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Flusilazole water dispersible granule and its preparation process

A technology of flusilazole and dispersible granules, which is applied in the direction of biocide, bactericide, biocide, etc., can solve the problems of lack of theoretical and experimental basis, simple configuration process, and vague configuration ratio, and achieve convenient and safe storage and transportation. Small size, the effect of reducing the impact on the environment

Active Publication Date: 2015-07-29
南通南沈植保科技开发有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application patent number is 200610013029.9, which discloses a fungicidal composition of flusilazole and kresoxim-methyl, which can be formulated into various dosage forms. Fuzzy, lacking theoretical and experimental basis, failing to achieve the intended efficacy of the two drugs, and even bringing unforeseen side effects

Method used

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  • Flusilazole water dispersible granule and its preparation process
  • Flusilazole water dispersible granule and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Select 5 grams of flusilazole technical material, 2 grams of xylene solvent, and 5 grams of alkylnaphthalene sulfonic acid condensation polymer sodium salt surfactant to mix, dissolve into a uniform organic liquid phase in a water bath at 55 ° C, and use 30 grams of The activated alumina adsorbent is adsorbed into a solid wet material; then 6 grams of T2020 dispersant, 3 grams of TERWET1004 wetting agent, and 34 grams of kaolin filler are mixed, and crushed into a solid dry material by airflow; the solid wet material and the solid dry material are kneaded For processing, adding appropriate amount of water as a binder; finally performing extrusion granulation, drying, and sieving to obtain flusilazole water-dispersible granules with a particle size of 500 μm to 5 mm and an active ingredient of about 6%. The experimental results show that the physical suspension rate of the sample is 81%, and the chemical suspension rate is 92%.

Embodiment 2

[0027] Example 2: 25 grams of the original drug of flusilazole, 3 grams of No. 200 heavy aromatic hydrocarbon solvent, and 5 grams of enhanced naphthalenesulfonate surfactants were mixed, dissolved in a water bath at 60°C to form a uniform organic liquid phase, and 30 grams of corn Adsorb starch into a solid wet material; then mix 7 grams of YUS-WG4 dispersant, 2 grams of YUS-SXC wetting agent and 18 grams of diatomaceous earth filler, and crush it into a solid dry material through airflow; mix the solid wet material and solid dry material Carry out kneading treatment, add an appropriate amount of water as a binder; finally carry out extrusion granulation, drying and sieving to obtain flusilazole water-dispersible granules with a particle size of 500 μm to 5 mm and an active ingredient of about 28%. The experimental results show that the physical suspension rate of the sample is 83%, and the chemical suspension rate is 95%.

Embodiment 3

[0028] Example 3: 40 grams of flusilazole original drug, 3 grams of No. 150 heavy aromatic hydrocarbon solvent, and 5 grams of non-ionic block copolymer surfactant are mixed, dissolved in a water bath at 70°C to form a uniform organic liquid phase, and 8 grams of corn Starch and 20 grams of white carbon black adsorbent are adsorbed into a solid wet material; then 5 grams of D425 dispersant, 4 grams of SD200 wetting agent and 15 grams of attapulgite filler are mixed, and crushed into a solid dry material by airflow; the solid wet material Knead with solid dry material, add appropriate amount of water as binder; finally carry out extrusion granulation, drying, and sieving to obtain a water dispersion of flusilazole with a particle size of 500 μm to 5 mm and an active ingredient of about 40%. granules. The experimental results show that the physical suspension rate of the sample is 80%, and the chemical suspension rate is 91%.

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Abstract

The invention provides a flusilazole water dispersible granule which contains 5% to 40% of flusilazole, 0% to 5% of solvent, 5% to 20% of surface active agent, 10% to 20% of absorbant, inert fillers and the like. A preparation process of the flusilazole water dispersible granule comprises the steps of: dissolving crude drugs of flusilazole by using the solvent and the surface active agent under heating and stirring conditions to form a uniform organic liquid phase; then, absorbing the organic liquid phase into a solid wet material by using the absorbant; mixing solid dry materials such as inert fillers and the like into the solid wet material; and after pinching in a pinching machine, extruding, granulating, drying and sieving to obtain the water dispersible granule. The water dispersible granule has high content of effective components and better water dispersity and suspension, is capable of sufficiently playing the medical effect of the flusilazole, is safe and convenient in storage, transportation, measurement and utilization and meets the development requirement of an environmental friendly insecticide.

Description

technical field [0001] The invention relates to a flusilazole bactericide in agricultural chemicals, in particular to a water-dispersible granule whose main active ingredient is flusilazole and a preparation process thereof. Background technique [0002] Fluorosilazole, molecular formula: C16H15F2N3Si, chemical name: bis(4-fluorophenyl)-(1H-1,2,4-triazol-1-ylmethyl)silane, chemical structural formula: [0003] [0004] Flusilazole can be used as an agricultural fungicide; at present, the dosage forms of flusilazole fungicide are mainly emulsifiable concentrate (57%), water emulsion (16%) and microemulsion (18%), because these dosage forms contain a large amount of organic solvents , the active ingredient is low, which will have a negative impact on the environment; there is also a small part of the dosage form is powder, which pollutes the air with dust when used, and the crops are poorly absorbed, and the efficacy of the medicine is reduced. [0005] A fluorosilazole-co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N55/10A01N25/14A01P3/00
Inventor 许鑫戴宝江杭建胜吴明
Owner 南通南沈植保科技开发有限公司