Berberine tannate dispersible tablet and preparation method thereof

Abstract

The invention provides an antibacterial agent berberine tannate dispersible tablet and a preparation method thereof. The formula comprises berberine tannate as the principal agent and auxiliary additives, wherein the auxiliary additives are the additives of the common dispersible tablet preparation, and a flavoring agent is added. A full-powder direct tablet compressing method or a tablet compressing wet granulation method can be adopted, and the tablet can be a plain tablet or a film-coated tablet. Compared with other preparations, the invention has the characteristics of rapid disintegration, quick dissolving out and good disperse state. Based on the berberine tannate tablet for children, the invention provides the dispersible tablet which is prepared by changing the preparation and can be taken by children conveniently, and the dispersible tablet can rapidly disintegrate in saliva and be dissolved into a sweet liquid medicine, thus the dispersible tablet is taken by keeping in mouth and sucking, can be accepted and taken more easily by children, and has convenient use.

Description

technical field [0001] The present invention designs a kind of antibacterial drug berberine tannin (tasteless berberine) dispersible tablet and preparation method Background technique [0002] Berberine, also known as berberine, is a traditional medicine for treating enteritis and bacillary dysentery. In order to solve its bitter taste, in the early 1970s in Japan, it was made into a tannin salt with less solubility to make it lose its bitter taste, so berberine tannate is also known as "tasteless berberine". Berberine tannin Japanese Pharmacopoeia Prescription has been recorded from the sixth revised edition to the fourteenth revised edition, and its dosage form is powder and tablet. Since the 1980s, my country has successfully trial-produced berberine tannin raw materials and children's odorless berberine tablets (Drug Standards of Gansu Province, Drug Standards of Shaanxi Province, Drug Standards of Liaoning Province, and Drug Standards of Sichuan Province). It has been ...

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Problems solved by technology

[0003] Xiaoer Wuwei Berberine Tablets are mainly used to treat bacillary dysentery and enteritis. Compared with Berberine Hydrochloride Tablets, this product has no bitterness and strong astringent effect, and is more effective in treating gastrointestinal diarrhea caused by disharmony between the spleen and stomach. Therefore, the advent of children's tasteless berberine tablets has made some progress in reducing the bitterness of children's application of berberine hydrochloride tablets, but infants and young children with dysphagia and seriously ill patients still need to be crushed and then fed, so it cannot completely solve the problem. The problem of its difficulty in taking medicine, in addition the tannin of berberine is insoluble in water, causes the dissolution rate of children's tasteless berberine tablets to be low, the curative effect is poor, the bioavailability is low, and its clinical efficacy is greatly affected, resulting in the current domestic market. There are almost no varieties of the drug available

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