Rare earth ternary complex as well as preparation method and application thereof

A technology of ternary complexes and rare earths, which is applied in the direction of botanical equipment and methods, applications, and compounds containing elements of Group 3/13 of the periodic table. The effect of simple preparation process

Inactive Publication Date: 2011-05-18
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far there is no relevant report on the ternary complex formed by 2-pyridineformaldehyde thi...

Method used

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  • Rare earth ternary complex as well as preparation method and application thereof
  • Rare earth ternary complex as well as preparation method and application thereof
  • Rare earth ternary complex as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Preparation of ligand 2-pyridinecarbaldehyde thiosemicarbazone Schiff base

[0036] Dissolve 0.05mol of 2-pyridinecarbaldehyde in 50mL of absolute ethanol, place it in a 150mL round-bottomed flask, and slowly add 4.557g (0.05mol) of thiosemicarbazide in absolute ethanol solution dropwise under stirring. Reflux at 80°C for 4 hours. After the reaction, cool and a crystalline white solid precipitates out. Filter and wash with ethanol three times. The obtained solid is dried in a vacuum oven for 4 to 6 hours to obtain the pure product. (yield: 89%; melting point: 197.2~197.3)

[0037]

[0038] (2) Preparation of rare earth ternary complexes

[0039] Weigh 0.18g (1mmol) 2-pyridineformaldehyde thiosemicarbazone Schiff base and dissolve it in 5mL of hot absolute ethanol solution. 3 ) 3 ·6H 2 The methanol solution of O was slowly added dropwise to the above solution, stirred and refluxed for 4 hours, and then slowly added dropwise an absolute ethanol solution contain...

Embodiment 2～12

[0042] The difference between the following examples and Example 1 is that the Ln ligands and Hq ligands used in the preparation of rare earth ternary complexes are different, as long as the 8-hydroxyquinoline derivatives of the same molar number are substituted for 8- Hydroxyquinoline, see Table 1 for details. The rest of the content is the same as described in Example 1.

[0043] Figure 1-Figure 3 For the ultraviolet data that the prepared rare earth ternary complexes and their ligands of Example 1 are measured in DMF solution, it can be found that the ternary complexes of the same ligands have similar spectra from the ultraviolet spectrograms, and the ternary complexes of the complexes The spectra are distinct from those of the ligands. The Schiff base ligand has two absorption peaks at 260nm and 324nm respectively. After the complex is formed, the two absorption peaks have red-shifted. Distortion, the delocalized conjugation effect is weakened, and the CH=N double bond...

Embodiment 13

[0051] media diffusion method

[0052] (1) Principle: The antibacterial agent is continuously dissolved and diffused through agar to form different concentration gradients to show its antibacterial effect.

[0053] (2) Operation steps:

[0054] ① Preparation of antibacterial agent: Dissolve the rare earth complex in DMF, add a small amount of Tween 80 to solubilize and emulsify, and prepare a 0.005mol / L suspension concentrate, 8-hydroxyquinoline, 2-methyl-8-hydroxyquinoline, 5-sulfonic acid-8-hydroxyquinoline, 5-nitro-8-hydroxyquinoline, Ln(NO 3 ) 3 ·6H 2 O and Schiff's base were prepared into 0.005mol / L solutions respectively.

[0055] ②Preparation of antibacterial sheet: take a sterile and dry filter paper sheet (pore diameter 5mm), then wrap the filter paper sheet with double-layer newspaper and place it in a sterilizer for sterilization. After the sterilization is completed, put it in an incubator (37 ℃) after drying.

[0056] ③Inoculation of test bacteria: Dip with ...

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Abstract

The invention discloses a ternary complex formed by rare earth elements and 2-pyridine carboxaldehyde thiosemicarbazone Schiff base and 8-oxyquinoline or derivatives thereof as well as a preparation method and application of the ternary complex as an antibacterial agent. The chemical formula of the rare earth ternary complex is: Ln(L)Hq(NO3)3C2H5OH.CH3OH, Ln(L)(HqM)2(NO3)C2H5OH.CH3OH; Ln(L)(HqS)2(NO3) C2H5OH.CH3OH, wherein the Ln is a rare earth ion; the L is 2-pyridine carboxaldehyde thiosemicarbazone Schiff base; the Hq is 8-oxyquinoline; the HqM is a 8-oxyquinoline derivative connected with an electron donating group on the quinoline ring 2-position; and the HqS is a 8-oxyquinoline derivative connected with an electron withdrawing group on the quinoline ring 5-position. The rare earth ternary complex has the advantages of good chemical stability, heat stability and lipid solubility, strong antibacterial activity and little pollution.

Description

technical field [0001] The present invention relates to a class of rare earth ternary complexes and their preparation methods and applications, specifically, a kind of rare earth element and 2-pyridineformaldehyde thiosemicarbazone Schiff base and 8-hydroxyquinoline or quinoline ring The preparation method of the ternary complex formed by 8-hydroxyquinoline derivatives with substituents and its application as an antibacterial agent. Background technique [0002] The pace of mankind has entered the 21st century. With the improvement of human living standards, public health has attracted more and more attention. From the "atypical pneumonia" in the spring of 2003 to the "hand-mouth-foot" disease in 2008 and the Infections to humans such as Influenza A (H1N1) have made the public aware that health and safety issues are related to the health and safety of the country and all mankind. Make people aware of the fear of bacteria and viruses and worry about human health. [0003] R...

Claims

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Application Information

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IPC IPC(8): C07F5/00A01N55/02A01P3/00
Inventor 许东芳沈智慧何其庄
Owner SHANGHAI NORMAL UNIVERSITY
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