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Absorbable magnesium alloy bracket of inorganic and organic antiseptic biocompatible composite coating and preparation method thereof

A magnesium alloy stent, biocompatibility technology, applied in coating, anodic oxidation, medical science, etc., can solve the problems of no drug-loaded coating and fast degradation speed, so as to improve the surface biocompatibility and solve the problem of degradation If the speed is too fast, the effect of improving the anti-corrosion effect

Active Publication Date: 2010-06-09
中知在线股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the stent degrades too quickly in the body and has no drug-loaded coating

Method used

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  • Absorbable magnesium alloy bracket of inorganic and organic antiseptic biocompatible composite coating and preparation method thereof
  • Absorbable magnesium alloy bracket of inorganic and organic antiseptic biocompatible composite coating and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Magnesium alloy WE42 (mass fraction: Y3.7-4.3%, RE (Nd: 2.0-2.5%, HeavyE: balance): 2.4-4.4%, Zr>0.4%, Shanxi Magnesium Industry Group) is laser engraved into a stent, Then it is placed in the mixture containing mass concentration 7% HCl, mass concentration 8% FeCl 2 Ultrasonic treatment in the pickling solution for 30 minutes, then put it in a vacuum furnace for annealing treatment, raise the temperature to 1100°C at a rate of 3°C / min, keep it for 30 minutes, and then lower it to 20°C at a rate of 4°C / min ℃, and then ultrasonically cleaned with a power of 500W in deionized water for 15 minutes and then dried. The magnesium alloy organic-inorganic composite coating on the surface of the cell experiment has good biocompatibility, and the degradation products are non-toxic.

[0027] An inorganic anti-corrosion coating was prepared on the dried magnesium alloy stent. The micro-arc oxidation method is adopted, and the electrolyte composition is NaOH1-100g / L, NaOH 2 SiO 3...

Embodiment 2

[0033] The experimental conditions and operation process are the same as in Example 1. In the process of preparing the micro-arc oxidation inorganic coating, the oxidation time is changed to 20-120min, and the oxidation current is changed to 0.01A, 0.05A, 0.1A, 0.2A, 0.4A , 0.6A, 0.8A, 1.0A, 1.2A, 1.4A, 1.6A, 2.0A, magnesium alloy organic-inorganic composite coating on the surface of cell experiments has good biocompatibility, and the degradation products are non-toxic.

[0034] The prepared stent was tested in artificial simulated body fluid at 37°C, and the results showed that the corrosion resistance of the inorganic-organic composite coated magnesium alloy stent prepared by PLLA sealing was much higher than that of the unsealed inorganic coated magnesium alloy stent The corrosion resistance of magnesium alloy can be changed by changing the current parameters. The corrosion resistance of the micro-arc oxidation current density of 0.5A is 30 times that of the magnesium alloy ...

Embodiment 3

[0036] Experimental condition and operating process are identical with embodiment 1, just change micro-arc oxidation time to be 20-120min, oxidation current density is 0.01-2.0A\cm 2 , similar to Examples 1 and 2, only changed: in the process of preparing the organic PLLA sealing coating, the molecular weight of PLLA was changed, the magnesium alloy organic-inorganic composite coating on the surface of the cell experiment had good biocompatibility, and the degradation products were non-toxic.

[0037] The prepared stents were tested in artificial simulated body fluid at 37°C. The results showed that the degradation cycles of PLLA-sealed magnesium alloys with different molecular weights were different. The polymer coatings were degraded within 150-360 days, and the metal stents were degraded within 240-420 days. .

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Abstract

The invention relates to an absorbable magnesium alloy bracket of an inorganic and organic antiseptic biocompatible composite coating and a preparation method thereof. The absorbable magnesium alloy bracket of the inorganic and organic antiseptic biocompatible composite coating comprises a magnesium alloy bracket backbone and a composite coating. The composite coating consists of an inorganic antiseptic coating, a compact organic hole sealing coating, a drug releasing coating and a drug slow release coating; the surface layer of the absorbable magnesium alloy bracket backbone is an inorganic porous antiseptic coating, the compact organic hole sealing coating is arranged outside the inorganic antiseptic coating, the drug releasing coating is arranged outside the compact organic coating, and the drug slow release coating is arranged outside the drug releasing coating. The invention effectively improves the corrosion resistance of the magnesium alloy bracket backbone and controls releasing rate of magnesium ions; meanwhile, the organic membrane layer improves the surface biocompatibility; the degraded products have no side effect, can be absorbed by human bodies, and have good biocompatibility and blood compatibility; and the drug releasing coating can reduce burst release of drug and ensure sustained slow release of drug.

Description

technical field [0001] The invention relates to a surface modification technology of a magnesium alloy stent, in particular to an absorbable magnesium alloy stent with an inorganic organic anti-corrosion biocompatible composite coating and a preparation method thereof. Background technique [0002] In 1964, Dotter et al. proposed the concept of percutaneous transluminal angioplasty, and planned to use silicone rubber or plastic to support blood vessels to keep the blood flow in the blood vessels unobstructed. In 1969, they used metal rings as vascular stents in animals for the first time. Sigwart successfully implemented the first coronary stent in 1987. Afterwards, cardiovascular stents were widely accepted as the second milestone in the history of interventional therapy for coronary heart disease. By the beginning of the 21st century, the clinical application of drug-eluting stents represented by Cypher and TAXUS was hailed as the third milestone. [0003] Intracoronary ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/08A61L31/02A61L31/16A61L31/14C25D11/30
Inventor 许鑫华逯平
Owner 中知在线股份有限公司
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