Peritoneal dialysate

Abstract

It is intended to provide a safe and highly stable peritoneal dialysate which causes neither peritoneal membrane disorders nor peritoneal sclerosis in frequently repeated peritoneal dialysis treatment, can protect the residual renal functions in chronic renal failure and inhibit the progress of renal damage over a long period of time, and enables peritoneal dialysis treatment in a diabetic patient. A peritoneal dialysate which contains 0.05 to 3.5 w / v% of taurine and 0.1 to 6.5 w / v% of trehalose as osmotic agents and having a pH value regulated to 6.5 to 7.5.

Description

technical field [0001] The present application relates to a peritoneal dialysis fluid used in peritoneal dialysis. Background technique [0002] Peritoneal dialysis is a treatment method that injects a sufficient amount of peritoneal dialysis fluid into the peritoneal cavity of patients with acute and chronic renal failure who have lost renal function and leaves it for a specified period of time, so that the waste in the body fluid is excreted into the dialysis fluid through the peritoneum . At the same time, the purpose of regulating the balance of various body fluid components through the treatment means is achieved. Typically peritoneal dialysis is performed using a solution called peritoneal dialysis fluid. [0003] One of such solutions includes, for example, a dialysate for continuous portable peritoneal dialysis (CAPD). The prior art discloses a dialysate that contains, in addition to common electrolyte components such as sodium chloride, calcium chloride, and magn...

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Problems solved by technology

[0007] In addition, at the above-mentioned neutral to slightly alkaline pH, there are also problems such as glucose decomposition, 5-hydroxymethylfurfural (5-HMF) species, formic acid, aldehydes, etc. and reduce

[0014] However, the problem of the peritoneal dialysis fluid remaining in Patent Documents 2 to 4 is that it cannot be said that it has not completely replaced the glucose-based peritoneal dialysis fluid that has been the mainstream in the past.

The peritoneal dialysis solution of Patent Document 3 uses trehalose mixed with glucose used in conventional peritoneal dialysis solutions. However, since glucose is used, there is still a problem that peritoneal damage and hyperglycemia may occur.

[0015] In addition, the peritoneal dialysis solutions of Patent Documents 2 and 4 do not contain glucose. However, when only one substance is used as an osmotic pressure substance to bear all the activity, these osmotic pressure substances must be used in a relatively high concentration.

At this time, due to frequent dialysis, the peritoneum becomes fragile, etc., when the dialysate suddenly flows into the blood, it cannot be denied that these high-concentration substances may disturb the metabolism of solids

In addition, in the case of a substance bearing all the activity, due to other unpredictable circumstances, accidental factors from the outside world or factors from the body during dialysis, the pH value changes or the reaction of the contained substance is caused, which is harmful to the dialysis patients. The possibility of danger cannot be completely denied

In general, peritoneal dialysis solutions using osmotic pressure substances other than glucose mainly have the problem that the safety of the body for long-term use cannot be fully confirmed, so it has not been used sufficiently until now.

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