and then filter, Wash 3 times with deionized water, dry in a freeze-drying oven at -10°C and vacuum: 2.5KPa for 4 hours, and obtain nano-hydroxyapatite / polylactic acid ...

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Abstract

The invention discloses a preparation method of cohesive composite microsphere porous scaffolds, which comprises the steps as follows: 1) nano hydroxyapatite and polylactic acid are adopted as raw materials, and composite microspheres are obtained by ultrasonic blending, suspension balling, solvent volatilization and freeze drying; and 2) the composite microspheres are subjected to grain size screening, mold feeding, air flow smoothening, polylactic acid solution dropwise adding and cohesion, solvent volatilization by air flow, vacuum heat insulation and sintering, demoulding and washing so asto obtain the porous scaffolds. The preparation method has simple process; the porosity factor of the composite microsphere is high; the aperture of the scaffold and the porosity factor can be adjusted; the moulding of the scaffold is convenient; the shape designability is strong; other cohesive phases are not introduced; and the heating time at high temperature is short. The prepared scaffold has good three-dimensional interlocking pores, good mechanical property and biocompatibility, can meet the demands of tissue engineering scaffold materials, and has potential and wide practical value inthe field of tissue repair in bone tissue engineering.

Description

technical field [0001] The invention belongs to the tissue engineering scaffold preparation technology, specifically, a method for preparing a porous scaffold by bonding composite microspheres of nano-hydroxyapatite / polylactic acid. Background technique [0002] The final product of polylactic acid (PLA) metabolism in the human body is CO 2 and H 2 O, the intermediate product lactic acid is also a product of normal glucose metabolism in the body and will not accumulate in vital organs, so it has excellent biodegradable absorbability and has been widely used in the preparation of tissue engineering scaffolds. It is one of the most widely used biodegradable biomaterials so far one. At the same time, hydroxyapatite (HA) has a similar inorganic composition to human bone tissue, and is an ideal matrix environment for bone cells. The combination with polylactic acid can improve the mechanical properties of polylactic acid and guide osteogenesis. The rapid degradation of limesto...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/56B01J13/02A61L27/18
Inventor 徐文峰廖晓玲刘希东
Owner CHONGQING UNIV OF ARTS & SCI
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