Purification technology of curcumin compound

Abstract

The invention discloses a purification technology of a curcumin compound. Turmeric medicine serves as a raw material to be smashed and extracted by petroleum ether in a backflow mode; residue is subjected to ultrasound assistant extraction after warm immersing by sodium salicylate alcoholic solution; macroporous resin is added into extract to be separated and purified; mixture is eluted by acetone-2% glacial acetic acid (50:50); curcumin, demethoxy curcumin and bisdemethoxy curcumin fraction are respectively collected; reagent is recovered and is respectively dissolved by a small quantity of acetone; water of which the amount is three times of acetone is quickly added to be decentralized; and supernate is removed, and the mixture is precipitated, frozen and dried to obtain the product.

Description

technical field [0001] The invention relates to a purification process of curcuminoid compounds, in particular to a process for extracting sodium salicylate alcohol solution, separating and purifying macroporous resins, and simultaneously preparing three main monomeric components of curcuminoid compounds. Background technique [0002] Turmeric is the rhizome of turmeric (Curcumalonga L.), a plant in the ginger family. The main chemical components of turmeric are curcuminoids and volatile oils. In addition, it also contains sugars, sterols and trace elements. Among them, curcuminoids are the main yellow pigments and active ingredients, mainly including curcumin, demethoxycurcumin and demethoxycurcumin, all of which are acidic phenolic substances. The content of curcumin compounds in the rhizome is 3%-6%, including 70% curcumin, 10%-20% demethoxy curcumin and 10% demethoxy curcumin. [0003] Curcumin is orange-yellow needle crystal, melting point 183°C, molecular formula: C ...

AI Technical Summary

Problems solved by technology

Chinese patent CN101585757A discloses "a preparation method of curcumin, demethoxycurcumin and bisdemethoxycurcumin". Continuous countercurrent extraction with alcohol-acid aqueous solution, concentrated and placed on top for gradient elution, obtained The three monomer components are crystallized, but it has been reported that only curcumin is needle-like crystallization, and demethoxycurcumin and bisdemethoxycurcumin are not easy to crystallize. This aspect needs to be confirmed by further experiments. Large dosage, high cost, low extraction rate

Chinese patent CN1566215A proposes a "new process for extracting edible curcumin", which uses alkali extraction and acid precipitation. The reaction conditions of this method are severe and difficult to effectively control, and it is easy to cause the destruction of some pigments.

Chinese patent CN101259247A discloses a supercritical carbon dioxide extraction continuous depressurization analysis process. This method has high professional requirements and is not suitable for industrial production.

Hu Zhongze published the document "Study on the Optimum Technology of Extracting Curcumin by Ultrasonic Method". This document uses alkaline water ultrasonic extraction, which is low in cost, but the extraction rate is low.

"Extraction and Separation of Curcuminoids in Turmeric" published by Zhang Zhiyuan. This document uses ethanol ultrasonic extraction and rapid adsorption column chromatography separation. This method has a low extraction rate and is only suitable for a small amount of extraction and separation. It is not suitable for industrial production.

Wang Xianchun published "Research on the new process of extracting curcumin". This document uses neutral water extraction and enzymatic hydrolysis to remove impurities. The requirements for enzymatic hydrolysis are high and it is not suitable for industrial use.

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