Human genetic engineering antibody TRD 109 as well as preparation method and application thereof

A genetically engineered antibody, antibody technology, applied in the direction of antibodies, anti-inflammatory agents, recombinant DNA technology, etc., can solve the problems of heavy economic burden, high treatment costs, low immunogenicity, etc. Simple structure and the effect of relieving symptoms of allergic rhinitis
CN101696243AInactive Publication Date: 2010-04-21INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF HYGIENE & ENVIRONMENTAL MEDICINE PLA ACAD OF MILITARY MEDICAL
Publication Date
2010-04-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a human genetic engineering antibody TRD 109 which is screened by utilizing a molecular biological technology-ribosome display technology, aims to TNF-alpha and realizes high-efficiency expression of the antibody to a prokaryotic system. A biological characteristic research demonstrates that the TRD 109 is a human genetic engineering antibody which has high affinity, better stability, simple structure and easy construction and can specifically neutralize the TNF-alpha, inhibit the generation of multiple kinds of cell factors, block the generation and development of AR in the source and is a human anti TNF-alpha antibody which can reduce the infiltration of eosinophils in a mouse nasal mucous membrane and relieve mouse allergic rhinitis symptom; and a gene and a gene product of the human anti TNF-alpha antibody can be used for preparing a medicaments for diagnosing and treating diseases caused by overexpression of the TNF-alpha, such as preparing a medicament for treating diseases including allergic rhinitis and rheumatoid arthritis.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to the human genetic engineering antibody TRD109 and its preparation method and application. Background technique

[0002] Allergic rhinitis (AR) is a nasal inflammatory disease triggered by allergens and mediated by IgE. It is the most common disease in otolaryngology and one of the most common chronic diseases in the world. The main symptoms are runny nose, nasal congestion, nasal itching and sneezing. With the rapid changes in modern human life style and ecological environment, the incidence of AR is increasing globally, and the incidence in cities is much higher than that in rural areas. Although AR is not a major disease, it has a great impact on people's work, study and life. Serious impact, has gradually become a global health problem. The principle of AR treatment is mainly to avoid exposure to allergens, drug control and immune regulation. At present, there is no specific tre...

Claims

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