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Pharmaceutical composition, food or beverage capable of enhancing sympathetic nerve activity

A technology of pharmaceutical composition and diet, applied in the above-mentioned pharmaceutical composition or diet field of obesity and/or its comorbidities, can solve problems such as no effect found, no effect on obesity found, etc.

Inactive Publication Date: 2010-05-12
SUNTORY HLDG LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In particular, when focusing on the therapeutic effect of obesity by lactic acid bacteria, the obesity-suppressing effect of ginseng root fermented products using lactic acid bacteria has been disclosed (Patent Document 1), and the accumulation of visceral fat by lactic acid bacteria cultures has been disclosed. effects (Patent Document 2), etc., but no specific effects on white adipose tissue and brown adipose tissue have been found
In addition, when focusing on the improvement of health function using the autonomic nerve regulation effect of lactic acid bacteria, only the improvement effect of laxative was found (Patent Document 3), and no effect on obesity was found

Method used

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  • Pharmaceutical composition, food or beverage capable of enhancing sympathetic nerve activity
  • Pharmaceutical composition, food or beverage capable of enhancing sympathetic nerve activity
  • Pharmaceutical composition, food or beverage capable of enhancing sympathetic nerve activity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0106] Embodiment 1:2,3-dihydro-3, the preparation of 5-dihydroxy-6-methyl-4H-pyran-4-one (from Refined from lactic acid bacteria culture supernatant)

[0107] As the culture supernatant of lactic acid bacteria, the Lactobacillus plantarum Freeze-dried product of culture supernatant obtained by culturing SAM 2446 strain (FERMABP-10438) in MRS medium. Will Lactobacillus plantarum After the SAM 2446 strain was inoculated into the sterilized MRS medium, it was cultured statically at 37°C for 1 day. Then, bacterial cells were removed by centrifugation to obtain a culture supernatant. Using the obtained culture supernatant, a freeze-dried product was prepared by a usual method as a starting material. First, the lactic acid bacteria culture supernatant was subjected to ultrafiltration using Ultrafiltration Membranes YM10 (manufactured by Millipore Corporation) to obtain low-molecular fractions that passed through the membrane. Next, using a Develosil C30UG-5 column (ma...

Embodiment 2

[0108] Example 2: Effect of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on rat kidney Evaluation of effects on visceral sympathetic activity, blood pressure, and gastric vagal (parasympathetic) activity

[0109]In the experiment, male Wistar rats with a body weight of about 300 g were used for more than one week in a constant temperature animal room at 24° C. under a light-dark cycle (lights on from 8:00 to 20:00) every 12 hours. For each neural experiment, 1 rat was used respectively. They were allowed to ingest bait (Oriental yeast, MF) and water freely. In order to study the activity of the autonomic nerves, after fasting for 3 hours on the day of the experiment, the laparotomy was performed under urethane anesthesia in the middle of the bright period, using T.Yamano et al., Neurosci.Lett.313:78-82 (2001), A.Niijima et al., Autonom.Neurosci.: Basic & Clinical97:99-102 (2002) and M.Tanida et al., Am.J.Physiol: Regulatory, Integrative and Comerative Physiology 288:...

Embodiment 3

[0111] Example 3: Effect of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one on rats Sympathetic nerve activity in interscapular brown adipose tissue and sympathetic activity in white adipose tissue around epididymis Evaluation of Neural Activity Effects

[0112] Using the same method as in Example 2, using the method described in the literature disclosed in the above-mentioned Example 2, analyze the 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran- Effects of 4-one intraduodenal administration (10 μg) on ​​the sympathetic nerve activity in the white adipose tissue around the epididymis and the sympathetic nerve activity in the brown interscapular adipose tissue. For each neural experiment, 1 rat was used respectively.

[0113] As a result, the sympathetic activity of interscapular brown adipocytes ( Figure 6 ), sympathetic nerve activity in the white adipose tissue around the epididymis ( Figure 7 ) are hyperactive.

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Abstract

It is intended to provide a safe composition for preventing or treating obesity or related complications which has an autonomic nervous control effect, in particular, an effect of enhancing sympathetic nervous activity and an effect of promoting energy metabolism. Thus, a medicinal composition, a food or a drink containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one and having an autonomic nervous control effect and an effect of promoting energy metabolism is provided.

Description

technical field [0001] The present invention relates to a pharmaceutical composition or food containing 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, which has the function of regulating autonomic nerves. The present invention also relates to the above-mentioned pharmaceutical combination that has the effect of hyperactivity of sympathetic nerves, and further has the effect of promoting energy metabolism, and is used for treating diseases or states related to autonomic nerve activity or energy metabolism, especially obesity and / or its comorbidities food or food. Background technique [0002] In order to maintain the constancy of the organism, the organism has an autonomic nervous system, an endocrine system, and an immune system. Among them, because the autonomic nervous system works relatively independently from the control of the brain, especially unconsciously, it is given this name, mainly to regulate the functions of the internal organs. The autonomic nervous sys...

Claims

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Application Information

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IPC IPC(8): C07D309/32A23L1/30A61K31/351A61K35/74A61P1/16A61P3/04A61P3/06A61P3/10A61P9/10A61P9/12A61P11/16A61P15/08A61P19/02A61P19/06A61P19/08A61P25/02A61K35/744A61K35/745A61K35/747
CPCA61K35/745C12G3/06A23V2002/00A61K35/747A23L1/3014A61K31/351A23C9/13A61K35/744A23L1/30C07D309/32A23L2/52A23L33/10A23L33/135A61P1/16A61P3/04A61P3/06A61P3/10A61P9/10A61P9/12A61P11/16A61P15/08A61P19/02A61P19/06A61P19/08A61P25/00A61P25/02A23V2250/606A23V2250/032A23V2250/708A61K35/74
Inventor 别府佳纪鹤冈伸夫橹木智裕小村启永井克也
Owner SUNTORY HLDG LTD
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