Degradable double-layer compound ureteral stent tube

A ureteral stent tube, double-layer composite technology, applied in stents, catheters, medical science and other directions, can solve the problems of unbearable pain, delayed extubation, low molecular weight, etc., to reduce pain and burden, prevent ureteral stenosis, biological phase Good capacitive effect

Inactive Publication Date: 2011-03-23
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1) It must be removed through an invasive operation, that is, through a cystoscope. Although this type of cystoscopic operation is not a major operation, the patient will suffer terribly. What is more serious is that the removal of the tube will cause varying degrees of damage to the urinary tract injury, which can lead to infection and edema, often requiring emergency treatment
[0004] (2) Due to various reasons, many patients will forget to extubate or delay extubation. When the non-absorbable stent tube is left in the body for a long time to form urinary stones, when it cannot be removed through the cavity, open surgery has to be taken out, which undoubtedly seriously increases the risk of extubation. Patient suffering and financial burden
[0006] (4) The surface friction coefficient of the silicone rubber stent tube is high, it is difficult to intubate during the operation, and it is easy to slide after being inserted into th...

Method used

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  • Degradable double-layer compound ureteral stent tube

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Put 180 grams of ε-caprolactone monomer and 320 grams of L-lactide monomer after dehydration and purification into a 2500ml reaction flask, and then add the ε-caprolactone monomer and L-lactide monomer. A stannous octoate catalyst containing 0.01% of the total mass of the ester monomer was reacted at 150°C for 6 hours under vacuum conditions to obtain 500 g of elastic copolymer. The copolymer was dissolved in 2000 ml of acetone and precipitated with 4000 ml of ethanol. The material is dried in a vacuum dryer at 50°C for 48 hours to obtain an L-lactide / ε-caprolactone copolymer elastomer material. The molecular weight of the product was determined by gel permeation chromatography (GPC) and the weight average molecular weight was 230,000. 1 The H-spectrum measurement shows that the molar ratio of L-lactide to ε-caprolactone structural unit in the polymer is 75:25. The L-lactide / ε-caprolactone copolymer is determined by differential scanning calorimetry. Glass tran...

Embodiment 2

[0025] Example 2 Put 150 grams of ε-caprolactone monomer and 350 grams of L-lactide after dehydration and purification in a 2500 ml reaction flask, and then add the ε-caprolactone monomer and L-lactide monomer. The total mass of 0.01% stannous octoate catalyst was reacted at 150°C for 6 hours under vacuum to obtain 500 g of elastic copolymer. The copolymer was dissolved in 2000 ml of acetone and precipitated with 4000 ml of ethanol. The L-lactide / ε-caprolactone copolymer elastomer material is obtained by drying in a desiccator at 50°C for 48 hours. The molecular weight of the product is determined by Gel Permeation Chromatography (GPC). The weight average molecular weight is 455,000. 1 H-spectrum measurement shows that the molar ratio of L-lactide to ε-caprolactone structural unit in the polymer is 80:20. The L-lactide / ε-caprolactone copolymer is determined by differential scanning calorimetry. Glass transition temperature (T g ) Is 11°C. A solution blending method is used to ...

Embodiment 3

[0028] Example 3 Put 150 grams of ε-caprolactone monomer and 350 grams of L-lactide after dehydration and purification in a 2500 ml reaction flask, and then add the ε-caprolactone monomer and L-lactide monomer. The total mass of 0.01% stannous octoate catalyst was reacted at 150°C under vacuum for 5 hours to obtain 500 g of elastic copolymer. The copolymer was dissolved in 2000 ml of acetone and precipitated with 4000 ml of ethanol. The L-lactide / ε-caprolactone copolymer elastomer material is obtained by drying in a desiccator at 50°C for 48 hours. The molecular weight of the product is determined by Gel Permeation Chromatography (GPC). The weight average molecular weight is 100,000. 1 The H-spectrum measurement showed that the molar ratio of L-lactide to ε-caprolactone structural unit in the polymer was 77:23. The L-lactide / ε-caprolactone copolymer was determined by differential scanning calorimetry. Glass transition temperature (T g ) Is 7°C. A solution blending method is us...

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Abstract

The invention discloses a ureteral stent tube made of a degradable material. The stent tube is a double-layer compound tube, the inner layer is constituted by a L-lactide/epsilon-caprolactone copolymer (PLLCA) elastomer material, and the weight average molecular weight of an L-lactide/epsilon-caprolactone copolymer is 0.1-0.8 million, wherein an epsilon-caprolactone unit accounts for 15%-25% in the copolymer, an L-lactide unit accounts for 75%-85%, and a layer of poly-1,4-dioxanone (PPDO) is uniformly covered on the outer layer of the ureteral stent tube. The viscosity average molecular weight is 0.1-0.5 million. The ureteral stent tube has the advantages of being good in biocompatibility, being capable of realizing self-degradation, being capable of being degraded and excreted from a body without drawing the tube, and reducing suffering and economic burden of a patient.

Description

Technical field [0001] The invention relates to a ureteral stent tube used in urology, in particular to a ureteral stent tube that can be completely degraded in the human body, and belongs to the field of biomedical materials. Background technique [0002] The ureteral stent tube (double pigtail catheter, or DJ tube) is widely used in urological surgery, suitable for upper urinary tract surgery such as kidney stones, ureteral stones, hydronephrosis, kidney transplantation, benign tumors of the kidney and ureter, and lithotripsy In the treatment of mechanical lithotripsy and dilation of ureteral stricture, it can play an important role in draining urine and preventing ureteral stricture and adhesion blockage after being implanted in the ureter. At present, most of the D-J tubes in clinical applications are made of silicone rubber or polyurethane polymer materials that cannot be degraded in the human body. There are some insurmountable defects in clinical applications: [0003] (1) ...

Claims

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Application Information

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IPC IPC(8): A61F2/82A61F2/02A61L29/12A61L29/14A61L29/18A61L29/06A61M25/00
Inventor 陈和春王连嵩熊成东庞秀炳杨晓兵张铂蒋国华
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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