Microgel based on cyclodextrins and preparation method thereof

A technology of cyclodextrin and microgel, which is applied in the direction of medical preparations of non-active ingredients, pharmaceutical formulas, non-effective ingredients of polymer compounds, etc., can solve the problem of not obvious responsiveness to external environmental stimuli and lack of responsiveness to external conditions. , not easy to degrade and other problems, to achieve the effect of controllable molecular weight, narrow molecular weight distribution and fast reaction speed

Inactive Publication Date: 2010-03-10
江苏景越塑料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its shortcoming is that the stimulus response to the external environment is not obvious
The disadvantage of hydrogels that use chemical bonds is that they are not easy to degrade
[0009] Although the abov

Method used

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  • Microgel based on cyclodextrins and preparation method thereof
  • Microgel based on cyclodextrins and preparation method thereof
  • Microgel based on cyclodextrins and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0072] In conjunction with Examples 1 to 3, describe the method for synthesizing polycationic electrolytes based on cyclodextrin

Embodiment 1

[0073] Example 1: β-CD-g-DMAEMA 30 preparation method

[0074] (1) Preparation of β-CD: Weigh a certain amount of β-cyclodextrin into an ampoule, put it into a vacuum drying oven, set the temperature at 120°C, and dry overnight. Cool immediately in a desiccator after removal.

[0075] (2) ATRP initiator chloroacetylated cyclodextrin (β-CD-Cl 21 ) preparation: put β-CD (4.5mmol, 5g) into a beaker in advance, add 30mL of N,N-dimethylformamide (DMF), and transfer it to a 100mL beaker after β-CD is completely dissolved In a three-necked round-bottomed flask equipped with a reflux condenser, dropping funnel and nitrogen conduit, pass inert gas N 2 After protection, chloroacetyl chloride (0.22 mol, 25 g) dissolved in 10 mL of DMF was slowly added dropwise to the β-CD solution under magnetic stirring. The dropwise reaction was carried out at room temperature. After the dropwise addition, the oil bath was heated to 80° C., and the system was reacted at this temperature for 24 hou...

Embodiment 2

[0082] Example 2: γ-CD-g-DMAEMA 30 preparation method

[0083] (1) Preparation of γ-cyclodextrin and ATRP initiator based on γ-cyclodextrin (γ-CD-Cl 21 ) preparation and purification: with embodiment one.

[0084] (2)γ-CD-g-DMAEMA 30 Preparation: Put the vial in an oven at 120°C to dry in advance, take it out and plug it with a ground glass stopper, and cool it with a pump until it reaches room temperature. The dry initiator γ-CD-Cl 21 (0.046mmol) and ligand 2,2'-bipyridine (2.50mmol) were added in the branch bottle, stirred evenly, and then the hydrophilic monomer methacrylate-2-(dimethylamino)ethyl (DMAEMA) ( 37.50 mmol) was added into the mixture containing the initiator and the ligand with a syringe, stirred and dissolved, vacuumized, and then high-purity argon was introduced, and repeated three times. Add 8 mL of deionized water with a syringe, vacuumize, then flush with argon, stir and dissolve until the mixture solution is transparent. Finally, purified cuprous br...

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Abstract

The invention belongs to the fields of high polymer and biological materials, which discloses a microgel based on cyclodextrins compounds and a preparation method thereof, and star cationic polyelectrolyte based on cyclodextrins (CD) and block anionic polyelectrolyte based on polyethylene glycols (PEG) can be combined to form the microgel under electrostatic effect. The invention uses natural polymer polysaccharide, such as the cyclodextrins, as raw materials for preparing the cationic electrolyte, the microgel has good biocompatibility, low price and convenience in accessibility; and based onthe electrostatic effect, the invention uses the electrostatic effect between a PDMAEMA chain segment in the synthetic cationic polyelectrolyte and a PMAA chain segment in the anionic polyelectrolyteto form a physical microgel without covalent bond crosslinking, and the preparation method is simple and easy to control.

Description

technical field [0001] The invention belongs to the fields of macromolecules and biomaterials, and in particular relates to a cyclodextrin-based microgel and a preparation method thereof. Background technique [0002] Hydrogels can be defined as cross-linked polymers capable of swelling in water and retaining large amounts of water without dissolving. Its synthesis can be traced back to the late 1950s, when Wichterle and Lim synthesized the first polyhydroxyethylmethacrylate (PHEMA) hydrogel for medical use. Due to the good hydrophilicity and biocompatibility of hydrogels, in the field of biomedicine, hydrogels can be used as burn coatings, drug delivery systems, dental materials, immobilized carriers of biomolecules and cells, etc. There are various classification methods for hydrogels, and there are three most commonly used classification methods: (1) according to the response of hydrogels to external stimuli, they can be divided into two categories: traditional hydrogels...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08L5/16C08F293/00C08B37/16A61K47/40A61K47/34A61K47/10
Inventor 倪沛红吴要娟张明祖朱秀林
Owner 江苏景越塑料科技有限公司
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