Oxaliplatin medicament composition, preparation method thereof and method for synthesizing oxaliplatin as raw medicinal material
A technology of oxaliplatin and composition, which is applied in the field of synthesis of raw material oxaliplatin, can solve the problems of reducing product yield, operator injury, poor molding and the like
Active Publication Date: 2009-12-30
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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Abstract
The invention relates to an oxaliplatin medicament composition as an anticancer medicament, a preparation method thereof and a method for synthesizing oxaliplatin as raw medicinal material. The composition comprises oxaliplatin and lactose, wherein the mass ratio of the oxaliplatin to the lactose is 1:12-1:20. The composition can be added with injection water and pH regulator and made into freeze-dried powder injection through freeze drying. The freeze-dried powder injection not only has the advantages of good formability, plump shape and the like, but also overcomes the prejudice that oxaliplatin freeze-dried powder injection taking the lactose as a freeze-drying carrier is not good in formability and the like. The synthesis method comprises: 1) taking K2PtCl4 and trans-diaminocyclohexane as raw materials to prepare an intermediate (I); 2) forming an intermediate (II) through intermediate reaction; and 3) forming the oxaliplatin through the reaction of the intermediate (II) and potassium oxalate solution, wherein the step 2) also comprises a process of adding KI for reaction. The method has the advantages of simple reaction, mild conditions, short time and no silver ions in products.
Application Domain
Powder deliveryGroup 8/9/10/18 element organic compounds +4
Technology Topic
Freeze dryLactose +12
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