Venlafaxine hydrochloride controlled release tablets and preparation method thereof

A technology of venlafaxine hydrochloride and controlled-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as low drug load and avoid difficulty in swallowing , The effect of reducing production cost and reliable quality control
CN101953822AActive Publication Date: 2011-01-26HEFEI LIFEON PHARMA
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
HEFEI LIFEON PHARMA
Publication Date
2011-01-26

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Abstract

The invention discloses venlafaxine hydrochloride controlled release tablets and a preparation method thereof. The venlafaxine hydrochloride controlled release tablets are elementary osmotic pump (EOP) controlled release tablets which comprise single-layer tablet cores, insoluble semi-permeable membranes and medicament release holes. In the invention, the high-molecular-weight ethylene oxide, microcrystalline cellulose and sodium chloride three auxiliary materials mixed in a proper ratio form a balance system for medicament dissolution and osmotic pressure generation in a pump chamber, and tablet weight is adjusted by using detrix as a filler, so that a high-medicament-capacity osmotic pump preparation can be obtained and the stable and lasting release can be kept. The preparation effectively overcome the shortcomings that the conventional sustained-release preparation is limited in the stability and controllability of the medicament release and can generate stable and constant-speed release, and the medicament release is protected from the influences of stomach and intestine environments, so that individual difference is reduced and the medicament controlled release design aim of giving play to curing effects and reducing side effects is further fulfilled.
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Description

technical field

[0001] The invention relates to a venlafaxine hydrochloride controlled-release preparation, in particular to an oral venlafaxine hydrochloride osmotic pump controlled-release tablet and a preparation method thereof. Background technique

[0002] Venlafaxine is a 5-hydroxytryptamine (5-HT) and norepinephrine (NE) dual recovery blocker developed by Wyeth Corporation of the United States, which is clinically used for the treatment of depression and generalized anxiety disorder. Depression, as a "by-product" of the rapid development of modern economy, has affected people's lives more and more widely. Statistics show that 70% of people in our country are in a sub-health state, and patients with mental-related diseases account for about 5% to 10% of the population. Mental disorders and psychological disorders have become frequently-occurring and common diseases. The "World Health Report" issued by the World Health Organization (WHO) shows that depression has becom...

Claims

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