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Porous calcium phosphate microsphere with medicinal controlled release function, preparation method and application thereof

A technology for controlled release of porous calcium phosphate and drugs, applied in the field of porous calcium phosphate microspheres and preparation, can solve the problems of inability to achieve filling, bone cement plasticity and fluidity limitation, etc. The effect of good liquidity

Inactive Publication Date: 2010-08-18
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the calcium phosphate powder used is composed of irregular particle accumulation, the plasticity and fluidity of the bone cement are limited, and it is impossible to completely fill the irregular bone defect.

Method used

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  • Porous calcium phosphate microsphere with medicinal controlled release function, preparation method and application thereof
  • Porous calcium phosphate microsphere with medicinal controlled release function, preparation method and application thereof
  • Porous calcium phosphate microsphere with medicinal controlled release function, preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1: composition is 10Li 2 O-10CaO-80B 2 o 3 (wt%) preparation of porous calcium phosphate microspheres.

[0021] The composition of 10Li was prepared by high temperature melting method 2 O-10CaO-80B 2 o 3 (wt%) borate glass, the glass is crushed and sieved to obtain glass particles between 97 μm and 154 μm. After repeated spheroidization of glass particles by flame spraying method, the obtained borate glass microspheres were collected.

[0022] Prepare K with a concentration of 0.1mol / L 2 HPO 4 The solution is used as a reaction soaking solution, and the pH value of the solution is adjusted to be greater than 9.0 by a pH meter. Soak 1 g of the borate glass microspheres obtained above in 100 mL of K 2 HPO 4 solution, put it in a constant temperature box at 37°C, soak it for 7 days, and then take it out. Remove the soaking solution, rinse with deionized water three times, and dry in an oven at 90°C for 24 hours. The dried microspheres were calcined a...

Embodiment 2

[0023] Embodiment 2: composition is 7.5Li 2 O-40CaO-52.5B 2 o 3 (wt%) preparation of porous calcium phosphate microspheres.

[0024] The composition is 7.5Li prepared by high temperature melting method 2 O-40CaO-52.5B 2 o 3 (wt%) borate glass, the glass is crushed and sieved to obtain glass particles between 97 μm and 154 μm. After repeated spheroidization of glass particles by flame spraying method, the obtained borate glass microspheres were collected.

[0025] Prepare K with a concentration of 0.25mol / L 2 HPO 4 The solution is used as a reaction soaking solution, and the pH value of the solution is adjusted to be greater than 9.0 by a pH meter. Soak 1 g of the borate glass microspheres obtained above in 100 mL of K 2 HPO 4 solution, put it in a constant temperature box at 60°C, take it out after soaking for 7 days. Remove the soaking solution, rinse three times with deionized water, and dry in an oven at 90°C for 24 hours. The dried microspheres were calcined at...

Embodiment 3

[0026] Embodiment 3: rifampicin medicine is composed of 10Li 2 O-10CaO-80B 2 o 3 (wt%) loading and release in porous calcium phosphate microspheres.

[0027] Loading rifampicin into porous calcium phosphate microspheres by pressure osmosis. Weigh 50 mg of porous microspheres, put into a clean weighing bottle (or small test tube), and pour 10 ml of saturated rifampicin solution. Put it into a vacuum drying oven and keep the vacuum degree <0.085MPa to eliminate the gas in the pores of the microspheres, and make the drug rifampicin diffuse into the pores inside the microspheres through the mechanism of concentration diffusion under the action of pressure. The sample was taken out after 5 min.

[0028] Drug release: Pour 50 mL of PBS solution (0.01 mol / L, pH=7.4) into a plastic bottle, and add the drug-loaded microspheres into the PBS solution. Put the plastic bottle into a constant temperature water bath at 37°C, and slowly release the drug while maintaining vibration. When...

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Abstract

The invention belongs to the field of biological medical materials, in particular relates to a porous calcium phosphate microsphere with a medicinal controlled release function, a preparation method and an application thereof. The main component of the microsphere is tricalcium phosphate, and the microsphere contains little hydroxyapatite at the same time. Mass pores exist on the surface of the microsphere and inside the microsphere, so that both load and controlled release of medicament is favored, the growth of new bone tissues can be promoted, and dual efficacies of medicament treatment and bone defect repairing can be realized. The preparation method is a borateglass in-situ conversion method, and comprises the step of immersing the glass microspheres of Li2O-CaO-B2O3 in different proportions in phosphate solution to prepare the porous calcium phosphate microsphere at low temperature (less than 100 DEG C). The adopted method is simple and feasible, haw low preparation temperature, and cannot affect the appearance and performance of the microsphere in the preparing process.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a porous calcium phosphate microsphere with drug controlled release function, a preparation method and an application thereof. Background technique [0002] Osteomyelitis, bone tuberculosis, infectious bone defect and other orthopedic diseases are common and intractable diseases that seriously endanger human health, and have always been clinical problems in orthopedics. Clinical treatment often adopts surgery to remove the lesion, eliminate the sequestrum, complete drainage, systemic application of antibiotics, etc. However, due to the formation of sequestrum and sinus tracts during the development of osteomyelitis, the destruction of nutrient vessels in the medullary cavity, the blood supply of compact bone only depends on the outer periosteal vessels, and long-term use of antibiotics leading to drug resistance, etc., osteomyelitis is often difficult to treat. He...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/02A61L27/12A61L27/56
Inventor 姚爱华黄文旵王德平艾凡荣徐为
Owner TONGJI UNIV
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