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Polyurethane material surface-modified by polyethylene glycol and derivatives thereof as well as preparation method and application thereof

A polyurethane material and polyethylene glycol technology, applied in the field of polyurethane materials, can solve the problems affecting the performance of the material body, complicated equipment, and the time required for chemical reagent methods, etc., and achieve good industrialization and practical prospects, simple equipment, and improved surface biological properties. Effect

Inactive Publication Date: 2012-10-03
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the existing technologies have their own shortcomings. For example, the chemical reagent method takes a long time, the plasma technology requires complex equipment, and it is difficult to achieve grafting on the inner surface of the material by ultraviolet irradiation. High-energy radiation may affect the properties of the material itself.

Method used

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  • Polyurethane material surface-modified by polyethylene glycol and derivatives thereof as well as preparation method and application thereof
  • Polyurethane material surface-modified by polyethylene glycol and derivatives thereof as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Dissolve 0.50 g of diphenylmethane diisocyanate (MDI) in 10 mL of a mixed solvent of o-dichlorobenzene (DCB) and toluene (Tol) in a volume ratio of 4:6 to obtain solution A.

[0037] (2) Set the area to 20cm 2Immerse the polyurethane material in 10mL solution A, add catalyst triethylamine (TEA) 0.25g, place in microwave field, under 100W microwave irradiation power, react 10min, take out, wash, dry, obtain PU-NCO product (namely PU-MDI), the -NCO content per unit area measured by the acetone-di-n-butylamine titration method is 125 × 10 -8 mol cm -2 (Xiong Jun, Sun Fang, Du Hongguang. Determination of isocyanate groups in polyurethane by acetone-di-n-butylamine titration. Analytical Laboratory, 2007, 26 (8): 73-76), its surface total reflection infrared spectrum is shown in the appendix figure 1 Spectrum b and spectrum a are polyurethane materials. Compared with the spectrum of polyurethane material (spectrum a), the 2287cm of spectrum b -1 The stretching vibrati...

Embodiment 2

[0041] (1) Dissolve 1.00 g of hexamethylene diisocyanate (HDI) in 20 mL of a mixed solvent of o-dichlorobenzene (DCB) and toluene (Tol) in a volume ratio of 8:2 to obtain solution A.

[0042] (2) Set the area to 40cm 2 The polyurethane material is immersed in 20mL solution A, and 0.20g of catalyst stannous octoate is added. Place in a microwave field, and react for 5 minutes under 75W microwave irradiation power. Take out, wash, dry, obtain PU-NCO product, the -NCO content of its unit area is 50 * 10 -8 mol cm -2 .

[0043] (3) Add 0.50g (1.25×10 -3 mol) polyethylene glycol (PEG400) with a relative molecular mass of 400 was dissolved in 20 mL of a mixed solvent of o-dichlorobenzene (DCB) and toluene (Tol) at a volume ratio of 6:4 to obtain solution B.

[0044] (4) the area prepared by step (2) is 40cm 2 The PU-NCO product was immersed in 20mL of solution B, and 0.05g of the catalyst stannous octoate and 0.10g of triethylenediamine (TEDA) were added. Place in a microwave...

Embodiment 3

[0046] (1) Add 0.50g (2.5×10 -4 mol) monomethoxypolyethylene glycol (mPEG2000) with a relative molecular mass of 2000 was dissolved in 10 mL of a mixed solvent of o-dichlorobenzene (DCB) and toluene (Tol) at a volume ratio of 1:9 to obtain solution B.

[0047] (2) the area prepared by embodiment 1 step (2) is 20cm 2 The PU-NCO product was immersed in 10 mL of solution B, and 0.10 g of catalyst stannous octoate and 0.05 g of triethylenediamine (TEDA) were added. Place in a microwave field, and react for 10 minutes under 100W microwave irradiation power. Take out, wash and dry to obtain PU-MDI-mPEG2000 product. Adopt the acetone-di-n-butylamine titration method to measure the change of -NCO content after the reaction, draw the mPEG2000 graft content of its unit area to be 107 * 10 -8 mol cm -2 , the grafting rate reaches 86%. Through in vitro testing, the amount of fibrinogen adsorption of mPEG2000-modified PU is 85% lower than that of unmodified PU as measured by the micro...

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Abstract

The invention discloses a polyurethane material surface-modified by polyethylene glycol and derivatives thereof as well as a preparation method and application thereof. The preparation method of the surface-modified polyurethane material comprises the steps of: at first, dissolving isocyanate in a solvent prepared from orthodichlorobenzene and methylbenzene to obtain a solution A; dissolving polyethylene glycol or derivatives of the polyethylene glycol in the solvent prepared from the orthodichlorobenzene and the methylbenzene to obtain a solution B; immersing a polyurethane material in the solution A, performing microwave radiation reaction to obtain a treated polyurethane material, then immersing the treated polyurethane material in the solution B, and performing microwave radiation reaction again to obtain the polyurethane material surface-modified by the polyethylene glycol and the derivatives thereof. By using the method, the reaction time is remarkably shortened, the energy consumption for production is reduced and the production cost is saved, the used equipment is simple, technologies are mature, and the method has a favorable industrial practical prospect; and the obtained surface-modified polyurethane material further improves the biological performance of the surface of materials, and can be widely applied to the fields, such as implantable devices, medical devices contacting with blood, and the like.

Description

technical field [0001] The invention belongs to the technical field of surface modification of polymer materials, and in particular relates to a surface-modified polyurethane material of polyethylene glycol or its derivatives and its preparation and application. Background technique [0002] The full name of polyurethane (PU) is polyurethane. It is a polymer containing repeated carbamate groups (-NHCOO-) on the main chain of the polymer. It is a soft polymer composed of polyols (polyether, polyester, etc.). Segment and hard segment composed of isocyanate and small molecule chain extender (diamine or diol) are formed by polymerization. By adjusting the soft segment or hard segment structure, length, distribution and relative proportion of polyurethane, the properties of polyurethane can be regulated. Since polyurethane materials can have good comprehensive properties such as mechanical strength, elasticity, wear resistance, flexural resistance, solvent resistance, hydrolysis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G18/78C08G18/48C08G18/83A61L33/06A61L31/06
Inventor 曾戎屠美赵剑豪麦伟忠
Owner JINAN UNIVERSITY
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