Venlafaxine hydrochloride controlled release tablets and preparation method thereof
A technology of venlafaxine hydrochloride and controlled-release tablets, which is applied in the directions of pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as low drug load and avoid difficulty in swallowing , The effect of reducing production cost and reliable quality control
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[0053] Example 1
[0054] (1) Tablet core prescription
[0055] Ingredients g / 1000 tablets
[0056] Venlafaxine Hydrochloride 85
[0057] Polyethylene oxide (molecular weight 5 million) 5
[0058] Microcrystalline cellulose 40
[0059] Sodium chloride 10
[0060] Dextrin 20
[0061] Povidone 5
[0062] Magnesium stearate 0.5
[0063] Theoretical weight of each core: 165.5mg
[0064] (2) Preparation method
[0065] Mix the proportions of venlafaxine hydrochloride, polyoxyethylene, microcrystalline cellulose, sodium chloride, dextrin, and povidone, add an appropriate amount of ethanol to make soft materials, granulate with a 30-mesh sieve, and dry at 40°C. 20 mesh whole grains. Add the proportion of magnesium stearate, mix well, and press the tablet with a shallow concave die to get it.
[0066] The composition ratio of the controlled release film coat is as follows:
[0067] Cellulose acetate 100g
[0068] Dimethyl phthalate 1g
[0069] Polyethylene glycol 1500 20g
[0070] Acetone 2500ml
[0071] ...
Example Embodiment
[0074] Example 2
[0075] (1) Tablet core prescription
[0076] Ingredients g / 1000 tablets
[0077] Venlafaxine Hydrochloride 85
[0078] Polyoxyethylene (molecular weight 5 million) 10
[0079] Microcrystalline cellulose 10
[0080] Sodium chloride 20
[0081] Dextrin 25
[0082] Povidone 5
[0083] Magnesium stearate 0.5
[0084] Theoretical weight of each core: 155.5mg
[0085] (2) The preparation method is the same as in Example 1.
[0086] Example 2 selects the diameter as For the shallow arc punched tablets, the weight gain of the controlled release film coating is controlled in the range of about 5%; double-sided laser drilling is used, and the aperture size is controlled in the range of about 0.3mm to 0.4mm.
Example Embodiment
[0087] Example 3
[0088] (1) Tablet core prescription
[0089] Ingredients g / 1000 tablets
[0090] Venlafaxine Hydrochloride 85
[0091] Polyethylene oxide (molecular weight 5 million) 5
[0092] Microcrystalline cellulose 35
[0093] Sodium chloride 15
[0094] Dextrin 54
[0095] Povidone 10
[0096] Magnesium stearate 1
[0097] Theoretical weight of each core: 205mg
[0098] (2) The preparation method is the same as in Example 1
[0099] Example 3 selects the diameter as For the shallow arc punched tablets, the weight gain of the controlled release film coating is controlled within the range of about 4%; single-sided laser drilling is used, and the aperture size is controlled at about 0.5mm.
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