Pharmaceutical composition, food or beverage capable of enhancing sympathetic nerve activity
A technology of pharmaceutical composition and diet, applied in the above-mentioned pharmaceutical composition or diet field of obesity and/or its comorbidities, can solve problems such as no effect found, no effect on obesity found, etc.
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Embodiment 1
[0106] Embodiment 1:2,3-dihydro-3, the preparation of 5-dihydroxy-6-methyl-4H-pyran-4-one (from Refined from lactic acid bacteria culture supernatant)
[0107] As the culture supernatant of lactic acid bacteria, the Lactobacillus plantarum Freeze-dried product of culture supernatant obtained by culturing SAM 2446 strain (FERMABP-10438) in MRS medium. Will Lactobacillus plantarum After the SAM 2446 strain was inoculated into the sterilized MRS medium, it was cultured statically at 37°C for 1 day. Then, bacterial cells were removed by centrifugation to obtain a culture supernatant. Using the obtained culture supernatant, a freeze-dried product was prepared by a usual method as a starting material. First, the lactic acid bacteria culture supernatant was subjected to ultrafiltration using Ultrafiltration Membranes YM10 (manufactured by Millipore Corporation) to obtain low-molecular fractions that passed through the membrane. Next, using a Develosil C30UG-5 column (ma...
Embodiment 2
[0108] Example 2: Effect of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on rat kidney Evaluation of effects on visceral sympathetic activity, blood pressure, and gastric vagal (parasympathetic) activity
[0109]In the experiment, male Wistar rats with a body weight of about 300 g were used for more than one week in a constant temperature animal room at 24° C. under a light-dark cycle (lights on from 8:00 to 20:00) every 12 hours. For each neural experiment, 1 rat was used respectively. They were allowed to ingest bait (Oriental yeast, MF) and water freely. In order to study the activity of the autonomic nerves, after fasting for 3 hours on the day of the experiment, the laparotomy was performed under urethane anesthesia in the middle of the bright period, using T.Yamano et al., Neurosci.Lett.313:78-82 (2001), A.Niijima et al., Autonom.Neurosci.: Basic & Clinical97:99-102 (2002) and M.Tanida et al., Am.J.Physiol: Regulatory, Integrative and Comerative Physiology 288:...
Embodiment 3
[0111] Example 3: Effect of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on rats Sympathetic nerve activity in interscapular brown adipose tissue and sympathetic activity in white adipose tissue around epididymis Evaluation of Neural Activity Effects
[0112] Using the same method as in Example 2, using the method described in the literature disclosed in the above-mentioned Example 2, analyze the 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran- Effects of 4-one intraduodenal administration (10 μg) on the sympathetic nerve activity in the white adipose tissue around the epididymis and the sympathetic nerve activity in the brown interscapular adipose tissue. For each neural experiment, 1 rat was used respectively.
[0113] As a result, the sympathetic activity of interscapular brown adipocytes ( Figure 6 ), sympathetic nerve activity in the white adipose tissue around the epididymis ( Figure 7 ) are hyperactive.
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