Degradable airway stent and application thereof

A tracheal stent and airway technology, which is applied in the field of degradable airway stents, achieves the effects of fast degradation, little tissue irritation and strong anti-infection ability

Inactive Publication Date: 2010-07-28
GUANGDONG GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the preparatio

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] ①Preparation of magnesium alloy pipes: Die-casting process is adopted, which is similar to that of other alloys. The preparation formula is Mg:Al:Ce:Y=97:1:1:1 magnesium alloy pipes, and the outer diameter of the pipes is 2.5mm , The tube wall thickness is 0.3mm. The tensile strength was measured by a mechanical testing machine, which was 250MPa.

[0025] ②Precise engraving: Design and draw the required engraved pattern of the airway stent and import the pattern into the laser engraving machine; under nitrogen protection, the magnesium alloy pipe is precisely engraved by the laser engraving machine and the precision engraved airway stent.

[0026] ③Surface treatment: The above-mentioned airway inner stent that has been precisely carved and formed was washed with ultrasonic vibration for 5 minutes, and dried.

[0027] ④ Vacuum-dried and sealed at 4°C after disinfection for later use.

Embodiment 2

[0029] ① Preparation of magnesium alloy pipe: same as step ① in Example 1.

[0030] ②Precise engraving and forming: the same as step ② in Example 1.

[0031] ③Surface treatment: Same as step ③ in Example 1, dip-coat the sodium alginate solution wrapped with paclitaxel anticancer drug on the inner and outer surfaces of the stent, and repeat the dip-coating four times. The preparation of the sodium alginate solution encapsulating the paclitaxel anticancer drug refers to the national invention patent specification of the paclitaxel-sodium alginate microsphere vascular embolization agent and its preparation dated September 16, 2004, the patent number is ZL200410074464.3 Example 1.

[0032] ④ Vacuum-dried and sealed at 4°C after disinfection for later use.

Embodiment 3

[0034] ①Preparation of magnesium alloy pipe: adopt powder metallurgy process and foaming process, use magnesium powder and magnesium carbonate as raw materials, and use powder metallurgy method to prepare porous foam with connected pores with a pore size of 100-200 μm and a porosity of 20-40% Magnesium alloy, the preparation formula is the magnesium alloy foam block of Mg:Al:Ce:Y=97:1:1:1. A porous foamed magnesium alloy whose tensile strength is 150 MPa and whose elongation at break is at least greater than 15% as measured by a mechanical testing machine.

[0035] ②Precise engraving: Design and draw the required engraved pattern of the airway stent and import the pattern into the laser engraving machine; under the protection of nitrogen gas, the magnesium alloy foam block is precisely engraved by the laser engraving machine to obtain a Precisely carved airway inner stent, the outer diameter of the tube is 2.5mm, and the thickness of the tube wall is 0.3mm.

[0036] ③Surface ...

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Abstract

The invention discloses a degradable airway stent and application thereof. The degradable airway stent contains 80 percent to 99.5 percent of magnesium element in percentage by weight and at least one of aluminium element, manganese element, zinc element, zirconium element, rare earth element, lithium element, calcium element or silver element. The degradable airway stent can be quickly degraded, thus meeting the requirement of the airway on the degradation rate of the stent, and moreover, because the magnesium alloy stent has excellent biocompatibility, the degradable airway stent has less irritation on tissues and high anti-infection capability. Because the surface of the magnesium alloy stent is processed or coated with degradable material and therapeutic medicine, fibrous tissues cannot grow inwards to form granulation tissues, or tumor cells can be prevented from proliferating to block the airway. In addition, the magnesium alloy stent is porously processed, so that the degradation rate of the magnesium alloy stent can be increased. Consequently, the degradable airway stent can be widely applied in airways.

Description

technical field [0001] The invention belongs to the field of implanted medical devices, in particular to a degradable airway stent and its application. Background technique [0002] Tracheal stents have become an essential medical device in the treatment of airway obstruction. Large airway organic stenosis (external pressure, ring airway wall and intraluminal type) caused by various benign and malignant lesions can theoretically be treated by placing airway stents, which not only improves the quality of life of patients but also improves the quality of life of patients. Further treatment of the morbidity gains time. Existing airway stents mainly fall into three categories: silicone stents, metal mesh stents and hybrid stents. In many clinical cases, the placement of stents is temporary. With the treatment of the primary lesion, the airway stenosis will be relieved, and the stent will become loose and displaced, so the stent needs to be recovered. Many scholars believe tha...

Claims

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Application Information

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IPC IPC(8): A61L31/02A61L31/16A61L31/14A61F2/82
Inventor 陈正贤吴岳恒方年新李静
Owner GUANGDONG GENERAL HOSPITAL
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