Osthole derivative, its preparation method and its application in preparing medicine for treating breast cancer

A technology of osthole and derivatives, which is applied in the direction of drug combination, antineoplastic drugs, and active ingredients of heterocyclic compounds, etc., which can solve the problems of human body damage, damage to hematopoietic and immune functions, and high price, and achieve fewer synthesis steps and simple reactions , the effect of high yield
CN102190645AInactive Publication Date: 2011-09-21SHANGHAI UNIV OF T C M
3 Cites 10 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI UNIV OF T C M
Publication Date
2011-09-21
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a novel osthole derivative which is a compound having a structure of formula I or formula II. The invention further discloses a preparation method of the osthole derivative comprising that the osthole derivative as an initial raw material undergoes a hydrogenation reduction reaction; a product of the hydrogenation reduction reaction is reacted with N-bromo succinimide (NBS) and then bromine is introduced into the product; and the bromination product undergoes a coupling reaction with multiple boracic acids in the presence of palladium catalysts and thus a series of osthole derivatives are obtained. The invention further discloses an application of the osthole derivative in preparing medicine for treating breast cancer, wherein the osthole derivative exhibits IC50 values of 0.2 to 50 micrometers for inhibitions of breast cancer cells MCF-7 and thus has strong inhibition effects for breast cancer cells MCF-7.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to osthole derivatives, which have inhibitory effect on MCF-7 cells, some of which have obvious inhibitory effect, and can be used to prepare lead compounds of drugs for treating breast cancer. The invention also relates to the preparation method of the osthole derivative and its application in the preparation of anti-breast cancer drugs. Background technique

[0002] Cnidium monnieri (Cnidium monnieri (L.) Cusson) is the dry and mature fruit of Cnidium monnieri (L.) Cusson in the Umbelliferae family (Umbelliferae). It grows and distributes in various regions of my country, and its natural resources are very rich. Fructus Cnidii is warm in nature, bitter in taste, returns to the kidney meridian, and has a small poison. It is used externally to remove dampness, kill parasites and relieve itching, orally, to warm the kidney and strengthen yang, to dispel wind and dry dampness. For the treatment of impotence, cold uterus, lumbago d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More