BC febrifugal refreshment paste for auxiliary treatment of fever and emergent physical hypothermia and preparation thereof

A technology of physical cooling and adjuvant therapy, applied in the direction of microorganism-based methods, antipyretics, biochemical equipment and methods, etc., can solve the problem that the antipyretic Xingnao patch has no obvious antipyretic effect, and bacterial cellulose-based antipyretics have not yet been seen. Heat refreshment paste, take away skin heat and other problems, to achieve good application prospects, easy to operate, soft and light texture effect

Active Publication Date: 2010-09-29
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, after testing, it was found that the antipyretic effect of this antipyretic Xingnao patch is not obvious. The polymer gel layer contains very little free water, which cannot take away the heat of the skin through the evaporatio

Method used

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  • BC febrifugal refreshment paste for auxiliary treatment of fever and emergent physical hypothermia and preparation thereof
  • BC febrifugal refreshment paste for auxiliary treatment of fever and emergent physical hypothermia and preparation thereof
  • BC febrifugal refreshment paste for auxiliary treatment of fever and emergent physical hypothermia and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1

[0037] 1. Preparation and treatment of BC film

[0038] Acetobacter xylinum (Acetobacter xylinum) was expanded in the seed medium at 30℃ for 24 hours according to the inoculum of 2~3 inoculation loops, and then transferred to the fermentation medium at 30℃ according to the inoculum of 6%. 4, 7, 10 days, harvest the bacterial cellulose (BC) wet film; soak the prepared BC film in 1% NaOH solution in a water bath at 80°C until the BC film turns white and translucent, and then combine the prepared BC film with the commercially available BC film The heat-relieving stickers are cut into rectangles with a diameter of 2cm×4.5cm for use. The thickness of BC_4d is 1.61mm, the thickness of BC_7d is 2.78mm, the thickness of BC_10d is 3.44mm, and the thickness of commercially available heat-releasing stickers is 2.50mm;

[0039] Among them, the seed medium and the fermentation medium are both: 2.5 g of mannitol, glucose, sucrose or fructose, 0.3 g of peptone or tryptone, 0.5 g...

Example Embodiment

[0047] Example 2

[0048] 1. Preparation and treatment of BC film

[0049] Gluconacetobacter xylinus was expanded and cultured in the seed medium at 30°C for 24 hours at the inoculum of 2 to 3 loops, and then transferred to the fermentation medium at 30°C according to the inoculum of 6%. After 4, 7, and 10 days, harvest the bacterial cellulose (BC) wet film; soak the prepared BC film in a 2% NaOH solution in a water bath at 90°C until the BC film turns white and translucent, and then combine the prepared BC film with The commercially available heat-releasing paste is cut into a rectangle with a diameter of 2cm×4.5cm for later use. The thickness of BC_4d is 1.62mm, the thickness of BC_7d is 2.74mm, the thickness of BC_10d is 3.47mm, and the thickness of the commercially available heat-releasing paste is 2.50mm. ;

[0050] Among them, the seed medium and fermentation medium are both: mannitol, glucose, sucrose or fructose 10g, yeast extract 0.5g, peptone 0.5g, citric acid 0.115g, Na ...

Example Embodiment

[0058] Example 3

[0059] 1. Preparation and treatment of BC film

[0060] Gluconobacter xylinum was expanded and cultured in the seed medium at 30°C for 24 hours at the inoculum of 2 to 3 loops, and then transferred to the fermentation medium at 30°C according to the inoculum of 6%. 4, 7, 10 days, harvest the bacterial cellulose (BC) wet film; soak the prepared BC film in 0.5% NaOH solution in a water bath at 100°C until the BC film turns white and translucent, and then combine the prepared BC film with the commercially available BC film The heat-relieving paste is cut into a rectangle with a diameter of 2cm×4.5cm for later use. The thickness of BC_4d is 1.64mm, the thickness of BC_7d is 2.68mm, the thickness of BC_10d is 3.38mm, and the thickness of the commercially available heat-relieving paste is 2.50mm;

[0061] Among them, the seed medium and fermentation medium are both: 2g of mannitol, glucose, sucrose or fructose, 0.5g of yeast extract, 0.5g of peptone, 0.115g of citric ac...

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Abstract

The invention relates to a BC febrifugal refreshment paste for auxiliary treatment of fever and emergent physical hypothermia and preparation thereof. The BC febrifugal refreshment paste comprises the components: a bacterial cellulose membrane and febrifugal refreshment medicinal reagent. The preparation comprises the following steps of: performing seed culture on BC production strains at the temperature of 30 DEG C, inoculating the BC production strains to a fermentation culture medium for culture to prepare a BC wet membrane, then immersing the wet membrane into NaOH solution, and performing water bath until the BC membrane is white and semitransparent and putting the BC membrane aside for later use; and then putting the BC membrane into heat-clearing refreshment medicinal liquid to process the BC membrane for 5 to 30 minutes to prepare the febrifugal refreshment paste. The bacteria cellulose-based febrifugal refreshment paste has the advantages of high moisture content, good biocompatibility, no conglutination and stimulation to skin, safety and environmental protection; and the preparation method has the advantages of simplicity, convenience, easy operation, low cost and friendliness to environment, and has the excellent application prospect.

Description

technical field [0001] The invention belongs to the field of antipyretic xingnao plaster and its preparation in biomedical materials, and particularly relates to a BC antipyretic xingnao plaster for auxiliary treatment of fever and emergency physical cooling and its preparation. Background technique [0002] Bacterial Cellulose (BC) is a kind of natural cellulose synthesized by microorganisms. From the molecular formula, BC is no different from ordinary plant cellulose, but because of its unique physical and chemical structure, it endows it with extremely high mechanical strength and biocompatibility. The formed BC is composed of ribbon-shaped microfibers, which are highly crystalline and highly single-oriented fibers, which are intricately entangled together to form a unique three-dimensional network structure. There are many "holes" inside the unique three-dimensional network structure of BC, which has good air permeability, Water permeability, can absorb 60 to 700 times ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/61A61K31/045A61K31/085A61K36/185A61K36/233A61K36/534A61K36/54A61K31/125A61K31/11A61K31/717A61K9/70A61P29/00A61P25/00C12P19/04C12R1/01C12R1/02C12R1/41C12R1/38C12R1/025C12R1/05C12R1/065
CPCY02A50/30
Inventor 洪枫魏斌杨光
Owner DONGHUA UNIV
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