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Maixuekang enteric coated tablets and preparation method thereof

A technology of blood circulation and intestinal dissolving, which is applied in blood diseases, medical formulas, cardiovascular system diseases, etc., can solve the problem of destroying antithrombin active substances, unrealistic film-coated tablets, and affecting anticoagulant activity, etc. question

Inactive Publication Date: 2011-04-13
GUIZHOU XINBANG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent No. 200410049773.5 invention patent (title: "A film-coated tablet for promoting blood circulation and Tongmai with leech powder as the single active ingredient") discloses a patent for the preparation method of film-coated tablets using leech powder as raw material , and modern pharmacological studies have shown that we already know that hirudin is not a pure substance, but a family of polypeptide compounds with a homologous structure. At least there are at least 3 molecules in this family, and hirudin can be combined with Thrombin is tightly combined into a reversible complex in a non-covalent form, thereby preventing the hemostatic reaction catalyzed by thrombin and the platelet activation reaction induced by thrombin to achieve the purpose of anticoagulation. , the gastric juice destroys the active substance of its antithrombin, which greatly affects its anticoagulant activity, so its film-coated tablet is clinically unrealistic

Method used

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  • Maixuekang enteric coated tablets and preparation method thereof
  • Maixuekang enteric coated tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prescription: leech powder 25kg 1kg polyvinylpyrrolidone k90

[0040] 1kg crospovidone XL-10 7.5kg starch 0.4kg talcum powder

[0041] Preparation method: Take live leeches, wash the sediment, freeze at -5~-15°C, mash the tissue to homogenate, dry at low temperature below 50°C, sterilize, crush into fine powder, add the prescribed amount of crospovidone The 95% ethanol solution of XL-10, magnesium stearate, and polyvinylpyrrolidone k90 is wet granulated, dried below 50°C, added with 0.16kg of talcum powder, mixed and pressed into 100 tablets, and taken from No. Ⅱ acrylic resin ethanol solution (6%) 80ml, 20ml of III acrylic resin ethanol solution (2%), 1.6g of Tween 80, 1.6g of diethyl phthalate, 2.0g of castor oil and 2.0g of talcum powder (grinded with water) are prepared into a coating solution and coated.

Embodiment 2

[0043] Prescription: leech powder 20kg 1.5kg polyvinylpyrrolidone k90

[0044] 5kg starch 1.5kg crospovidone XL-10 0.2kg talcum powder

[0045] Preparation method: Take live leeches, wash the sediment, freeze at -5~-15°C, mash the tissue to homogenate, dry at low temperature below 50°C, sterilize, crush into fine powder, add the prescribed amount of crospovidone Wet granulation of XL-10, magnesium stearate, polyvinylpyrrolidone k90, 95% ethanol solution of methyl cellulose, drying below 50°C, adding 0.06kg magnesium stearate, mixing and pressing 80 tablets in total, taking No. Ⅱ acrylic acid Resin ethanol solution (6%) 80ml, III acrylic resin ethanol solution (2%) 20ml, Tween 80 1.6g, phthalyldiethyl ester 1.6g, castor oil 2.0g talcum powder (adding water and grinding) 2.0g is prepared into a bag Coating liquid coating can be obtained.

Embodiment 3

[0047] Prescription: leech powder 30kg 0.5kg methylcellulose 5kg starch 0.1kg talcum powder

[0048] 0.5kg crospovidone XL-10 1kg polyvinylpyrrolidone k90

[0049] Preparation method: Take living leeches, wash the sediment, freeze at -5~-15°C, mash the tissue to homogenate, dry at low temperature below 50°C, sterilize, crush into fine powder, add the prescribed amount of low-substituted hydroxypropyl Wet granulation of 95% ethanol solution of cellulose, magnesium stearate and methyl cellulose, drying below 50°C, adding 0.06kg of magnesium stearate, mixing and pressing 150 tablets in total, taking No. Ⅱ acrylic resin ethanol solution (6%) 80ml, 20ml of III acrylic resin ethanol solution (2%), 1.6g of Tween 80, 1.6g of diethyl phthalate, 2.0g of castor oil and 2.0g of talcum powder (grinded with water) are prepared into a coating solution and coated.

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Abstract

The invention relates to a preparation method of Maixuekang enteric coated tablets and belongs to technical field of medicaments. The enteric coated tablets are prepared by processing the following raw materials: living leeches, leeches, whitmania acranulaata whitman, hirudinaria manillensis, dinobdella ferox, haemadipsa japonica and haemadin. The preparation method comprises the following steps of: cleaning silt on the living leeches; freezing; preparing homogenate by using a waring blender; drying the homogenate at a low temperature; sterilizing, and crushing to obtain fine powder, wherein a binding agent is cellulosic-based derivatives or / and polyvinyl pyrrolidone, and a disintegrating agent is low-substituted hydroxy propyl cellulose or / and polyplasdone XL-10; granulating, and drying at the low temperature of below 50 DEG C; and adding an adequate amount of talcpowder, totally mixing, tabletting, and coating the tablets with enteric coatings.

Description

Technical field: [0001] The invention relates to a Maixuekang enteric-coated tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique: [0002] Today's cardiovascular disease has become the number one enemy that endangers human health. Hirudo has been a good medicine for antithrombotic, anticoagulant and blood stasis since ancient times. The main active ingredient is natural hirudin. Due to its limited source, it cannot be widely used. Since the advent of recombinant hirudin in 1986, large-scale clinical application research has begun, which can be used for anticoagulant and antithrombotic treatment of unstable angina, acute myocardial infarction, thrombosis after angioplasty, hemodialysis, extracorporeal circulation, diffuse Intravascular coagulation, etc., its effect is obviously better than that of heparin, and there is no heparin-induced thrombocytopenia, thrombosis, renal failure and other sequelae. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/62A61K9/32A61K9/36A61K47/32A61K47/36A61K47/38A61P7/02A61P9/10
Inventor 张观福
Owner GUIZHOU XINBANG PHARMACEUTICAL CO LTD