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Application method for cephalosporin C bacterium residue

A technology of cephalosporins and cephalosporins, applied in the field of biomedicine, to achieve the effect of reducing emissions, reducing dosage, and realizing clean production

Inactive Publication Date: 2011-01-05
石药集团中诺药业(石家庄)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome the deficiencies in the existing cephalosporin C production technology, and provide a method for applying mechanically of cephalosporin C scum, which can be used to reduce the amount of cephalosporin C in the culture medium through the circulation of cephalosporin C slag. Nitrogen source and carbon source nutrients are added to the raw materials, thereby reducing the production cost of cephalosporin C, reducing the discharge of waste fungus residue, and reducing the environmental pollution caused by the discharge of waste fungus residue

Method used

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  • Application method for cephalosporin C bacterium residue
  • Application method for cephalosporin C bacterium residue
  • Application method for cephalosporin C bacterium residue

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Gather 60m 3 Fermentation tank (equipment parameters: three layers of stirring paddles, six straight-blade turbine stirring paddles, d / D=0.1875, and the linear velocity of the tip of stirring paddles is 8-10m / s) Cephalosporin C fermentation broth is filtered through a filter cloth with an aperture of 30 The biochemical indexes of the bacterial residue filtered by the plate and frame filter press of ~40μm were tested. The test results were: total sugar 2.27g / 100g, protein content 12.8g / 100g;

[0029] Substitute substances are selected: mainly replace peanut cake flour with fungus residue, and substitute dextrin;

[0030] Determination of the replaced substance - the protein content of peanut flour: 42.5%;

[0031] Calculate the amount of mushroom residue added according to the protein content of peanut cake flour and mushroom residue and the substitution amount of peanut cake flour according to 300Kg of substitute peanut cake flour (the replacement ratio of peanut cake ...

Embodiment 2

[0040] Gather 60m 3 Fermentation tank (equipment parameters are the same as in Example 1) Cephalosporin C fermentation broth is filtered by the ultrafiltration membrane with a pore size of 50,000 molecular weight, and its biochemical index is detected. The detection result: total sugar 1.87g / 100mL, protein content 5.4g / 100mL;

[0041] Substitute substances are selected: mainly replace peanut cake flour with fungus residue, and substitute dextrin;

[0042] Determination of the replaced substance - the protein content of peanut flour: 42.5%;

[0043] Calculate the amount of mushroom residue added according to the protein content of peanut cake flour and mushroom residue and the substitution amount of peanut cake flour according to 260Kg of substitute peanut cake flour (the replacement ratio of peanut cake flour is 37.1%).

[0044]

[0045] Then according to the added amount of the fungus residue and the total sugar content of the fungus residue, calculate the amount of subs...

Embodiment 3

[0052] Gather 60m 3 Fermentation tank (equipment parameters are the same as in Example 1) the bacterial residue of the cephalosporin C fermentation broth filtered by the plate and frame filter press, dried to a moisture content of less than 9.5%, pulverized, passed through a 60-mesh sieve, and a sample was taken to detect its biochemical index, Test results: total sugar 32.6g / 100g, protein content 51.06g / 100g;

[0053] Substitute substances are selected: mainly replace peanut cake flour with fungus residue, and substitute dextrin;

[0054] Determination of the replaced substance - the protein content of peanut flour: 42.5%;

[0055] Calculate the amount of mushroom residue added according to the protein content of peanut cake flour and mushroom residue and the substitution amount of peanut cake flour according to 230Kg of substitute peanut cake flour (the replacement ratio of peanut cake flour is 32.8%).

[0056]

[0057] Then according to the added amount of the fungus r...

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Abstract

The invention relates to an application method for cephalosporin C bacterium residue, which uses the cephalosporin C bacterium residue as nutrition constituent of cephalosporin fermentation medium, and comprises the following steps: (1) collecting bacterium residue and measuring biochemical indicator thereof; (2) selecting replaced substance; (3) measuring the content of protein of the replaced substance, namely peanut cake powder; (4) determining application proportion; (5) calculating the addition of the bacterium residue; and (6) when blending the base materials of the cephalosporin fermentation medium, reducing the usage content of the peanut cake powder and artificial gum and adding the bacterium residue of calculated content according to the calculated result. The invention belongs to the technical field of biomedicine, uses the circulating application of the cephalosporin C bacterium residue to reduce the addition content of the nitrogen source peanut cake powder and carbon source artificial gum nutrition constituent raw materials, thereby reducing the production cost of the cephalosporin C and the discharge of the abandoned bacterium residue, decreasing the environmental pollution problem caused by abandoned bacterium residue, and being beneficial to realize cleaner production. And the invention has simple and convenient operation.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for applying cephalosporin C bacterial residue. Background technique [0002] Cephalosporins are the main varieties of anti-infective drugs in the world. At present, there are 65 major cephalosporin antibiotics in clinical use worldwide. The domestic consumption of this type of drug is also increasing year by year, and it is the fastest growing class of anti-infective drugs. Cephalosporin C is produced by filamentous fungi such as Cephalosporium acremonium and Streptomyces coryneformis, and its parent nucleus, 7-aminocephalosporanic acid, is the most important intermediate for the semi-synthesis of β-lactam antibiotics, so the production volume is very high. big. [0003] Antibiotic mycelium residues are referred to as antibiotic residues, which are produced by antibiotic production enterprises in the process of producing antibiotics. The same is true for cephalo...

Claims

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Application Information

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IPC IPC(8): C12P35/00
CPCY02P20/582
Inventor 戴秀君卢华安志强鲍红霞李素荣沈洪国陈尧
Owner 石药集团中诺药业(石家庄)有限公司
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